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公开(公告)号：US4871771A
公开(公告)日：1989-10-03
申请号：US152191
申请日：1988-02-04
IPC分类号： A61K31/19 , A61P9/00 , A61P13/02 , A61P15/00 , A61P25/04 , A61P29/00 , A61P37/08 , A61P43/00 , C07C323/56
CPC分类号： A61K31/19
摘要： A method for inhibiting the effects of LTB.sub.4 comprises administration of an effective amount of a compound represented by the following structural formula (I) ##STR1## wherein m is 1 or 2; n is 1, 2 or 3; p is 0, 1, or 2; R' is hydrogen or methyl; R is phenyl substituted with A, R.sub.1 and R.sub.2 wherein R.sub.1 and R.sub.2 are independently selected from either (1) (S).sub.a --(CH.sub.2).sub.b --(T).sub.c --B wherein a is 0 or 1; b is 5 to 12; c is 0 or 1; S and T are independently sulfur, oxygen, or CH.sub.2 with the proviso that S or T are not sulfur when p is 1 or 2; and B is C.sub.1-4 alkyl, ethynyl, trifluoromethyl, or phenyl optionally monosubstituted with Br, Cl, CF.sub.3, C.sub.1-4 alkoxy, C.sub.1-4 alkyl, methylthio, or trifluoromethylthio; or (2) hydrogen bromo, chloro, methyl, trifluoromethyl, methoxy or nitro; and A is selected from (2) as defined above or a pharmaceutically acceptable salt thereof. Such methods are useful in the treatment of diseases in which LTB.sub.4 is a factor.
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公开(公告)号：US4387239A
公开(公告)日：1983-06-07
申请号：US333850
申请日：1981-12-22
IPC分类号： C07C17/16 , C07C29/17 , C07C29/32 , C07C33/02 , C07C33/04 , C07D303/40 , C07D303/42 , C07F9/54
CPC分类号： C07F9/5428 , C07C17/16 , C07C29/17 , C07C29/32 , C07C33/02 , C07C33/04 , C07D303/40 , C07D303/42 , C07B2200/09
摘要： Esters of leukotriene A are conveniently prepared by reacting 9-oxo-5,6-trans-epoxynon-7(E)-enoates with 11-triphenylphosphoranylidene undec-6(Z),9(Z)-diene. Esters of leukotriene-A are useful intermediates in the synthesis of naturally occurring leukotrienes, which have been shown to be potent broncho-constricting substances. Novel intermediates to the esters of leukotriene A. 9-oxo-5,6-trans-epoxynon-7(E)-enoates and 7-oxo-5,6-trans-epoxyheptanoates, are disclosed.
摘要翻译： 通过9-氧代-5,6-反式环氧壬基-7（E） - 烯酸酯与11-三苯基亚正膦基十一碳烯-6（Z），9（Z） - 二烯反应，方便地制备白三烯A的酯。 白三烯-A的酯类是天然存在的白三烯合成中的有用中间体，已被证明是有效的支气管收缩物质。 公开了白三烯A 9-氧代-5,6-反式环氧壬烷-7（E） - 烯酸酯和7-氧代-5,6-反式 - 环氧庚酸酯的新型中间体。
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公开(公告)号：US4440939A
公开(公告)日：1984-04-03
申请号：US439088
申请日：1982-11-04
IPC分类号： C07C17/16 , C07C29/17 , C07C29/32 , C07C33/02 , C07C33/04 , C07D303/40 , C07D303/42 , C07F9/54
CPC分类号： C07F9/5428 , C07C17/16 , C07C29/17 , C07C29/32 , C07C33/02 , C07C33/04 , C07D303/40 , C07D303/42 , C07B2200/09
摘要： Esters of leukotriene A are conveniently prepared by reacting 9-oxo-5,6-trans-epoxynon-7(E)-enoates with 11-triphenylphosphoranylidene undec-6(Z),9(Z)-diene. Esters of leukotriene-A are useful intermediates in the synthesis of naturally occurring leukotrienes, which have been shown to be potent broncho-constricting substances. Novel intermediates to the esters of leukotriene A, 9-oxo-5,6-transepoxynon-7(E)-enoates and 7-oxo-5,6-trans-epoxyheptanoates, are disclosed.
摘要翻译： 通过9-氧代-5,6-反式环氧壬基-7（E） - 烯酸酯与11-三苯基亚正膦基十一碳烯-6（Z），9（Z） - 二烯反应，方便地制备白三烯A的酯。 白三烯-A的酯类是天然存在的白三烯合成中的有用中间体，已被证明是有效的支气管收缩物质。 公开了白三烯A，9-氧代-5,6-过氧壬烯-7（E） - 烯酸酯和7-氧代-5,6-反式 - 环氧庚酸酯的新型中间体。
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公开(公告)号：US4352757A
公开(公告)日：1982-10-05
申请号：US230915
申请日：1981-02-02
IPC分类号： C07C17/16 , C07C29/17 , C07C29/32 , C07C33/02 , C07C33/04 , C07D303/40 , C07D303/42 , C07F9/54
CPC分类号： C07F9/5428 , C07C17/16 , C07C29/17 , C07C29/32 , C07C33/02 , C07C33/04 , C07D303/40 , C07D303/42
摘要： Esters of leukotriene A are conveniently prepared by reacting 9-oxo-5,6-trans-epoxynon-7(E)-enoates with 11-triphenylphosphoranylidene undec-6(Z),9(Z)-diene. Esters of leukotriene-A are useful intermediates in the synthesis of naturally occurring leukotrienes, which have been shown to be potent broncho-constricting substances. Novel intermediates to the esters of leukotriene A, 9-oxo-5,6-transepoxynon-7(E)-enoates and 7-oxo-5,6-transepoxyheptanoates, are disclosed.
摘要翻译： 通过9-氧代-5,6-反式环氧壬基-7（E） - 烯酸酯与11-三苯基亚正膦基十一碳烯-6（Z），9（Z） - 二烯反应，方便地制备白三烯A的酯。 白三烯-A的酯类是天然存在的白三烯合成中的有用中间体，已被证明是有效的支气管收缩物质。 公开了白三烯A，9-氧代-5,6-脱氧壬基-7（E） - 烯酸酯和7-氧代-5,6-异丙氧基庚酸酯的新型中间体。
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