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公开(公告)号：US20090274702A1
公开(公告)日：2009-11-05
申请号：US12499817
申请日：2009-07-09
申请人： John Hamilton , Ian Keith Campbell
发明人： John Hamilton , Ian Keith Campbell
IPC分类号： A61K39/395 , C07K16/18 , A61P3/10
CPC分类号： A61K31/00 , A61K2039/505 , C07K16/241 , C07K16/243 , C07K2317/73 , G01N33/5047
摘要： The present invention relates generally to a method for the treatment and prophylaxis of inflammatory conditions. The present invention is predicated in part on the identification of cells of the monocyte/macrophage lineage being critical for inflammation and, in particular, chronic inflammation. In accordance with the present invention, it is proposed that the reduction in levels of monocyte/macrophage-type cells and/or a reduction in the production of inflammatory and pro-inflammatory mediators by these cells, especially locally, is effective in reducing inflammatory conditions. The present invention further provides animal models useful for screening for reducing levels of monocyte/macrophage-type cells and/or reducing the production of inflammatory and pro-inflammatory mediators of these cells.
摘要翻译： 本发明一般涉及治疗和预防炎性病症的方法。 本发明部分地基于对炎症，特别是慢性炎症至关重要的单核细胞/巨噬细胞谱系的细胞的鉴定。 根据本发明，提出单核细胞/巨噬细胞型细胞水平的降低和/或由这些细胞，特别是局部的炎症和促炎介质的产生减少在减少炎性病症中是有效的 。 本发明进一步提供可用于筛选单核细胞/巨噬细胞型细胞水平降低和/或减少这些细胞的炎症和促炎介质的产生的动物模型。
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公开(公告)号：US08062637B2
公开(公告)日：2011-11-22
申请号：US12499817
申请日：2009-07-09
申请人： John Hamilton , Ian Keith Campbell
发明人： John Hamilton , Ian Keith Campbell
CPC分类号： A61K31/00 , A61K2039/505 , C07K16/241 , C07K16/243 , C07K2317/73 , G01N33/5047
摘要： The present invention relates generally to a method for the treatment and prophylaxis of inflammatory conditions. The present invention is predicated in part on the identification of cells of the monocyte/macrophage lineage being critical for inflammation and, in particular, chronic inflammation. In accordance with the present invention, it is proposed that the reduction in levels of monocyte/macrophage-type cells and/or a reduction in the production of inflammatory and pro-inflammatory mediators by these cells, especially locally, is effective in reducing inflammatory conditions. The present invention further provides animal models useful for screening for reducing levels of monocyte/macrophage-type cells and/or reducing the production of inflammatory and pro-inflammatory mediators of these cells.
摘要翻译： 本发明一般涉及治疗和预防炎性病症的方法。 本发明部分地基于对炎症，特别是慢性炎症至关重要的单核细胞/巨噬细胞谱系的细胞的鉴定。 根据本发明，提出单核细胞/巨噬细胞型细胞水平的降低和/或由这些细胞，特别是局部的炎症和促炎介质的产生减少在减少炎性病症中是有效的 。 本发明进一步提供可用于筛选单核细胞/巨噬细胞型细胞水平降低和/或减少这些细胞的炎症和促炎介质的产生的动物模型。
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公开(公告)号：US20120177654A1
公开(公告)日：2012-07-12
申请号：US13335974
申请日：2011-12-23
IPC分类号： A61K39/395 , A61P19/00 , A61P11/00 , A61P25/00 , A61P17/06 , A61P1/00 , A61K38/02 , A61P3/04
CPC分类号： C07K16/2866 , A61K38/1793 , A61K39/3955 , A61K2039/505 , A61P29/00 , C07K16/241 , C07K16/243 , C07K2317/73 , C07K2317/76 , G01N33/5047
摘要： The present invention relates generally to a method for the treatment and prophylaxis of inflammatory conditions. The present invention is predicated in part on the identification of cells of the monocyte/macrophage lineage being critical for inflammation and, in particular, chronic inflammation. In accordance with the present invention, it is proposed that the reduction in levels of monocyte/macrophage-type cells and/or a reduction in the production of inflammatory and pro-inflammatory mediators by these cells, especially locally, is effective in reducing inflammatory conditions. The present invention further provides animal models useful for screening for reducing levels of monocyte/macrophage-type cells and/or reducing the production of inflammatory and pro-inflammatory mediators of these cells.
摘要翻译： 本发明一般涉及治疗和预防炎性病症的方法。 本发明部分地基于对炎症，特别是慢性炎症至关重要的单核细胞/巨噬细胞谱系的细胞的鉴定。 根据本发明，提出单核细胞/巨噬细胞型细胞水平的降低和/或由这些细胞，特别是局部的炎症和促炎介质的产生减少在减少炎性病症中是有效的 。 本发明进一步提供可用于筛选单核细胞/巨噬细胞型细胞水平降低和/或减少这些细胞的炎症和促炎介质的产生的动物模型。
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公开(公告)号：US08142777B2
公开(公告)日：2012-03-27
申请号：US11856949
申请日：2007-09-18
申请人： John Hamilton , Ian Keith Campbell
发明人： John Hamilton , Ian Keith Campbell
IPC分类号： A61K39/395 , A61K39/00
CPC分类号： C07K16/2866 , A61K31/00 , A61K38/1793 , A61K39/3955 , A61K2039/505 , C07K16/241 , C07K16/243 , C07K2317/73 , C07K2317/76 , G01N33/5047
摘要： The present invention relates generally to a method for the treatment and prophylaxis of inflammatory conditions. The present invention is predicated in part on the identification of cells of the monocyte/macrophage lineage being critical for inflammation and, in particular, chronic inflammation. In accordance with the present invention, it is proposed that the reduction in levels of monocyte/macrophage-type cells and/or a reduction in the production of inflammatory and pro-inflammatory mediators by these cells, especially locally, is effective in reducing inflammatory conditions. The present invention further provides animal models useful for screening for reducing levels of monocyte/macrophage-type cells and/or reducing the production of inflammatory and pro-inflammatory mediators of these cells.
摘要翻译： 本发明一般涉及治疗和预防炎性病症的方法。 本发明部分地基于对炎症，特别是慢性炎症至关重要的单核细胞/巨噬细胞谱系的细胞的鉴定。 根据本发明，提出单核细胞/巨噬细胞型细胞水平的降低和/或由这些细胞，特别是局部的炎症和促炎介质的产生减少在减少炎性病症中是有效的 。 本发明进一步提供可用于筛选单核细胞/巨噬细胞型细胞水平降低和/或减少这些细胞的炎症和促炎介质的产生的动物模型。
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公开(公告)号：US07455836B2
公开(公告)日：2008-11-25
申请号：US09851230
申请日：2001-05-08
CPC分类号： C07K16/2866 , A61K31/00 , A61K38/1793 , A61K39/3955 , A61K2039/505 , C07K16/241 , C07K16/243 , C07K2317/73 , C07K2317/76 , G01N33/5047
摘要： The present invention relates generally to a method for the treatment and prophylaxis of inflammatory conditions. The present invention is predicated in part on the identification of cells of the monocyte/macrophage lineage being critical for inflammation and, in particular, chronic inflammation. In accordance with the present invention, it is proposed that the reduction in levels of monocyte/macrophage-type cells and/or a reduction in the production of inflammatory and pro-inflammatory mediators by these cells, especially locally, is effective in reducing inflammatory conditions. The present invention further provides animal models useful for screening for reducing levels of monocyte/macrophage-type cells and/or reducing the production of inflammatory and pro-inflammatory mediators of these cells.
摘要翻译： 本发明一般涉及治疗和预防炎性病症的方法。 本发明部分地基于对炎症，特别是慢性炎症至关重要的单核细胞/巨噬细胞谱系的细胞的鉴定。 根据本发明，提出单核细胞/巨噬细胞型细胞水平的降低和/或由这些细胞，特别是局部的炎症和促炎介质的产生减少在减少炎性病症中是有效的 。 本发明进一步提供可用于筛选单核细胞/巨噬细胞型细胞水平降低和/或减少这些细胞的炎症和促炎介质的产生的动物模型。
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公开(公告)号：USD686003S1
公开(公告)日：2013-07-16
申请号：US29390353
申请日：2011-04-22
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公开(公告)号：USD677911S1
公开(公告)日：2013-03-19
申请号：US29390337
申请日：2011-04-22
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公开(公告)号：US20080295745A1
公开(公告)日：2008-12-04
申请号：US12128791
申请日：2008-05-29
申请人： John Hamilton , Kurt Heidman , Steven James Beukema , Jay Grandin
发明人： John Hamilton , Kurt Heidman , Steven James Beukema , Jay Grandin
CPC分类号： A47B13/06 , A47B2200/0013
摘要： A table has two end legs arranged in a parallel, laterally spaced apart relationship for support on a floor surface. Two side rails are arranged in a parallel, laterally spaced apart relationship, and are connected with upper portions of the end legs to retain them in an upright orientation, defining a self-supported table frame without intermediate bracing between the side rails, with a central, vertically extending widow. Top support members are connected with the side rails and protrude outwardly therefrom in a cantilevered fashion. A top member is supported on and connected with the table frame and the top support members, defining a plurality of workstations. A utility module configured to route utilities is positioned within the window of the frame, with opposite sides abuttingly supported on the side rails to removably mount the utility module on the frame and thereby accommodate different utility requirements at the workstations.
摘要翻译： 桌子具有以平行的横向间隔开的关系布置的两个端部腿，用于支撑在地板表面上。 两个侧轨布置成平行的横向间隔开的关系，并且与端腿的上部连接以将它们保持在直立的方向，从而限定了一个自支撑的桌面框架，而在侧轨之间没有中间支撑， ，垂直延伸的寡妇。 顶部支撑构件与侧轨连接并以悬臂方式向外突出。 顶部构件支撑并与桌子框架和顶部支撑构件连接，定义了多个工作站。 配置为路由公用事业的实用程序模块位于框架的窗口内，相对的侧面邻接支撑在侧轨上，以将可用模块可拆卸地安装在框架上，从而适应工作站的不同的实用要求。
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公开(公告)号：US20080016804A1
公开(公告)日：2008-01-24
申请号：US11696388
申请日：2007-04-04
申请人： James Ludwig , John Hamilton , Daniel Van Alphen
发明人： James Ludwig , John Hamilton , Daniel Van Alphen
IPC分类号： E04G11/04
CPC分类号： E04B2/7416 , A47C11/00 , A47C13/005 , E04B2002/7418 , E04B2002/7483
摘要： A system for dividing a workspace includes a wall designed to divide the workspace into a workspace and an area outside of the workspace. The wall includes a variety of features such as a seat back located in the workspace and positioned proximate to and spaced from the wall and configured to form a space between the seat back and the wall to accommodate an accessory device.
摘要翻译： 用于分割工作空间的系统包括设计成将工作区划分为工作空间和工作区外的区域的墙壁。 墙壁包括各种特征，例如位于工作空间中的座椅靠背并且被定位成靠近并与壁间隔开并且被配置成在座椅靠背和壁之间形成适应附件装置的空间。
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公开(公告)号：US20070251428A1
公开(公告)日：2007-11-01
申请号：US11412969
申请日：2006-04-27
申请人： Karl Mead , John Hamilton , James Ludwig
发明人： Karl Mead , John Hamilton , James Ludwig
IPC分类号： A47B37/00
CPC分类号： A47B83/001 , A47B13/02 , E04B2/7422 , E04B2002/7483 , E04B2002/7488
摘要： A table for offices and the like includes an elongate center beam and two center posts having lower ends abuttingly supported on a floor surface and upper ends connected with opposite ends of the center beam. Two outrigger beams are positioned on opposite sides of the center beam in a generally mutually perpendicular relationship therewith, and have inner ends connected with one of the center posts. Two outrigger posts are positioned on opposite sides of the center beam, and have lower ends thereof abutting the floor surface and upper ends connected with the outside ends of the outrigger beams to stabilize the table. Two elongate worksurfaces are positioned along opposite sides of the center beam and have a length generally commensurate with the same. The worksurfaces have inside edges connected with and at least partially supported by the center beam, end segments abutting and at least partially supported by the upper ends of the outrigger posts, and outside edges which protrude outwardly from the outrigger posts in a cantilevered fashion and extend freely therealong to permit unencumbered access to the worksurfaces.
摘要翻译： 用于办公室等的桌子包括细长的中心束和两个中心柱，其中下端部邻接地支撑在地板表面上，并且上端部与中心梁的相对端连接。 两个支腿梁以与其大致相互垂直的关系定位在中心梁的相对侧上，并且内端与一个中心柱连接。 两个外伸支架位于中心梁的相对侧上，并且其下端邻接地板表面，并且上端与外伸支架梁的外端相连以稳定工作台。 两个细长工件表面沿着中心梁的相对侧定位，并且具有与其相同的长度。 工件表面具有与中心梁连接并且至少部分地由中心梁支撑的内边缘，端部段邻接并且至少部分地由外伸支架柱的上端部支撑，以及从悬臂支柱向外以悬臂方式向外突出的外边缘，并且延伸 自由地允许不受阻碍地访问工作表面。
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