公开(公告)号：US06420365B1

公开(公告)日：2002-07-16

申请号：US09765159

申请日：2001-01-17

申请人： John M. Peterson ,  Alan Hutchison ,  Kenneth Shaw ,  Kevin Hodgetts ,  George D. Maynard ,  Richard Lew

发明人： John M. Peterson ,  Alan Hutchison ,  Kenneth Shaw ,  Kevin Hodgetts ,  George D. Maynard ,  Richard Lew

IPC分类号： A61K31435

CPC分类号： C07D471/04

摘要： Disclosed are compounds of the formula: or the pharmaceutically acceptable non-toxic salts thereof wherein A, B, C, D, Y, R1, R3, R4, R5, and R6 are variables defined herein, which compounds are modulators of Bradykinin B2 receptors. These compounds are useful in the diagnosis and treatment of renal diseases, heart failure, hypertension, Meniere's disease, vaginal inflammation and pain, peripheral circulatory disorders, climacteric disturbance, retinochoroidal circulatory disorders, myocardial ischemia, myocardial infarction, postmyocardial infarction syndrome, angina pectoris, restenosis after percutaneous transluminal coronary angioplasty, hepatitis, liver cirrhosis, pancreatitis, ileus, diabetes, diabetic complications, male infertility, glaucoma, pain, asthma, and rhinitis and for the increase of permeability of the blood-brain barrier or the blood-brain-tumor barrier.

摘要翻译： 公开了下式的化合物或其药学上可接受的无毒性盐，其中A，B，C，D，Y，R 1，R 3，R 4，R 5和R 6是本文定义的变量，该化合物是缓激肽B2受体的调节剂 。 这些化合物可用于诊断和治疗肾脏疾病，心力衰竭，高血压，梅尼埃病，阴道炎症和疼痛，外周循环障碍，更年期障碍，视网膜循环障碍，心肌缺血，心肌梗死，心肌梗死后综合征，心绞痛， 经皮腔内冠状动脉血管成形术，肝炎，肝硬化，胰腺炎，肠梗阻，糖尿病，糖尿病并发症，男性不育症，青光眼，疼痛，哮喘和鼻炎的再狭窄，以及增加血脑屏障或血脑屏障的渗透性， 肿瘤屏障。

公开(公告)号：US06358949B1

公开(公告)日：2002-03-19

申请号：US09540580

申请日：2000-03-31

申请人： Robert W. DeSimone ,  Alan Hutchison ,  Kenneth Shaw ,  George D. Maynard ,  John M. Peterson ,  Richard Lew ,  Harry L. Brielmann

发明人： Robert W. DeSimone ,  Alan Hutchison ,  Kenneth Shaw ,  George D. Maynard ,  John M. Peterson ,  Richard Lew ,  Harry L. Brielmann

IPC分类号： A61K315377

CPC分类号： C07D471/04

摘要： Disclosed are compounds of the formula: or the pharmaceutically acceptable non-toxic salts thereof wherein: A, B, C and D are N or CH; X is a bond or (un)substituted CH2; R1 is lower alkenyl or (un)substituted lower alkyl; R3 is lower alkyl; and R2, R4, R5, and R6 are variables defined herein; which compounds are useful in the diagnosis and treatment of renal diseases, heart failure, hypertension, Meniere's disease, vaginal inflammation and pain, peripheral circulatory disorders, climacteric disturbance, retinochoroidal circulatroy disorders, myocardial ischemia, myocardial infarction, postmyocardial infarction syndrome, angina pectoris, restenosis after percutaneous transluminal coronary angioplasty, hepatitis, liver cirrhosis, pancreatitis, ileus, diabetes, diabetic complications, male infertility or glaucoma, or for the increase of permeability of blood-brain barrier, pain, asthma, and rhinitis.

摘要翻译： 公开了下式的化合物或其药学上可接受的无毒盐，其中：A，B，C和D是N或CH; X是一个或（un）取代的CH 2; R 1是低级烯基或（取代） 低级烷基; R3是低级烷基; 和R2，R4，R5和R6是本文定义的变量;这些化合物可用于诊断和治疗肾脏疾病，心力衰竭，高血压，梅尼埃病，阴道炎症和疼痛，外周循环障碍，更年期障碍，视网膜循环障碍， 心肌缺血，心肌梗死，心肌梗死后综合征，心绞痛，经皮腔内冠状动脉成形术后再狭窄，肝炎，肝硬化，胰腺炎，肠梗阻，糖尿病，糖尿病并发症，男性不育症或青光眼，或增加血脑屏障通透性 ，疼痛，哮喘和鼻炎。

公开(公告)号：US06592185B2

公开(公告)日：2003-07-15

申请号：US10072304

申请日：2002-02-07

申请人： Richard Lew

发明人： Richard Lew

IPC分类号： A47C102

CPC分类号： A61G15/00 ,  A61G15/02 ,  A61G15/12 ,  A61G15/125 ,  A61G2203/12

摘要： A seating device for maneuvering a body part comprising a fully adjustable chair including a base assembly, an occupant supporting assembly and an elevator assembly including drive mechanisms for raising, lowering and tilting the occupant supporting assembly. The chair has a head rest, leg rest, chest rest and a plurality of arm rests. The chair has full adjustment in all axes: rotation around a vertical central axis; vertical height adjustment; fully adjustable seat back for proper lumbar support; and tilt of the seat. The base assembly includes a power unit biased toward the floor. The chair permits support of the occupant with a full range of adjustment so that the occupant can have proper positioning for selected medical procedures and body part positions.

摘要翻译： 一种用于操纵身体部分的座椅装置，其包括完全可调节的椅子，其包括基座组件，乘员支撑组件和包括用于升高，降低和倾斜乘员支撑组件的驱动机构的升降机组件。 椅子有一个头枕，休息，胸部休息和多个扶手。 椅子在所有轴上进行全面调整：围绕垂直中心轴旋转; 垂直高度调整; 完全可调的座椅靠背适合腰部支撑; 并倾斜座椅。 基座组件包括偏向地板的动力单元。 椅子允许乘客进行全面的调整，以便乘客能够对选定的医疗程序和身体部位进行适当的定位。