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公开(公告)号：US08609688B2
公开(公告)日：2013-12-17
申请号：US13529459
申请日：2012-06-21
申请人： Mark A. Ashwell , Chris Brassard , Anton Filikov , Jason Hill , Steffi Koerner , Jean-Marc Lapierre , Yanbin Liu , Nivedita Namdev , Robert Nicewonger , Rocio Palma , Manish Tandon , David Vensel , Akihisa Matsuda , Shin Iimura , Kenichi Yoshida , Takanori Yamazaki , Takahiro Kitamura , Takeshi Isoyama
发明人： Mark A. Ashwell , Chris Brassard , Anton Filikov , Jason Hill , Steffi Koerner , Jean-Marc Lapierre , Yanbin Liu , Nivedita Namdev , Robert Nicewonger , Rocio Palma , Manish Tandon , David Vensel , Akihisa Matsuda , Shin Iimura , Kenichi Yoshida , Takanori Yamazaki , Takahiro Kitamura , Takeshi Isoyama
IPC分类号： A01N43/42 , A61K31/44 , C07D515/02
CPC分类号： C07D471/04 , C07D451/02 , C07D491/08 , C07D498/08
摘要： The present invention relates to substituted imidazopyridinyl-aminopyridine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted imidazopyridinyl-aminopyridine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.
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公开(公告)号：US08501770B2
公开(公告)日：2013-08-06
申请号：US12981127
申请日：2010-12-29
申请人： Mark A. Ashwell , Chris Brassard , Anton Filikov , Jason Hill , Steffi Koerner , Jean-Marc Lapierre , Yanbin Liu , Nivedita Namdev , Robert Nicewonger , Rocio Palma , Manish Tandon , David Vensel , Akihisa Matsuda , Shin Iimura , Yuko Yamamoto
发明人： Mark A. Ashwell , Chris Brassard , Anton Filikov , Jason Hill , Steffi Koerner , Jean-Marc Lapierre , Yanbin Liu , Nivedita Namdev , Robert Nicewonger , Rocio Palma , Manish Tandon , David Vensel , Akihisa Matsuda , Shin Iimura , Yuko Yamamoto
IPC分类号： A01N43/42 , A61K31/44 , C07D471/02 , C07D491/02 , C07D498/02
CPC分类号： C07D471/04
摘要： The present invention relates to substituted imidazopyridinyl-aminopyridine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted imidazopyridinyl-aminopyridine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.
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公开(公告)号：US20080044360A1
公开(公告)日：2008-02-21
申请号：US11618458
申请日：2006-12-29
申请人： Peter Caravan , Andrew Kolodziej , Zhaoda Zhang , Stephane Dumas , Biplab Das , Vincent Jacques , Richard Looby , Steffi Koerner , Wei-Chuan Sun , David Buckler , Aida Abujoub , Aaron Sato
发明人： Peter Caravan , Andrew Kolodziej , Zhaoda Zhang , Stephane Dumas , Biplab Das , Vincent Jacques , Richard Looby , Steffi Koerner , Wei-Chuan Sun , David Buckler , Aida Abujoub , Aaron Sato
CPC分类号： A61B5/055 , A61B5/4519 , A61B5/7289 , A61B5/7292
摘要： Diagnostic compositions and methods for imaging and/or assessing collagen are described. The diagnostic compositions can include collagen binding peptides.
摘要翻译： 描述用于成像和/或评估胶原的诊断组合物和方法。 诊断组合物可以包括胶原结合肽。
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公开(公告)号：US20120108574A1
公开(公告)日：2012-05-03
申请号：US13286294
申请日：2011-11-01
申请人： Mark A. Ashwell , Sudharshan Eathiraj , Anton Filikov , Steffi Koerner , Jean-Marc Lapierre , Yanbin Liu , Rocio Palma , David Vensel , Shin Iimura , Akiko Shiina , Kenichi Yoshida , Takanori Yamazaki , Akihisa Matsuda
发明人： Mark A. Ashwell , Sudharshan Eathiraj , Anton Filikov , Steffi Koerner , Jean-Marc Lapierre , Yanbin Liu , Rocio Palma , David Vensel , Shin Iimura , Akiko Shiina , Kenichi Yoshida , Takanori Yamazaki , Akihisa Matsuda
IPC分类号： A61K31/551 , A61P35/00 , C07D487/14
CPC分类号： C07D471/14 , A61K31/551 , Y02A50/401 , Y02A50/409 , Y02A50/411
摘要： The present invention relates to substituted benzo-imidazo-pyrido-diazepine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted benzo-imidazo-pyrido-diazepine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.
摘要翻译： 本发明涉及取代的苯并咪唑并 - 吡啶并二氮杂化合物及其合成方法。 本发明还涉及含有取代的苯并咪唑并 - 吡啶并二氮杂化合物的药物组合物和通过将这些化合物和药物组合物给予有需要的受试者来治疗细胞增殖性疾病如癌症的方法。
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公开(公告)号：US20110172203A1
公开(公告)日：2011-07-14
申请号：US12981127
申请日：2010-12-29
申请人： Mark A. Ashwell , Chris Brassard , Anton Filikov , Jason Hill , Steffi Koerner , Jean-Marc Lapierre , Yanbin Liu , Nivedita Namdev , Robert Nicewonger , Rocio Palma , Manish Tandon , David Vensel , Akihisa Matsuda , Shin Iimura , Yuko Yamamoto
发明人： Mark A. Ashwell , Chris Brassard , Anton Filikov , Jason Hill , Steffi Koerner , Jean-Marc Lapierre , Yanbin Liu , Nivedita Namdev , Robert Nicewonger , Rocio Palma , Manish Tandon , David Vensel , Akihisa Matsuda , Shin Iimura , Yuko Yamamoto
IPC分类号： A61K31/397 , C07D471/04 , A61K31/437 , C07D401/14 , A61K31/506 , A61K31/497 , C07D413/14 , A61K31/5377 , A61K31/538 , A61K31/553 , A61K31/496 , A61K31/438 , A61P35/00
CPC分类号： C07D471/04
摘要： The present invention relates to substituted imidazopyridinyl-aminopyridine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted imidazopyridinyl-aminopyridine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.
摘要翻译： 本发明涉及取代的咪唑并吡啶基 - 氨基吡啶化合物和合成这些化合物的方法。 本发明还涉及含有取代的咪唑并吡啶基 - 氨基吡啶化合物的药物组合物和通过将这些化合物和药物组合物施用于有需要的受试者来治疗细胞增殖性疾病如癌症的方法。
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![Substituted benzo[f]lmidazo[1,2-d]pyrido[2,3-b][1,4]diazepine compounds](/abs-image/US/2013/10/29/US08569331B2/abs.jpg.150x150.jpg)
6.发明授权Substituted benzo[f]lmidazo[1,2-d]pyrido[2,3-b][1,4]diazepine compounds 有权取代的苯并[f]咪唑并[1,2-d]吡啶并[2,3-b] [1,4]二氮杂化合物公开(公告)号：US08569331B2
公开(公告)日：2013-10-29
申请号：US13286294
申请日：2011-11-01
申请人： Mark A. Ashwell , Sudharshan Eathiraj , Anton Filikov , Steffi Koerner , Jean-Marc Lapierre , Yanbin Liu , Rocio Palma , David Vensel , Shin Iimura , Akiko Shiina , Kenichi Yoshida , Takanori Yamazaki , Akihisa Matsuda
发明人： Mark A. Ashwell , Sudharshan Eathiraj , Anton Filikov , Steffi Koerner , Jean-Marc Lapierre , Yanbin Liu , Rocio Palma , David Vensel , Shin Iimura , Akiko Shiina , Kenichi Yoshida , Takanori Yamazaki , Akihisa Matsuda
IPC分类号： A61K31/44
CPC分类号： C07D471/14 , A61K31/551 , Y02A50/401 , Y02A50/409 , Y02A50/411
摘要： The present invention relates to substituted benzo[f]imidazo[1,2-d]pyrido[2,3-b][1,4]diazepine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted benzo[f]imidazo[1,2-d]pyrido[2,3-b][1,4]diazepine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.
摘要翻译： 本发明涉及取代的苯并[f]咪唑并[1,2-d]吡啶并[2,3-b] [1,4]二氮杂化合物和合成这些化合物的方法。 本发明还涉及含有取代的苯并[f]咪唑并[1,2-d]吡啶并[2,3-b] [1,4]二氮杂化合物的药物组合物和治疗细胞增殖性疾病如癌症的方法， 将这些化合物和药物组合物给予需要的受试者。
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公开(公告)号：US08569282B2
公开(公告)日：2013-10-29
申请号：US12747109
申请日：2008-12-11
申请人： Efrat Ben-Zeev , Dongli Chen , Merav Fichman , Shomir Ghosh , Steffi Koerner , Jian Lin , Yael Marantz , Rosa E. Melendez , Pradyumna Mohanty , Sharon Shacham , Zhaoda Zhang
发明人： Efrat Ben-Zeev , Dongli Chen , Merav Fichman , Shomir Ghosh , Steffi Koerner , Jian Lin , Yael Marantz , Rosa E. Melendez , Pradyumna Mohanty , Sharon Shacham , Zhaoda Zhang
IPC分类号： C07D471/04 , A61K31/4375
CPC分类号： C07D471/04
摘要： Chemokine receptor antagonists, in particular, compounds of Formula (I-A) that act as antagonists of the chemokine CCR2 receptor, including pharmaceutical compositions and uses thereof to treat or prevent diseases associated with monocyte accumulation, lymphocyte accumulation or leukocyte accumulation are described herein.
摘要翻译： 本文描述了趋化因子受体拮抗剂，特别是作为趋化因子CCR2受体的拮抗剂的式（I-A）化合物，包括药物组合物及其用于治疗或预防与单核细胞积聚，淋巴细胞积聚或白细胞积聚相关的疾病的用途。
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公开(公告)号：US20100331298A1
公开(公告)日：2010-12-30
申请号：US12747106
申请日：2008-12-10
申请人： Efrat Ben-Zeev , Dongli Chen , Merav Fichman , Shomir Ghosh , Steffi Koerner , Jian Lin , Yael Marantz , Rosa E. Melendez , Pradyumna Mohanty , Sharon Shacham , Zhaoda Zhang
发明人： Efrat Ben-Zeev , Dongli Chen , Merav Fichman , Shomir Ghosh , Steffi Koerner , Jian Lin , Yael Marantz , Rosa E. Melendez , Pradyumna Mohanty , Sharon Shacham , Zhaoda Zhang
IPC分类号： A61K31/538 , C07D401/06 , C07D405/06 , C07D413/06 , C07D403/06 , C07D417/06 , C07D413/14 , A61K31/4709 , A61K31/453 , A61K31/454 , A61K31/4725 , A61K31/416 , A61K31/423 , A61K31/496 , A61P19/02 , A61P29/00 , A61P17/06 , A61P9/10 , A61P37/06 , A61P3/10 , A61P3/00 , A61P3/04
CPC分类号： C07D401/06 , C07D403/06 , C07D405/06 , C07D413/06 , C07D413/14 , C07D417/06
摘要： Chemokine receptor antagonists, in particular, compounds of Formula (I) that act as antagonists of the chemokine CCR2 receptor, including pharmaceutical compositions and uses thereof to treat or prevent diseases associated with monocyte accumulation, lymphocyte accumulation or leukocyte accumulation are described herein.
摘要翻译： 本文描述了趋化因子受体拮抗剂，特别是作为趋化因子CCR2受体的拮抗剂的式（I）化合物，包括药物组合物及其用于治疗或预防与单核细胞积聚，淋巴细胞积聚或白细胞积聚相关的疾病的用途。
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公开(公告)号：US20100324035A1
公开(公告)日：2010-12-23
申请号：US12747109
申请日：2008-12-11
申请人： Efrat Ben-Zeev , Dongli Chenl , Merav Fichman , Shomir Ghosh , Steffi Koerner , Jian Lin , Yael Marantz , Rosa E. Melendez , Pradyumma Mohanty , Sharon Shacham , Zhaoda Zhang
发明人： Efrat Ben-Zeev , Dongli Chenl , Merav Fichman , Shomir Ghosh , Steffi Koerner , Jian Lin , Yael Marantz , Rosa E. Melendez , Pradyumma Mohanty , Sharon Shacham , Zhaoda Zhang
IPC分类号： A61K31/538 , A61K31/501 , A61K31/4375 , C07D471/02
CPC分类号： C07D471/04
摘要： Chemokine receptor antagonists, in particular, compounds of Formula (I-A) that act as antagonists of the chemokine CCR2 receptor, including pharmaceutical compositions and uses thereof to treat or prevent diseases associated with monocyte accumulation, lymphocyte accumulation or leukocyte accumulation are described herein.
摘要翻译： 本文描述了趋化因子受体拮抗剂，特别是作为趋化因子CCR2受体的拮抗剂的式（I-A）化合物，包括药物组合物及其用于治疗或预防与单核细胞积聚，淋巴细胞积聚或白细胞积聚相关的疾病的用途。
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公开(公告)号：US20100210633A1
公开(公告)日：2010-08-19
申请号：US12445134
申请日：2007-10-12
申请人： Jian Lin , Dongli Chen , Steffi Koerner , Rosa E. Melendez , Pradyumma Mohanty , Efrat Ben-Zeev , Merav Fichman , Yael Marantz , Oren Becker , Dilara McCauley , Pini Orbach , Ashis K. Saha , Sharon Shacham , Michael Xie
发明人： Jian Lin , Dongli Chen , Steffi Koerner , Rosa E. Melendez , Pradyumma Mohanty , Efrat Ben-Zeev , Merav Fichman , Yael Marantz , Oren Becker , Dilara McCauley , Pini Orbach , Ashis K. Saha , Sharon Shacham , Michael Xie
IPC分类号： A61K31/541 , C07D405/06 , A61K31/453 , A61P3/10 , A61P3/04 , A61P37/06 , A61P17/06 , A61P9/10 , A61P13/12 , A61P1/16 , C07D211/62 , A61K31/445 , C07D207/16 , A61K31/40 , A61K31/4525 , C07D413/10 , A61K31/454 , C07D405/14 , A61K31/496 , C07D401/06 , A61K31/4545 , C07D401/04 , C07D417/06 , C07D413/06 , A61K31/5377
CPC分类号： C07D405/06 , C07D207/08 , C07D207/16 , C07D211/62 , C07D401/04 , C07D401/06 , C07D401/10 , C07D405/14 , C07D407/06 , C07D409/14 , C07D411/14 , C07D413/06 , C07D413/10 , C07D417/06 , C07D417/14
摘要： Chemokine receptor antagonists, in particular, compounds of Formula (I) that act as antagonists of the chemokine CCR2 receptor, including pharmaceutical compositions and uses thereof to treat or prevent diseases associated with monocyte accumulation, lymphocyte accumulation or leukocyte accumulation are described herein.
摘要翻译： 本文描述了趋化因子受体拮抗剂，特别是作为趋化因子CCR2受体的拮抗剂的式（I）化合物，包括药物组合物及其用于治疗或预防与单核细胞积聚，淋巴细胞积聚或白细胞积聚相关的疾病的用途。
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