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公开(公告)号：US08431581B2
公开(公告)日：2013-04-30
申请号：US12734042
申请日：2009-07-02
申请人： John Joseph Deadman , Eric Dale Jones , Giang Thanh Le , David Ian Rhodes , Neeranat Thienthong , Nicholas Andrew Van de Graff , Lisa Jane Winfield
发明人： John Joseph Deadman , Eric Dale Jones , Giang Thanh Le , David Ian Rhodes , Neeranat Thienthong , Nicholas Andrew Van de Graff , Lisa Jane Winfield
IPC分类号： A01N43/90 , A61K31/519 , C07D487/00
CPC分类号： C07D487/04
摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof. The present invention further provides a method of treatment or prophylaxis of a viral infection in a subject comprising administering to said subject an effective amount of a compound of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof. Pharmaceutical compositions comprising a compound of formula (I) are also provided.
摘要翻译： 本发明提供式（I）化合物或其药学上可接受的衍生物，盐或前药。 本发明还提供了治疗或预防受试者病毒感染的方法，其包括向所述受试者施用有效量的式（I）化合物或其药学上可接受的衍生物，盐或前药。 还提供了包含式（I）化合物的药物组合物。
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公开(公告)号：US20110028487A1
公开(公告)日：2011-02-03
申请号：US12734042
申请日：2009-07-02
申请人： John Joseph Deadman , Eric Dale Jones , Giang Thanh Le , David Ian Rhodes , Neeranat Thienthong , Nicholas Andrew Van De Graff , Lisa Jane Winfield
发明人： John Joseph Deadman , Eric Dale Jones , Giang Thanh Le , David Ian Rhodes , Neeranat Thienthong , Nicholas Andrew Van De Graff , Lisa Jane Winfield
IPC分类号： A61K31/496 , C07D487/04 , A61K31/519 , A61P31/12
CPC分类号： C07D487/04
摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof. The present invention further provides a method of treatment or prophylaxis of a viral infection in a subject comprising administering to said subject an effective amount of a compound of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof. Pharmaceutical compositions comprising a compound of formula (I) are also provided.
摘要翻译： 本发明提供式（I）化合物或其药学上可接受的衍生物，盐或前药。 本发明还提供了治疗或预防受试者病毒感染的方法，其包括向所述受试者施用有效量的式（I）化合物或其药学上可接受的衍生物，盐或前药。 还提供了包含式（I）化合物的药物组合物。
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公开(公告)号：US20110039842A1
公开(公告)日：2011-02-17
申请号：US12734036
申请日：2009-07-02
申请人： John Joseph Deadman , Eric Dale Jones , Giang Thanh Le , David Ian Rhodes , Neeranat Theinthong , Nicholas Andrew Van de Graff , Lisa Jane Winfield
发明人： John Joseph Deadman , Eric Dale Jones , Giang Thanh Le , David Ian Rhodes , Neeranat Theinthong , Nicholas Andrew Van de Graff , Lisa Jane Winfield
IPC分类号： A61K31/5355 , C07D471/04 , A61P31/18 , A61P31/14 , A61K31/519
CPC分类号： C07D471/04
摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof. The present invention further provides a method of treatment or prophylaxis of a viral infection in a subject comprising administering to said subject an effective amount of a compound of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof. Pharmaceutical compositions comprising a compound of formula (I) are also provided.
摘要翻译： 本发明提供式（I）化合物或其药学上可接受的衍生物，盐或前药。 本发明还提供了治疗或预防受试者病毒感染的方法，其包括向所述受试者施用有效量的式（I）化合物或其药学上可接受的衍生物，盐或前药。 还提供了包含式（I）化合物的药物组合物。
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公开(公告)号：US20130059865A1
公开(公告)日：2013-03-07
申请号：US13614049
申请日：2012-09-13
申请人： John Joseph Deadman , Eric Dale Jones , Giang Thanh Le , David Ian Rhodes , Neeranat Theinthong , Nicholas Andrew Van de Graff , Lisa Jane Winfield
发明人： John Joseph Deadman , Eric Dale Jones , Giang Thanh Le , David Ian Rhodes , Neeranat Theinthong , Nicholas Andrew Van de Graff , Lisa Jane Winfield
IPC分类号： C07D471/04 , A61P31/14 , A61P31/18 , A61K31/519 , A61P31/12
CPC分类号： C07D471/04
摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof. The present invention further provides a method of treatment or prophylaxis of a viral infection in a subject comprising administering to said subject an effective amount of a compound of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof. Pharmaceutical compositions comprising a compound of formula (I) are also provided.
摘要翻译： 本发明提供式（I）化合物或其药学上可接受的衍生物，盐或前药。 本发明还提供了治疗或预防受试者病毒感染的方法，其包括向所述受试者施用有效量的式（I）化合物或其药学上可接受的衍生物，盐或前药。 还提供了包含式（I）化合物的药物组合物。
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公开(公告)号：US08563562B2
公开(公告)日：2013-10-22
申请号：US13614049
申请日：2012-09-13
申请人： John Joseph Deadman , Eric Dale Jones , Giang Thanh Le , David Ian Rhodes , Neeranat Theinthong , Nicholas Andrew Van de Graff , Lisa Jane Winfield
发明人： John Joseph Deadman , Eric Dale Jones , Giang Thanh Le , David Ian Rhodes , Neeranat Theinthong , Nicholas Andrew Van de Graff , Lisa Jane Winfield
IPC分类号： C07D471/04 , A61P31/14 , A61P31/18 , A61P31/12 , A61K31/519
CPC分类号： C07D471/04
摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof. The present invention further provides a method of treatment or prophylaxis of a viral infection in a subject comprising administering to said subject an effective amount of a compound of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof. Pharmaceutical compositions comprising a compound of formula (I) are also provided.
摘要翻译： 本发明提供式（I）化合物或其药学上可接受的衍生物，盐或前药。 本发明还提供了治疗或预防受试者病毒感染的方法，其包括向所述受试者施用有效量的式（I）化合物或其药学上可接受的衍生物，盐或前药。 还提供了包含式（I）化合物的药物组合物。
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公开(公告)号：US08426405B2
公开(公告)日：2013-04-23
申请号：US12733994
申请日：2009-07-02
申请人： John Joseph Deadman , Eric Dale Jones , Giang Thanh Le , David Ian Rhodes , Neeranat Thienthong , Nicholas Andrew Vandegraaff , Lisa Jane Winfield
发明人： John Joseph Deadman , Eric Dale Jones , Giang Thanh Le , David Ian Rhodes , Neeranat Thienthong , Nicholas Andrew Vandegraaff , Lisa Jane Winfield
IPC分类号： A61K31/535 , C07D413/14
CPC分类号： C07D513/04
摘要： Compounds of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof are disclosed. Also disclosed are methods of treating a viral infection in a subject by administering to the subject an effective amount of a compound of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof. Pharmaceutical compositions comprising a compound of formula (I) are also provided.
摘要翻译： 公开了式（I）化合物或其药学上可接受的衍生物，盐或前药。 还公开了通过向受试者施用有效量的式（I）化合物或其药学上可接受的衍生物，盐或前药来治疗受试者的病毒感染的方法。 还提供了包含式（I）化合物的药物组合物。
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公开(公告)号：US20110281861A1
公开(公告)日：2011-11-17
申请号：US12733994
申请日：2009-07-02
申请人： John Joseph Deadman , Eric Dale Jones , Giang Thanh Le , David Ian Rhodes , Neeranat Thienthong , Nicholas Andrew Vandegraaff , Lisa Jane Winfield
发明人： John Joseph Deadman , Eric Dale Jones , Giang Thanh Le , David Ian Rhodes , Neeranat Thienthong , Nicholas Andrew Vandegraaff , Lisa Jane Winfield
IPC分类号： A61K31/5377 , A61P31/18 , A61K31/519 , A61P31/12 , C07D495/04 , C07D413/14
CPC分类号： C07D513/04
摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof. The present invention further provides a method of treatment or prophylaxis of a viral infection in a subject comprising administering to said subject an effective amount of a compound of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof. Pharmaceutical compositions comprising a compound of formula (I) are also provided.
摘要翻译： 本发明提供式（I）化合物或其药学上可接受的衍生物，盐或前药。 本发明还提供了治疗或预防受试者病毒感染的方法，其包括向所述受试者施用有效量的式（I）化合物或其药学上可接受的衍生物，盐或前药。 还提供了包含式（I）化合物的药物组合物。
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公开(公告)号：US20130178469A1
公开(公告)日：2013-07-11
申请号：US13807420
申请日：2011-07-15
申请人： David Ian Rhodes , John Joseph Deadman , Giang Thanh Le , Nicholas Andrew Van de Graff , Lu Long , Li Xinming , Feng Xiao , Yu Changjiang
发明人： David Ian Rhodes , John Joseph Deadman , Giang Thanh Le , Nicholas Andrew Van de Graff , Lu Long , Li Xinming , Feng Xiao , Yu Changjiang
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , C07D487/04
摘要： The present invention provides a compound of Formula I or a pharmaceutically acceptable derivative, salt or prodrug thereof. Further provided is a method of treatment or prophylaxis of a viral infection in a subject comprising administering to said subject an effective amount of a compound of Formula I or a pharmaceutically acceptable derivative, salt or prodrug thereof. A pharmaceutical composition or medicament comprising a compound of Formula I is also provided
摘要翻译： 本发明提供式I化合物或其药学上可接受的衍生物，盐或前药。 还提供了治疗或预防受试者病毒感染的方法，包括向所述受试者施用有效量的式I化合物或其药学上可接受的衍生物，盐或前药。 还提供了包含式I化合物的药物组合物或药物
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公开(公告)号：US20060121530A1
公开(公告)日：2006-06-08
申请号：US10513286
申请日：2003-04-24
申请人： Wim Meutermans , Michael West , George Adamson , Giang Thanh Le , Nicholas Drinnan , Giovani Abbenante , Bernd Becker , Matthias Grathwohl , Premraj Rajaratnam , Gerald Tometzki
发明人： Wim Meutermans , Michael West , George Adamson , Giang Thanh Le , Nicholas Drinnan , Giovani Abbenante , Bernd Becker , Matthias Grathwohl , Premraj Rajaratnam , Gerald Tometzki
摘要： Methods are described for the preparation of combinatorial libraries of potentially biologically active disaccharide compounds. These compounds are variously functionalized, with a view to varying lipid solubility size, function an other properties, with the particular aim of discovering novel drug or drug-like compounds, or compounds with useful properties. The invention provides intermediates, processes and synthetic strategies for the solution or solid phase synthesis of disaccharides, variously functionalized about the sugar ring, including the addition of aromaticity and charge, and the placement of pharmaceutically useful groups and isosteres.
摘要翻译： 描述了用于制备潜在的生物活性二糖化合物的组合文库的方法。 为了改变脂质溶解度大小，这些化合物被多种功能化，起到其它特性的作用，特别是发现新的药物或药物样化合物或具有有用特性的化合物。 本发明提供了关于糖环的各种功能化的二糖的溶液或固相合成的中间体，方法和合成策略，包括添加芳香性和电荷，以及放置药学上有用的基团和等体积体。
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公开(公告)号：US20110201794A1
公开(公告)日：2011-08-18
申请号：US12926913
申请日：2010-12-17
申请人： Wim Meutermans , Michael L. West , George Adamson , Giang Thanh Le , Nicholas B. Drinnan , Giovani Abbenante , Bernd Becker , Matthias Grathwohl , Premraj Rajaratnam , Gerald Tometzki
发明人： Wim Meutermans , Michael L. West , George Adamson , Giang Thanh Le , Nicholas B. Drinnan , Giovani Abbenante , Bernd Becker , Matthias Grathwohl , Premraj Rajaratnam , Gerald Tometzki
摘要： Methods are described for the preparation of combinatorial libraries of potentially biologically active disaccharide compounds. These compounds are variously functionalized, with a view to varying lipid solubility size, function an other properties, with the particular aim of discovering novel drug or drug-like compounds, or compounds with useful properties. The invention provides intermediates, processes and synthetic strategies for the solution or solid phase synthesis of disaccharides, variously functionalized about the sugar ring, including the addition of aromaticity and charge, and the placement of pharmaceutically useful groups and isosteres.
摘要翻译： 描述了用于制备潜在的生物活性二糖化合物的组合文库的方法。 为了改变脂质溶解度大小，这些化合物被多种功能化，起到其它特性的作用，特别是发现新的药物或药物样化合物或具有有用特性的化合物。 本发明提供了关于糖环的各种功能化的二糖的溶液或固相合成的中间体，方法和合成策略，包括添加芳香性和电荷，以及放置药学上有用的基团和等体积体。
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