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公开(公告)号：US07687461B2
公开(公告)日：2010-03-30
申请号：US10963994
申请日：2004-10-12
申请人： John R. Desjarlais , Anton Filikov , Paul Michael Steed , Jonathan Zalevsky , David Edmund Szymkowski
发明人： John R. Desjarlais , Anton Filikov , Paul Michael Steed , Jonathan Zalevsky , David Edmund Szymkowski
IPC分类号： A61K38/19 , C07K14/525
CPC分类号： C07K14/525 , A61K38/191 , C07K14/70575
摘要： The invention relates to novel proteins with TNF-alpha antagonist activity and nucleic acids encoding these proteins. The invention further relates to the use of the novel proteins in the treatment of TNF-alpha related disorders.
摘要翻译： 本发明涉及具有TNF-α拮抗剂活性的新型蛋白质和编码这些蛋白质的核酸。 本发明还涉及新型蛋白质在治疗TNF-α相关疾病中的用途。
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2.发明授权TNF-alpha variants proteins for the treatment of TNF-alpha related disorders 有权TNF-α变体蛋白用于治疗TNF-α相关疾病公开(公告)号：US07244823B2
公开(公告)日：2007-07-17
申请号：US10262630
申请日：2002-09-30
申请人： Bassil I. Dahiyat , John R. Desjarlais , Anton Filikov , Umesh Muchhal , Malu Lourdes G. Tansey , Jonathan Zalevsky
发明人： Bassil I. Dahiyat , John R. Desjarlais , Anton Filikov , Umesh Muchhal , Malu Lourdes G. Tansey , Jonathan Zalevsky
CPC分类号： A61K38/191 , C07K14/525
摘要： The invention relates to novel proteins with TNF-alpha antagonist activity and nucleic acids encoding these proteins. The invention further relates to the use of the novel proteins in the treatment of TNF-alpha related disorders.
摘要翻译： 本发明涉及具有TNF-α拮抗剂活性的新型蛋白质和编码这些蛋白质的核酸。 本发明还涉及新型蛋白质在治疗TNF-α相关疾病中的用途。
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公开(公告)号：US20060257360A1
公开(公告)日：2006-11-16
申请号：US11495220
申请日：2006-07-27
CPC分类号： C07K14/525 , A61K38/191 , C07K14/70575
摘要： The invention relates to novel proteins with TNF-alpha antagonist activity and nucleic acids encoding these proteins. The invention further relates to the use of the novel proteins in the treatment of TNF-alpha related disorders.
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4.发明申请TNF-alpha VARIANTS PROTEINS FOR THE TREATMENT OF TNF-alpha RELATED DISORDERS 审中-公开用于治疗TNF-α相关疾病的TNF-α变体蛋白公开(公告)号：US20070207961A1
公开(公告)日：2007-09-06
申请号：US11693318
申请日：2007-03-29
申请人： Bassil Dahiyat , John Desjarlais , Anton Filikov , Umesh Muchhal , Malu Tansey , Jonathan Zalevsky
发明人： Bassil Dahiyat , John Desjarlais , Anton Filikov , Umesh Muchhal , Malu Tansey , Jonathan Zalevsky
IPC分类号： A61K38/16
CPC分类号： A61K38/191 , C07K14/525
摘要： The invention relates to novel proteins with TNF-alpha antagonist activity and nucleic acids encoding these proteins. The invention further relates to the use of the novel proteins in the treatment of TNF-alpha related disorders.
摘要翻译： 本发明涉及具有TNF-α拮抗剂活性的新型蛋白质和编码这些蛋白质的核酸。 本发明还涉及新型蛋白质在治疗TNF-α相关疾病中的用途。
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公开(公告)号：US20050180948A1
公开(公告)日：2005-08-18
申请号：US10963994
申请日：2004-10-12
IPC分类号： A61K38/00 , C07K14/525 , C07K14/705 , A61K38/19
CPC分类号： C07K14/525 , A61K38/191 , C07K14/70575
摘要： The invention relates to novel proteins with TNF-alpha antagonist activity and nucleic acids encoding these proteins. The invention further relates to the use of the novel proteins in the treatment of TNF-alpha related disorders.
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公开(公告)号：US20120108574A1
公开(公告)日：2012-05-03
申请号：US13286294
申请日：2011-11-01
申请人： Mark A. Ashwell , Sudharshan Eathiraj , Anton Filikov , Steffi Koerner , Jean-Marc Lapierre , Yanbin Liu , Rocio Palma , David Vensel , Shin Iimura , Akiko Shiina , Kenichi Yoshida , Takanori Yamazaki , Akihisa Matsuda
发明人： Mark A. Ashwell , Sudharshan Eathiraj , Anton Filikov , Steffi Koerner , Jean-Marc Lapierre , Yanbin Liu , Rocio Palma , David Vensel , Shin Iimura , Akiko Shiina , Kenichi Yoshida , Takanori Yamazaki , Akihisa Matsuda
IPC分类号： A61K31/551 , A61P35/00 , C07D487/14
CPC分类号： C07D471/14 , A61K31/551 , Y02A50/401 , Y02A50/409 , Y02A50/411
摘要： The present invention relates to substituted benzo-imidazo-pyrido-diazepine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted benzo-imidazo-pyrido-diazepine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.
摘要翻译： 本发明涉及取代的苯并咪唑并 - 吡啶并二氮杂化合物及其合成方法。 本发明还涉及含有取代的苯并咪唑并 - 吡啶并二氮杂化合物的药物组合物和通过将这些化合物和药物组合物给予有需要的受试者来治疗细胞增殖性疾病如癌症的方法。
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公开(公告)号：US20110172203A1
公开(公告)日：2011-07-14
申请号：US12981127
申请日：2010-12-29
申请人： Mark A. Ashwell , Chris Brassard , Anton Filikov , Jason Hill , Steffi Koerner , Jean-Marc Lapierre , Yanbin Liu , Nivedita Namdev , Robert Nicewonger , Rocio Palma , Manish Tandon , David Vensel , Akihisa Matsuda , Shin Iimura , Yuko Yamamoto
发明人： Mark A. Ashwell , Chris Brassard , Anton Filikov , Jason Hill , Steffi Koerner , Jean-Marc Lapierre , Yanbin Liu , Nivedita Namdev , Robert Nicewonger , Rocio Palma , Manish Tandon , David Vensel , Akihisa Matsuda , Shin Iimura , Yuko Yamamoto
IPC分类号： A61K31/397 , C07D471/04 , A61K31/437 , C07D401/14 , A61K31/506 , A61K31/497 , C07D413/14 , A61K31/5377 , A61K31/538 , A61K31/553 , A61K31/496 , A61K31/438 , A61P35/00
CPC分类号： C07D471/04
摘要： The present invention relates to substituted imidazopyridinyl-aminopyridine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted imidazopyridinyl-aminopyridine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.
摘要翻译： 本发明涉及取代的咪唑并吡啶基 - 氨基吡啶化合物和合成这些化合物的方法。 本发明还涉及含有取代的咪唑并吡啶基 - 氨基吡啶化合物的药物组合物和通过将这些化合物和药物组合物施用于有需要的受试者来治疗细胞增殖性疾病如癌症的方法。
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![Substituted benzo[f]lmidazo[1,2-d]pyrido[2,3-b][1,4]diazepine compounds](/abs-image/US/2013/10/29/US08569331B2/abs.jpg.150x150.jpg)
8.发明授权Substituted benzo[f]lmidazo[1,2-d]pyrido[2,3-b][1,4]diazepine compounds 有权取代的苯并[f]咪唑并[1,2-d]吡啶并[2,3-b] [1,4]二氮杂化合物公开(公告)号：US08569331B2
公开(公告)日：2013-10-29
申请号：US13286294
申请日：2011-11-01
申请人： Mark A. Ashwell , Sudharshan Eathiraj , Anton Filikov , Steffi Koerner , Jean-Marc Lapierre , Yanbin Liu , Rocio Palma , David Vensel , Shin Iimura , Akiko Shiina , Kenichi Yoshida , Takanori Yamazaki , Akihisa Matsuda
发明人： Mark A. Ashwell , Sudharshan Eathiraj , Anton Filikov , Steffi Koerner , Jean-Marc Lapierre , Yanbin Liu , Rocio Palma , David Vensel , Shin Iimura , Akiko Shiina , Kenichi Yoshida , Takanori Yamazaki , Akihisa Matsuda
IPC分类号： A61K31/44
CPC分类号： C07D471/14 , A61K31/551 , Y02A50/401 , Y02A50/409 , Y02A50/411
摘要： The present invention relates to substituted benzo[f]imidazo[1,2-d]pyrido[2,3-b][1,4]diazepine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted benzo[f]imidazo[1,2-d]pyrido[2,3-b][1,4]diazepine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.
摘要翻译： 本发明涉及取代的苯并[f]咪唑并[1,2-d]吡啶并[2,3-b] [1,4]二氮杂化合物和合成这些化合物的方法。 本发明还涉及含有取代的苯并[f]咪唑并[1,2-d]吡啶并[2,3-b] [1,4]二氮杂化合物的药物组合物和治疗细胞增殖性疾病如癌症的方法， 将这些化合物和药物组合物给予需要的受试者。
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公开(公告)号：US20090136499A1
公开(公告)日：2009-05-28
申请号：US12356097
申请日：2009-01-20
申请人： Jean-Marc Lapierre , Nivedita D. Namdev , Mark A. Ashwell , Dennis S. France , Hui Wu , Patrick M. Hutchins , Manish Tandon , Yanbin Liu , Jeff S. Link , Syed M. Ali , Chris J. Brassard , Robb B. Nicewonger , Anton Filikov , Rebecca J. Carazza
发明人： Jean-Marc Lapierre , Nivedita D. Namdev , Mark A. Ashwell , Dennis S. France , Hui Wu , Patrick M. Hutchins , Manish Tandon , Yanbin Liu , Jeff S. Link , Syed M. Ali , Chris J. Brassard , Robb B. Nicewonger , Anton Filikov , Rebecca J. Carazza
IPC分类号： A61K39/395 , C07D513/04 , A61K31/506 , A61K31/5377 , C07D498/04 , A61P35/00
CPC分类号： C07D513/04
摘要： The present invention provides imidazooxazole and imidazothiazole compounds and their synthesis. The compounds of the present invention are capable of inhibiting the activity of RAF kinase, such as B-RAFV600E. The compounds are useful for the treatment of cell proliferative disorders such as cancer.
摘要翻译： 本发明提供咪唑并恶唑和咪唑并噻唑化合物及其合成。 本发明的化合物能够抑制RAF激酶如B-RAFV600E的活性。 该化合物可用于治疗细胞增殖性疾病如癌症。
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10.发明申请公开(公告)号：US20220269986A1
公开(公告)日：2022-08-25
申请号：US17249177
申请日：2021-02-23
申请人： Anton Filikov
发明人： Anton Filikov
IPC分类号： G06N20/00
摘要： The invention relates to methods of determination of probabilities of events. A probability score is calculated for a data point if the point is classified as “predictable” by a pre-filter model. The score indicates probability of a certain type of event. In addition, methods are disclosed that teach how to build the sub-models and the meta model. The invention discloses a meta model with model-based pre-filtering that takes a set of other (non-meta or meta) “algorithms” and constructs a new algorithm out of those. The meta-model combines other models that predict two different labels: The 1st sub-model learns predictability. The 2nd sub-model is used to filter out “unpredictable” points from new data. The “predictable” part of the data flows into the 3rd sub-model (trained on “predictable” data) that predicts probability score.
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