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    Quinolines and Their Therapeutic Use
    1.
    发明申请
    Quinolines and Their Therapeutic Use 有权
    喹啉及其治疗用途

    公开(公告)号：US20100144787A1

    公开(公告)日：2010-06-10

    申请号：US12531935

    申请日：2008-04-03

    申请人： John Gary Montana ,  Harry Finch ,  George Hynd ,  Michael Colin Cramp ,  Rosa Arienzo ,  Neville McLean

    发明人： John Gary Montana ,  Harry Finch ,  George Hynd ,  Michael Colin Cramp ,  Rosa Arienzo ,  Neville McLean

    IPC分类号： A61K31/4709 ,  C07D215/233 ,  C07D215/227 ,  C07D215/12 ,  A61P11/06 ,  A61P11/08 ,  A61P11/16 ,  A61P11/02

    CPC分类号： C07D401/10 ,  C07D215/227 ,  C07D215/233 ,  C07D413/10 ,  C07D417/10

    摘要： Compounds of formula (I) are CRTH2 ligands, useful in the treatment of, for example, asthma and COPD wherein: R1 is halogen or cyano; R2 is hydrogen or methyl; R3 and R4 are independently —OR6, C1-C6alkyl or C3-C6cycloalkyl, the latter two groups being optionally substituted by one or more halogen atoms; R5 is hydrogen or halogen; R6 is C1C6 alkyl or C3-C6 cycloalkyl, either of which being optionally substituted by one or more halogen atoms; X is —CH2—, —S—, or —O—; one of Y and Y1 is hydrogen and the other is OR6, —C(═O)R7, NR8SO2R6 or a heterocyclic group selected from those referred to in the specification; and R6, R7 and R8 are as defined in the specification.

    摘要翻译： 式（I）化合物是可用于治疗例如哮喘和COPD的CRTH2配体，其中：R1是卤素或氰基; R2是氢或甲基; R 3和R 4独立地为-OR 6，C 1 -C 6烷基或C 3 -C 6环烷基，后两个基团任选被一个或多个卤素原子取代; R5是氢或卤素; R6是C1C6烷基或C3-C6环烷基，其任一个任选被一个或多个卤素原子取代; X是-CH 2 - ， - S-或-O-; Y和Y1中的一个是氢，另一个是选自本说明书中提到的那些的OR 6，-C（= O）R 7，NR 8 SO 2 R 6或杂环基; R6，R7和R8如说明书中所定义。

    Quinolines and their therapeutic use
    2.
    发明授权
    Quinolines and their therapeutic use 有权
    喹啉及其治疗用途

    公开(公告)号：US08173812B2

    公开(公告)日：2012-05-08

    申请号：US12531935

    申请日：2008-04-03

    申请人： John Gary Montana ,  Harry Finch ,  George Hynd ,  Michael Colin Cramp ,  Rosa Arienzo ,  Neville McLean

    发明人： John Gary Montana ,  Harry Finch ,  George Hynd ,  Michael Colin Cramp ,  Rosa Arienzo ,  Neville McLean

    IPC分类号： C07D215/38 ,  A61K31/04

    CPC分类号： C07D401/10 ,  C07D215/227 ,  C07D215/233 ,  C07D413/10 ,  C07D417/10

    摘要： Compounds of formula (I) are CRTH2 ligands, useful in the treatment of, for example, asthma and COPD wherein: R1 is halogen or cyano; R2 is hydrogen or methyl; R3 and R4 are independently —OR6, C1-C6alkyl or C3-C6cycloalkyl, the latter two groups being optionally substituted by one or more halogen atoms; R5 is hydrogen or halogen; R6 is C1-C6 alkyl or C3-C6 cycloalkyl, either of which being optionally substituted by one or more halogen atoms; X is —CH2—, —S—, or —O—; one of Y and Y1 is hydrogen and the other is OR6, —C(═O)R7, NR8SO2R6 or a heterocyclic group selected from those referred to in the specification; and R6, R7 and R8 are as defined in the specification.

    摘要翻译： 式（I）化合物是可用于治疗例如哮喘和COPD的CRTH2配体，其中：R1是卤素或氰基; R2是氢或甲基; R 3和R 4独立地为-OR 6，C 1 -C 6烷基或C 3 -C 6环烷基，后两个基团任选被一个或多个卤素原子取代; R5是氢或卤素; R6是C1-C6烷基或C3-C6环烷基，其任一个任选被一个或多个卤素原子取代; X是-CH 2 - ， - S-或-O-; Y和Y1中的一个是氢，另一个是选自本说明书中提到的那些的OR 6，-C（= O）R 7，NR 8 SO 2 R 6或杂环基; R6，R7和R8如说明书中所定义。

    Quinolines and their therapeutic use
    4.
    发明授权
    Quinolines and their therapeutic use 有权
    喹啉及其治疗用途

    公开(公告)号：US08394830B2

    公开(公告)日：2013-03-12

    申请号：US13435242

    申请日：2012-03-30

    申请人： John Gary Montana ,  Harry Finch ,  George Hynd ,  Michael Colin Cramp ,  Rosa Arienzo ,  Neville McLean

    发明人： John Gary Montana ,  Harry Finch ,  George Hynd ,  Michael Colin Cramp ,  Rosa Arienzo ,  Neville McLean

    IPC分类号： A61K31/04

    CPC分类号： C07D401/10 ,  C07D215/227 ,  C07D215/233 ,  C07D413/10 ,  C07D417/10

    摘要： Compounds of formula (I) are CRTH2 ligands, useful in the treatment of, for example, asthma and COPD wherein: R1 is halogen or cyano; R2 is hydrogen or methyl; R3 and R4 are independently —OR6, C1-C6alkyl or C3-C6cycloalkyl, the latter two groups being optionally substituted by one or more halogen atoms; R5 is hydrogen or halogen; R6 is C1C6alkyl or C3-C6cycloalkyl, either of which being optionally substituted by one or more halogen atoms; X is —CH2—, —S—, or —O—; one of Y and Y1 is hydrogen and the other is OR6, —C(═O)R7, NR8SO2R6 or a heterocyclic group selected from those referred to in the specification; and R6, R7 and R8 are as defined in the specification.

    摘要翻译： 式（I）化合物是可用于治疗例如哮喘和COPD的CRTH2配体，其中：R1是卤素或氰基; R2是氢或甲基; R 3和R 4独立地为-OR 6，C 1 -C 6烷基或C 3 -C 6环烷基，后两个基团任选被一个或多个卤素原子取代; R5是氢或卤素; R6是C1C6烷基或C3-C6环烷基，其中任一个任选被一个或多个卤素原子取代; X是-CH 2 - ， - S-或-O-; Y和Y1中的一个是氢，另一个是选自本说明书中提到的那些的OR 6，-C（= O）R 7，NR 8 SO 2 R 6或杂环基; R6，R7和R8如说明书中所定义。