公开(公告)号：US20150150681A1

公开(公告)日：2015-06-04

申请号：US14402737

申请日：2013-05-30

申请人： John L. Ricci ,  Elizabeth Clark ,  Paulo Coelho ,  Elizabeth Dianne Rekow ,  James Smay ,  Van P. Thompson

发明人： John L. Ricci ,  Elizabeth Clark ,  Paulo Coelho ,  Elizabeth Dianne Rekow ,  James Smay ,  Van P. Thompson

IPC分类号： A61F2/28 ,  A61L27/54 ,  A61L27/56 ,  B33Y80/00

CPC分类号： A61F2/28 ,  A61F2/2875 ,  A61F2/3094 ,  A61F2002/2817 ,  A61F2002/30011 ,  A61F2002/30235 ,  A61F2002/30574 ,  A61F2002/3092 ,  A61F2002/30962 ,  A61F2002/30968 ,  A61F2002/30985 ,  A61F2310/00179 ,  A61L27/025 ,  A61L27/54 ,  A61L27/56 ,  A61L2430/02 ,  B33Y80/00

摘要： The present invention relates to multiphasic, three-dimensionally printed, tissue repair devices or scaffolds useful for promoting bone growth and treating bone fracture, defect or deficiency, methods for making the same and methods for promoting bone growth and treating bone fracture, defect or deficiency using the same. The scaffold has a porous bone ingrowth area containing interconnected struts surrounded by a microporous shell. At the ends of the scaffold, the shell may be extended as a guide flange to stabilize the scaffold between ends of bone. The center of the scaffold may be empty and may serve as a potential marrow space. The porous ingrowth structure may be infiltrated with a soluble filler or carrier, such as, for example calcium sulfate which may be infiltrated with one or more of an antibiotic, a growth factor, a differentiation factors, a cytokine, a drug, or a combination of these agents.

摘要翻译： 本发明涉及可用于促进骨生长和治疗骨折，缺陷或不足的多相，三维印刷的组织修复装置或支架，其制备方法以及用于促进骨生长和治疗骨折，缺陷或缺陷的方法 使用相同 支架具有多孔骨向内生长区，其包含由微孔壳包围的相互连接的支柱。 在支架的端部，壳可以作为引导凸缘延伸，以在骨的端部之间稳定支架。 脚手架的中心可能是空的，可以作为潜在的骨髓空间。 多孔向内生长结构可以用可溶性填料或载体渗透，例如硫酸钙，其可以用抗生素，生长因子，分化因子，细胞因子，药物或组合中的一种或多种渗透 的这些药剂。

公开(公告)号：US08951597B2

公开(公告)日：2015-02-10

申请号：US12927137

申请日：2010-11-08

申请人： Yu Zhang ,  Jae-Won Kim ,  Van P. Thompson

发明人： Yu Zhang ,  Jae-Won Kim ,  Van P. Thompson

IPC分类号： A61L33/00 ,  A61C13/083 ,  C03C14/00

CPC分类号： A61C13/083 ,  C03C14/00

摘要： The present invention provides a functionally graded glass/ceramic/glass sandwich system especially useful in damage resistant, ceramic dental and orthopedic prosthesis. The functionally graded glass/substrate/glass composite structure comprises an outer (aesthetic) residual glass layer, a graded glass-ceramic layer, and a dense interior ceramic. The functionally graded glass/substrate/glass composite structure may further comprise a veneer on an exterior surface. The present invention also provides a method for preparing a functionally graded glass/ceramic/glass sandwich system. A powdered glass-ceramic composition or a glass tape is applied to the accessible surfaces of a dense alumina substrate to thereby substantially cover the substrate surfaces. The glass of the composition has a CTE similar to that of the substrate material. The glass-ceramic composition is infiltrated into the dense substrate by heating the assembly to temperatures 50-700° C. below the sintering temperature of the substrate.

摘要翻译： 本发明提供了一种功能梯度的玻璃/陶瓷/玻璃夹层系统，特别适用于耐损伤陶瓷牙科和矫形假体。 功能梯度的玻璃/基底/玻璃复合结构包括外部（美观的）残余玻璃层，梯度玻璃陶瓷层和致密的内部陶瓷。 功能梯度的玻璃/基底/玻璃复合结构还可以在外表面上包括单板。 本发明还提供了制备功能梯度玻璃/陶瓷/玻璃夹心系统的方法。 将粉末状玻璃陶瓷组合物或玻璃带施加到致密氧化铝基板的可接近表面，从而基本上覆盖基板表面。 组合物的玻璃具有与基材材料相似的CTE。 通过将组件加热到低于衬底的烧结温度50-700℃的温度下，将玻璃 - 陶瓷组合物渗透到致密衬底中。

公开(公告)号：US5460593A

公开(公告)日：1995-10-24

申请号：US111527

申请日：1993-08-25

申请人： Barry Mersky ,  Van P. Thompson

发明人： Barry Mersky ,  Van P. Thompson

IPC分类号： H04R25/00

CPC分类号： H04R25/606

摘要： Vibrations for application to hard living tissue, such as bones, teeth, etc., are derived from a magnetostrictive element disposed in a varying electromagnetic field to create dimensional variations in the magnetostrictive element. In an audiodontic vibrator for the hearing impaired, a magnetostrictive rod is disposed in the hollow core of an electromagnetic coil through which current flows in response to acoustic signals. The resulting electromagnetic field in the core passes through the magnetostrictive rod, causing small dimensional variations in the rod corresponding to amplitude variations in the field. An actuator in contact with the rod extends from the housing and transmits the dimensional changes as low amplitude vibrations to the hard tissue via a bracket mounted on a tooth by an adhesive resin-based cement. The bracket has a receiving channel contoured to slidably and removably receive the distal end of the actuator in close fitting frictional relation. When secured to bone tissue the preferred cement is a non-ceramic hydroxyapatite cement. In either case, the applied vibrations create cyclical strain in the hard tissue.

摘要翻译： 用于施加到硬的生物体组织（例如骨骼，牙齿等）上的振动源自设置在变化的电磁场中的磁致伸缩元件以产生磁致伸缩元件的尺寸变化。 在用于听力受损的听觉振动器中，磁致伸缩杆设置在电磁线圈的中空磁芯中，电磁线圈响应于声信号流过电磁线圈。 芯体中产生的电磁场通过磁致伸缩杆，引起棒中的尺寸变化与场中的振幅变化相对应。 与杆接触的致动器从壳体延伸并且通过基于粘合剂树脂的水泥通过安装在牙齿上的支架将尺寸变化作为低振幅振动传递到硬组织。 支架具有接收通道，其形状可滑动地并且可拆卸地以紧密配合的摩擦关系接收致动器的远端。 当固定到骨组织时，优选的水泥是非陶瓷羟基磷灰石水泥。 在任一情况下，所施加的振动在硬组织中产生周期性应变。

公开(公告)号：US20110123956A1

公开(公告)日：2011-05-26

申请号：US12927137

申请日：2010-11-08

申请人： Yu Zhang ,  Jae-Won Kim ,  Van P. Thompson

发明人： Yu Zhang ,  Jae-Won Kim ,  Van P. Thompson

IPC分类号： A61C13/08 ,  B32B17/06 ,  A61L27/30

CPC分类号： A61C13/083 ,  C03C14/00

摘要： The present invention provides a functionally graded glass/ceramic/glass sandwich system especially useful in damage resistant, ceramic dental and orthopedic prosthesis. The functionally graded glass/substrate/glass composite structure comprises an outer (aesthetic) residual glass layer, a graded glass-ceramic layer, and a dense interior ceramic. The functionally graded glass/substrate/glass composite structure may further comprise a veneer on an exterior surface. The present invention also provides a method for preparing a functionally graded glass/ceramic/glass sandwich system. A powdered glass-ceramic composition or a glass tape is applied to the accessible surfaces of a dense alumina substrate to thereby substantially cover the substrate surfaces. The glass of the composition has a CTE similar to that of the substrate material. The glass-ceramic composition is infiltrated into the dense substrate by heating the assembly to temperatures 50-700° C. below the sintering temperature of the substrate.

摘要翻译： 本发明提供了一种功能梯度的玻璃/陶瓷/玻璃夹层系统，特别适用于耐损伤陶瓷牙科和矫形假体。 功能梯度的玻璃/基底/玻璃复合结构包括外部（美观的）残余玻璃层，梯度玻璃陶瓷层和致密的内部陶瓷。 功能梯度的玻璃/基底/玻璃复合结构还可以在外表面上包括单板。 本发明还提供了制备功能梯度玻璃/陶瓷/玻璃夹心系统的方法。 将粉末状玻璃陶瓷组合物或玻璃带施加到致密氧化铝基板的可接近表面，从而基本上覆盖基板表面。 组合物的玻璃具有与基材材料相似的CTE。 通过将组件加热到低于衬底的烧结温度50-700℃的温度下，将玻璃 - 陶瓷组合物渗透到致密衬底中。

公开(公告)号：US07858192B2

公开(公告)日：2010-12-28

申请号：US11986290

申请日：2007-11-20

申请人： Yu Zhang ,  Jae-Won Kim ,  Van P. Thompson

发明人： Yu Zhang ,  Jae-Won Kim ,  Van P. Thompson

IPC分类号： B32B17/06

CPC分类号： A61C13/083 ,  C03C14/00

摘要： The present invention provides a functionally graded glass/ceramic/glass sandwich system especially useful in damage resistant, ceramic dental and orthopedic prosthesis. The functionally graded glass/substrate/glass composite structure comprises an outer (aesthetic) residual glass layer, a graded glass-ceramic layer, and a dense interior ceramic. The functionally graded glass/substrate/glass composite structure may further comprise a veneer on an exterior surface. The present invention also provides a method for preparing a functionally graded glass/ceramic/glass sandwich system. A powdered glass-ceramic composition or a glass tape is applied to the accessible surfaces of a dense alumina substrate to thereby substantially cover the substrate surfaces. The glass of the composition has a CTE similar to that of the substrate material. The glass-ceramic composition is infiltrated into the dense substrate by heating the assembly to temperatures 50-700° C. below the sintering temperature of the substrate.

摘要翻译： 本发明提供了一种功能梯度的玻璃/陶瓷/玻璃夹层系统，特别适用于耐损伤陶瓷牙科和矫形假体。 功能梯度的玻璃/基底/玻璃复合结构包括外部（美观的）残余玻璃层，梯度玻璃陶瓷层和致密的内部陶瓷。 功能梯度的玻璃/基底/玻璃复合结构还可以在外表面上包括单板。 本发明还提供了制备功能梯度玻璃/陶瓷/玻璃夹心系统的方法。 将粉末状玻璃陶瓷组合物或玻璃带施加到致密氧化铝基板的可接近表面，从而基本上覆盖基板表面。 组合物的玻璃具有与基材材料相似的CTE。 通过将组件加热到低于衬底的烧结温度50-700℃的温度下，将玻璃 - 陶瓷组合物渗透到致密衬底中。

公开(公告)号：US20080213727A1

公开(公告)日：2008-09-04

申请号：US11986290

申请日：2007-11-20

申请人： Yu Zhang ,  Jae-Won Kim ,  Van P. Thompson

发明人： Yu Zhang ,  Jae-Won Kim ,  Van P. Thompson

IPC分类号： A61C13/08 ,  C03C14/00

CPC分类号： A61C13/083 ,  C03C14/00

摘要： The present invention provides a functionally graded glass/ceramic/glass sandwich system especially useful in damage resistant, ceramic dental and orthopedic prosthesis. The functionally graded glass/substrate/glass composite structure comprises an outer (aesthetic) residual glass layer, a graded glass-ceramic layer, and a dense interior ceramic. The functionally graded glass/substrate/glass composite structure may further comprise a veneer on an exterior surface. The present invention also provides a method for preparing a functionally graded glass/ceramic/glass sandwich system. A powdered glass-ceramic composition or a glass tape is applied to the accessible surfaces of a dense alumina substrate to thereby substantially cover the substrate surfaces. The glass of the composition has a CTE similar to that of the substrate material. The glass-ceramic composition is infiltrated into the dense substrate by heating the assembly to temperatures 50-700° C. below the sintering temperature of the substrate.

摘要翻译： 本发明提供了一种功能梯度的玻璃/陶瓷/玻璃夹层系统，特别适用于耐损伤陶瓷牙科和矫形假体。 功能梯度的玻璃/基底/玻璃复合结构包括外部（美观的）残余玻璃层，梯度玻璃陶瓷层和致密的内部陶瓷。 功能梯度的玻璃/基底/玻璃复合结构还可以在外表面上包括单板。 本发明还提供了制备功能梯度玻璃/陶瓷/玻璃夹心系统的方法。 将粉末状玻璃陶瓷组合物或玻璃带施加到致密氧化铝基板的可接近表面，从而基本上覆盖基板表面。 组合物的玻璃具有与基材材料相似的CTE。 通过将组件加热到低于衬底的烧结温度50-700℃的温度下，将玻璃 - 陶瓷组合物渗透到致密衬底中。

公开(公告)号：US5455842A

公开(公告)日：1995-10-03

申请号：US181149

申请日：1994-01-12

申请人： Barry Mersky ,  Van P. Thompson

发明人： Barry Mersky ,  Van P. Thompson

IPC分类号： A62B18/08 ,  B63C11/26 ,  H04B11/00 ,  H04B13/02 ,  H04R1/00 ,  H04R1/44 ,  H04M1/60 ,  H04R25/00

CPC分类号： B63C11/26 ,  H04B11/00 ,  H04B13/02 ,  H04R1/44

摘要： Waterborne acoustic signals are received and processed into electrical driver signals to energize a transducer held in selectively controllable vibration-transmitting engagement with a tooth of an underwater diver. The transducer converts the electrical signals into low amplitude sound-associated vibrations imparted to the tooth, through the jawbone and scull to the cochlea for processing into electrical signals carried to the brain and perceived as intelligible sound. The addition of conventional broadcast means permits two-way underwater communication. The transducer can be labially or occlusively mounted, preferably against an upper or maxillary tooth and the force of engagement between the transducer and the tooth is at least partially controlled by the diver to optimize communication characteristics.

摘要翻译： 水声信号被接收并处理成电驱动器信号，以激励保持与水下潜水员的牙齿有选择地可控振动传递接合的换能器。 换能器将电信号转换成通过颚骨传递给牙齿的低振幅声音相关的振动，并且到达耳蜗，以便处理成被传送到大脑的电信号并被感知为可理解的声音。 常规广播方式的增加允许双向水下通信。 传感器可以是阴性或封闭地安装，优选地抵抗上或上颌齿，并且换能器和牙齿之间的接合力至少部分地由潜水员控制以优化通信特性。