公开(公告)号：US20070299120A1

公开(公告)日：2007-12-27

申请号：US11765359

申请日：2007-06-19

申请人： John Janusz ,  Stephen Hodson ,  Gregory Bosch ,  Ronald White ,  Benjamin Blass ,  Christopher Jackson ,  Neil Fairweather

发明人： John Janusz ,  Stephen Hodson ,  Gregory Bosch ,  Ronald White ,  Benjamin Blass ,  Christopher Jackson ,  Neil Fairweather

IPC分类号： A61K31/4166 ,  A61P9/06 ,  C07D233/32

CPC分类号： C07D233/38

摘要： The present invention relates to 1-N-amino-2-imidazolidinones and derivatives thereof which are effective as Kv1.5 potassium channel inhibitors providing atrial-selective antiarrhythmic agents. The present invention further relates to compositions comprising said Kv1.5 potassium channel inhibitors, and to methods for treating cardiac arrhythmia.

摘要翻译： 本发明涉及作为提供心房选择性抗心律失常药物的Kv1.5钾通道抑制剂有效的1-N-氨基-2-咪唑啉酮及其衍生物。 本发明还涉及包含所述Kv1.5钾通道抑制剂的组合物，以及用于治疗心律失常的方法。

公开(公告)号：US20070299072A1

公开(公告)日：2007-12-27

申请号：US11765357

申请日：2007-06-19

申请人： John Janusz ,  Shengde Wu ,  Neil Fairweather ,  Wenlin Lee ,  Benjamin Blass ,  Andrew Fluxe ,  Stephen Hodson ,  James Ridgeway

发明人： John Janusz ,  Shengde Wu ,  Neil Fairweather ,  Wenlin Lee ,  Benjamin Blass ,  Andrew Fluxe ,  Stephen Hodson ,  James Ridgeway

IPC分类号： A61K31/438 ,  A61K31/496 ,  A61K31/5377 ,  A61P25/04 ,  C07D241/04 ,  C07D265/30 ,  C07D471/10

CPC分类号： C07D471/10

摘要： The present invention relates to 4-oxo-1,3,8-triaza-spiro[4.5]decanes which are useful as Kv1.5 potassium channel inhibitors providing atrial-selective antiarrhythmic activity. The present invention further relates to compositions and methods for treating atrial-selective antiarrhythmia.

摘要翻译： 本发明涉及可用作提供心房选择性抗心律失常活性的Kv1.5钾通道抑制剂的4-氧代-1,3,8-三氮杂 - 螺[4.5]癸烷。 本发明还涉及用于治疗心房选择性抗心律失常的组合物和方法。

公开(公告)号：US06635692B1

公开(公告)日：2003-10-21

申请号：US09445682

申请日：2001-04-20

申请人： Gregor Bruce Yeo Christie ,  Victor Christov ,  Peter Canisius De Nys ,  Peter Steinberg ,  Stephen Hodson

发明人： Gregor Bruce Yeo Christie ,  Victor Christov ,  Peter Canisius De Nys ,  Peter Steinberg ,  Stephen Hodson

IPC分类号： C08K546

CPC分类号： A01N43/08 ,  A01N25/10 ,  A01N43/80 ,  C08K5/0058 ,  C08L23/02 ,  C08L101/00 ,  A01N2300/00 ,  C08L2666/04

摘要： A range of extruded polymers incorporating synthetic furanones was manufactured and field tested. Polymers incorporating furanones showed excellent antifouling efficacy and significantly reduced fouling for more than 100 days. The present inventors have developed polymers that release commercial short-lived biocides or analogues of antifouling compounds isolated from marine algae. A range of polymers incorporating either the commercial isothiazolone Sea-Nine 211™ or a halogenated furanone were effective antifouling treatments in laboratory and field trials. The efficacy of the polymers was dependant on polymer type and the initial concentration of the antifouling compound. The polymers can be extruded as filaments that can be woven into netting or extruded or molding for other applications. It will be appreciated by persons skilled in the art that numerous variations and/or modifications may be made to the invention as shown in the specific embodiments without departing from the spirit or scope of the invention as broadly described. The present embodiments are, therefore, to be considered in all respects as illustrative and not restrictive.

摘要翻译： 一系列合成呋喃酮的挤出聚合物被制造和现场测试。 结合呋喃酮的聚合物显示出优异的防污效果，并且显着减少了超过100天的结垢。本发明人开发了释放商业短寿命杀生物剂或从海藻分离的防污化合物的类似物的聚合物。 掺入商业异噻唑酮Sea-Nine 211 TM或卤代呋喃酮的一系列聚合物是实验室和现场试验中有效的防污处理。 聚合物的功效取决于聚合物类型和防污化合物的初始浓度。 聚合物可以挤出为可以编织成网或挤出或模制用于其它应用的长丝。本领域技术人员将理解，可以对本发明进行多种变化和/或修改，如具体实施方案中所示 而不脱离如广泛描述的本发明的精神或范围。 因此，本实施例在所有方面都被认为是说明性的而不是限制性的。