公开(公告)号：US20110028487A1

公开(公告)日：2011-02-03

申请号：US12734042

申请日：2009-07-02

申请人： John Joseph Deadman ,  Eric Dale Jones ,  Giang Thanh Le ,  David Ian Rhodes ,  Neeranat Thienthong ,  Nicholas Andrew Van De Graff ,  Lisa Jane Winfield

发明人： John Joseph Deadman ,  Eric Dale Jones ,  Giang Thanh Le ,  David Ian Rhodes ,  Neeranat Thienthong ,  Nicholas Andrew Van De Graff ,  Lisa Jane Winfield

IPC分类号： A61K31/496 ,  C07D487/04 ,  A61K31/519 ,  A61P31/12

CPC分类号： C07D487/04

摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof. The present invention further provides a method of treatment or prophylaxis of a viral infection in a subject comprising administering to said subject an effective amount of a compound of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof. Pharmaceutical compositions comprising a compound of formula (I) are also provided.

摘要翻译： 本发明提供式（I）化合物或其药学上可接受的衍生物，盐或前药。 本发明还提供了治疗或预防受试者病毒感染的方法，其包括向所述受试者施用有效量的式（I）化合物或其药学上可接受的衍生物，盐或前药。 还提供了包含式（I）化合物的药物组合物。

公开(公告)号：US08431581B2

公开(公告)日：2013-04-30

申请号：US12734042

申请日：2009-07-02

申请人： John Joseph Deadman ,  Eric Dale Jones ,  Giang Thanh Le ,  David Ian Rhodes ,  Neeranat Thienthong ,  Nicholas Andrew Van de Graff ,  Lisa Jane Winfield

发明人： John Joseph Deadman ,  Eric Dale Jones ,  Giang Thanh Le ,  David Ian Rhodes ,  Neeranat Thienthong ,  Nicholas Andrew Van de Graff ,  Lisa Jane Winfield

IPC分类号： A01N43/90 ,  A61K31/519 ,  C07D487/00

CPC分类号： C07D487/04

摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof. The present invention further provides a method of treatment or prophylaxis of a viral infection in a subject comprising administering to said subject an effective amount of a compound of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof. Pharmaceutical compositions comprising a compound of formula (I) are also provided.

摘要翻译： 本发明提供式（I）化合物或其药学上可接受的衍生物，盐或前药。 本发明还提供了治疗或预防受试者病毒感染的方法，其包括向所述受试者施用有效量的式（I）化合物或其药学上可接受的衍生物，盐或前药。 还提供了包含式（I）化合物的药物组合物。

公开(公告)号：US08859563B2

公开(公告)日：2014-10-14

申请号：US13405511

申请日：2012-02-27

申请人： Eric Dale Jones ,  Jonathan Alan Victor Coates ,  David Ian Rhodes ,  John Joseph Deadman ,  Nicholas Andrew Van de Graff ,  Lisa Jane Winfield ,  Neeranat Thienthong ,  William Issa ,  Neil Choi ,  Katherine Macfarlane

发明人： Eric Dale Jones ,  Jonathan Alan Victor Coates ,  David Ian Rhodes ,  John Joseph Deadman ,  Nicholas Andrew Van de Graff ,  Lisa Jane Winfield ,  Neeranat Thienthong ,  William Issa ,  Neil Choi ,  Katherine Macfarlane

IPC分类号： A01N43/90 ,  A61K31/519 ,  C07D239/70 ,  C07D487/04 ,  C07D498/04 ,  C07D471/04 ,  C07D513/04

CPC分类号： C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04

摘要： The present invention provides a compound of Formula I or a pharmaceutically acceptable derivative, salt or prodrug thereof. Further provided is a method of treatment or prophylaxis of a viral infection in a subject comprising administering to said subject an effective amount of a compound of Formula I or a pharmaceutically acceptable derivative, salt or prodrug thereof. A pharmaceutical composition or medicament comprising a compound of Formula I is also provided.

摘要翻译： 本发明提供式I化合物或其药学上可接受的衍生物，盐或前药。 还提供了治疗或预防受试者病毒感染的方法，包括向所述受试者施用有效量的式I化合物或其药学上可接受的衍生物，盐或前药。 还提供了包含式I化合物的药物组合物或药物。

公开(公告)号：US08426405B2

公开(公告)日：2013-04-23

申请号：US12733994

申请日：2009-07-02

申请人： John Joseph Deadman ,  Eric Dale Jones ,  Giang Thanh Le ,  David Ian Rhodes ,  Neeranat Thienthong ,  Nicholas Andrew Vandegraaff ,  Lisa Jane Winfield

发明人： John Joseph Deadman ,  Eric Dale Jones ,  Giang Thanh Le ,  David Ian Rhodes ,  Neeranat Thienthong ,  Nicholas Andrew Vandegraaff ,  Lisa Jane Winfield

IPC分类号： A61K31/535 ,  C07D413/14

CPC分类号： C07D513/04

摘要： Compounds of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof are disclosed. Also disclosed are methods of treating a viral infection in a subject by administering to the subject an effective amount of a compound of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof. Pharmaceutical compositions comprising a compound of formula (I) are also provided.

摘要翻译： 公开了式（I）化合物或其药学上可接受的衍生物，盐或前药。 还公开了通过向受试者施用有效量的式（I）化合物或其药学上可接受的衍生物，盐或前药来治疗受试者的病毒感染的方法。 还提供了包含式（I）化合物的药物组合物。

公开(公告)号：US20110281861A1

公开(公告)日：2011-11-17

申请号：US12733994

申请日：2009-07-02

申请人： John Joseph Deadman ,  Eric Dale Jones ,  Giang Thanh Le ,  David Ian Rhodes ,  Neeranat Thienthong ,  Nicholas Andrew Vandegraaff ,  Lisa Jane Winfield

发明人： John Joseph Deadman ,  Eric Dale Jones ,  Giang Thanh Le ,  David Ian Rhodes ,  Neeranat Thienthong ,  Nicholas Andrew Vandegraaff ,  Lisa Jane Winfield

IPC分类号： A61K31/5377 ,  A61P31/18 ,  A61K31/519 ,  A61P31/12 ,  C07D495/04 ,  C07D413/14

CPC分类号： C07D513/04

摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof. The present invention further provides a method of treatment or prophylaxis of a viral infection in a subject comprising administering to said subject an effective amount of a compound of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof. Pharmaceutical compositions comprising a compound of formula (I) are also provided.

摘要翻译： 本发明提供式（I）化合物或其药学上可接受的衍生物，盐或前药。 本发明还提供了治疗或预防受试者病毒感染的方法，其包括向所述受试者施用有效量的式（I）化合物或其药学上可接受的衍生物，盐或前药。 还提供了包含式（I）化合物的药物组合物。

公开(公告)号：US20110009366A1

公开(公告)日：2011-01-13

申请号：US12766510

申请日：2010-04-23

申请人： Eric Dale Jones ,  Jonathan Alan Victor Coates ,  David Ian Rhodes ,  John Joseph Deadman ,  Nicholas Andrew Vandegraff ,  Lisa Jane Winfield ,  Neeranat Thienthong ,  William Issa ,  Neil Choi ,  Katherinie Macfarlane

发明人： Eric Dale Jones ,  Jonathan Alan Victor Coates ,  David Ian Rhodes ,  John Joseph Deadman ,  Nicholas Andrew Vandegraff ,  Lisa Jane Winfield ,  Neeranat Thienthong ,  William Issa ,  Neil Choi ,  Katherinie Macfarlane

IPC分类号： A61K31/519 ,  C07D471/04 ,  C07D491/048 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/675 ,  A61P31/12 ,  A61P31/18

CPC分类号： C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04

摘要： The present invention provides a compound of Formula I or a pharmaceutically acceptable derivative, salt or prodrug thereof. Further provided is a method of treatment or prophylaxis of a viral infection in a subject comprising administering to said subject an effective amount of a compound of Formula I or a pharmaceutically acceptable derivative, salt or prodrug thereof. A pharmaceutical composition or medicament comprising a compound of Formula I is also provided.

摘要翻译： 本发明提供式I化合物或其药学上可接受的衍生物，盐或前药。 还提供了治疗或预防受试者病毒感染的方法，包括向所述受试者施用有效量的式I化合物或其药学上可接受的衍生物，盐或前药。 还提供了包含式I化合物的药物组合物或药物。

公开(公告)号：US20100168063A1

公开(公告)日：2010-07-01

申请号：US12519273

申请日：2007-12-21

申请人： Eric Dale Jones ,  Jonathan Alan Coates ,  David Ian Rhodes ,  John Joseph Deadman ,  Nicholas Andrew Vandegraff ,  Lisa Jane Winfield ,  Neeranat Thienthong ,  William Issa ,  Neil Choi ,  Katherine MacFarlane

发明人： Eric Dale Jones ,  Jonathan Alan Coates ,  David Ian Rhodes ,  John Joseph Deadman ,  Nicholas Andrew Vandegraff ,  Lisa Jane Winfield ,  Neeranat Thienthong ,  William Issa ,  Neil Choi ,  Katherine MacFarlane

IPC分类号： A61K31/675 ,  C07D413/14 ,  C07F9/38 ,  C07D279/06 ,  C07D401/14 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/519 ,  A61P31/12 ,  A61P31/18

CPC分类号： C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04

摘要： The present invention provides a compound of Formula I or a pharmaceutically acceptable derivative, salt or prodrug thereof. Further provided is a method of treatment or prophylaxis of a viral infection in a subject comprising administering to said subject an effective amount of a compound of Formula I or a pharmaceutically acceptable derivative, salt or prodrug thereof. A pharmaceutical composition or medicament comprising a compound of Formula I is also provided.

摘要翻译： 本发明提供式I化合物或其药学上可接受的衍生物，盐或前药。 还提供了治疗或预防受试者病毒感染的方法，包括向所述受试者施用有效量的式I化合物或其药学上可接受的衍生物，盐或前药。 还提供了包含式I化合物的药物组合物或药物。

公开(公告)号：US20120232035A1

公开(公告)日：2012-09-13

申请号：US13405511

申请日：2012-02-27

申请人： Eric Dale Jones ,  Jonathan Alan Victor Coates ,  David Ian Rhodes ,  John Joseph Deadman ,  Nicholas Andrew Vandegraff ,  Lisa Jane Winfield ,  Neeranat Thienthong ,  William Issa ,  Neil Choi ,  Katherine Macfarlane

发明人： Eric Dale Jones ,  Jonathan Alan Victor Coates ,  David Ian Rhodes ,  John Joseph Deadman ,  Nicholas Andrew Vandegraff ,  Lisa Jane Winfield ,  Neeranat Thienthong ,  William Issa ,  Neil Choi ,  Katherine Macfarlane

IPC分类号： A61K31/519 ,  A61P31/14 ,  A61P31/12 ,  A61P31/18 ,  A61K31/5377 ,  A61K31/675

CPC分类号： C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04

摘要： The present invention provides a compound of Formula I or a pharmaceutically acceptable derivative, salt or prodrug thereof. Further provided is a method of treatment or prophylaxis of a viral infection in a subject comprising administering to said subject an effective amount of a compound of Formula I or a pharmaceutically acceptable derivative, salt or prodrug thereof. A pharmaceutical composition or medicament comprising a compound of Formula I is also provided.

摘要翻译： 本发明提供式I化合物或其药学上可接受的衍生物，盐或前药。 还提供了治疗或预防受试者病毒感染的方法，包括向所述受试者施用有效量的式I化合物或其药学上可接受的衍生物，盐或前药。 还提供了包含式I化合物的药物组合物或药物。

公开(公告)号：US08207334B2

公开(公告)日：2012-06-26

申请号：US12766510

申请日：2010-04-23

申请人： Eric Dale Jones ,  Jonathan Alan Victor Coates ,  David Ian Rhodes ,  John Joseph Deadman ,  Nicholas Andrew Vandegraff ,  Lisa Jane Winfield ,  Neeranat Thienthong ,  William Issa ,  Neil Choi ,  Katherinie Macfarlane

发明人： Eric Dale Jones ,  Jonathan Alan Victor Coates ,  David Ian Rhodes ,  John Joseph Deadman ,  Nicholas Andrew Vandegraff ,  Lisa Jane Winfield ,  Neeranat Thienthong ,  William Issa ,  Neil Choi ,  Katherinie Macfarlane

IPC分类号： C07D239/70 ,  C07D487/00

CPC分类号： C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04

摘要： The present invention provides a compound of Formula I or a pharmaceutically acceptable derivative, salt or prodrug thereof. Further provided is a method of treatment or prophylaxis of a viral infection in a subject comprising administering to said subject an effective amount of a compound of Formula I or a pharmaceutically acceptable derivative, salt or prodrug thereof. A pharmaceutical composition or medicament comprising a compound of Formula I is also provided.

公开(公告)号：US08143268B2

公开(公告)日：2012-03-27

申请号：US12519273

申请日：2007-12-21

申请人： Eric Dale Jones ,  Jonathan Alan Victor Coates ,  David Ian Rhodes ,  John Joseph Deadman ,  Nicholas Andrew Vandegraff ,  Lisa Jane Winfield ,  Neeranat Thienthong ,  William Issa ,  Neil Choi ,  Katherine Macfarlane

发明人： Eric Dale Jones ,  Jonathan Alan Victor Coates ,  David Ian Rhodes ,  John Joseph Deadman ,  Nicholas Andrew Vandegraff ,  Lisa Jane Winfield ,  Neeranat Thienthong ,  William Issa ,  Neil Choi ,  Katherine Macfarlane

IPC分类号： A01N43/42 ,  A61K31/44 ,  C07D475/00

CPC分类号： C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04

摘要： The present invention provides a compound of Formula I or a pharmaceutically acceptable derivative, salt or prodrug thereof. Further provided is a method of treatment or prophylaxis of a viral infection in a subject comprising administering to said subject an effective amount of a compound of Formula I or a pharmaceutically acceptable derivative, salt or prodrug thereof. A pharmaceutical composition or medicament comprising a compound of Formula I is also provided.