公开(公告)号：USRE44173E1

公开(公告)日：2013-04-23

申请号：US13171272

申请日：2011-06-28

申请人： John R. Noll ,  Christopher J. Peters ,  Jeffrey W. Smith ,  Terry L. Williams

发明人： John R. Noll ,  Christopher J. Peters ,  Jeffrey W. Smith ,  Terry L. Williams

IPC分类号： H04Q7/20

CPC分类号： H04W16/28 ,  H04B7/2606 ,  H04W16/26 ,  H04W72/046 ,  H04W72/082

摘要： A spectrally efficient wireless communication system that includes a plurality of base stations communicating indirectly with a plurality of wireless communications devices through a plurality of repeaters. The method can generally comprise communicating indirectly between a first base station and a wireless communication device using a first repeater and a first RF backhaul link. A control processor associated with the first base station can control a first smart antenna system. The system selectively configures the first smart antenna system to spatially isolate communications on the first RF backhaul from communications on a second RF backhaul of a second repeater.

公开(公告)号：USRE42605E1

公开(公告)日：2011-08-09

申请号：US12191866

申请日：2008-08-14

申请人： John R. Noll ,  Christopher J. Peters ,  Jeffrey W. Smith ,  Terry L. Williams

发明人： John R. Noll ,  Christopher J. Peters ,  Jeffrey W. Smith ,  Terry L. Williams

IPC分类号： H04Q7/20

CPC分类号： H04W16/28 ,  H04B7/2606 ,  H04W16/26 ,  H04W72/046 ,  H04W72/082

摘要： A spectrally efficient wireless communication system that includes a plurality of base stations communicating indirectly with a plurality of wireless communications devices through a plurality of repeaters. The method can generally comprise communicating indirectly between a first base station and a wireless communication device using a first repeater and a first RF backhaul link. A control processor associated with the first base station can control a first smart antenna system. The system selectively configures the first smart antenna system to spatially isolate communications on the first RF backhaul from communications on a second RF backhaul of a second repeater.

摘要翻译： 一种频谱有效的无线通信系统，其包括通过多个中继器间接与多个无线通信设备通信的多个基站。 该方法通常可以包括使用第一中继器和第一RF回程链路在第一基站和无线通信设备之间间接通信。 与第一基站相关联的控制处理器可以控制第一智能天线系统。 系统选择性地配置第一智能天线系统以将第一RF回程上的通信与第二中继器的第二RF回程上的通信空间隔离。

公开(公告)号：US07092714B2

公开(公告)日：2006-08-15

申请号：US10074514

申请日：2002-02-12

申请人： John R. Noll ,  Christopher J. Peters ,  Jeffrey W. Smith ,  Terry L. Williams

发明人： John R. Noll ,  Christopher J. Peters ,  Jeffrey W. Smith ,  Terry L. Williams

IPC分类号： H04Q7/20

CPC分类号： H04W16/28 ,  H04B7/2606 ,  H04W16/26 ,  H04W72/046 ,  H04W72/082

摘要： A spectrally efficient wireless communication system that includes a plurality of base stations communicating indirectly with a plurality of wireless communications devices through a plurality of repeaters. The method can generally comprise communicating indirectly between a first base station and a wireless communication device using a first repeater and a first RF backhaul link. A control processor associated with the first base station can control a first smart antenna system. The system selectively configures the first smart antenna system to spatially isolate communications on the first RF backhaul from communications on a second RF backhaul of a second repeater.

公开(公告)号：US08712475B2

公开(公告)日：2014-04-29

申请号：US13350489

申请日：2012-01-13

申请人： John R. Noll ,  Jeffrey W. Smith ,  Shannon Tomarchio ,  Brady Gaughan

发明人： John R. Noll ,  Jeffrey W. Smith ,  Shannon Tomarchio ,  Brady Gaughan

IPC分类号： H04B1/38

CPC分类号： H04B7/0848 ,  H04B17/21

摘要： A base transceiver station including a transceiver unit is provided. A method of calibration uses a transceiver unit to receive an RF signal, measure a calibration value, and transmit the measured value. The calibration value is used to determine weighting parameters to compensate for relative RF path phase delay and amplitude variation.

摘要翻译： 提供了包括收发器单元的基站收发器。 校准方法使用收发器单元来接收RF信号，测量校准值并传输测量值。 校准值用于确定加权参数以补偿相对RF路径相位延迟和幅度变化。

公开(公告)号：US20100069120A1

公开(公告)日：2010-03-18

申请号：US12622956

申请日：2009-11-20

申请人： John R. Noll ,  Jeffrey W. Smith ,  Shannon Tomarchio ,  Brady Gaughan

发明人： John R. Noll ,  Jeffrey W. Smith ,  Shannon Tomarchio ,  Brady Gaughan

IPC分类号： H04B1/38 ,  H04B1/713

CPC分类号： H04B7/0848 ,  H04B17/21

摘要： A method for calibration of RF paths of a frequency hopping adaptive base transceiver station is provided. The method of calibration calibrates a wireless cellular telecommunication system with a frequency hopping adaptive base transceiver station including an adaptive antenna array with two or more RF traffic transceiver apparatus chains. The wireless cellular telecommunication system communicates with mobile units on a frequencies defined by a hop list. The method of calibration includes the step of periodically interrupting a frequency hopping process of the frequency hopping adaptive base transceiver station while calls are in progress. The method of calibration further includes the step of calibrating an antenna transmit path for a RF traffic transceiver apparatus chain at a frequency selected to include one or more frequencies in the hop list to determine a set of weighting parameters for the antenna transmit path at the one or more frequencies. A self-calibrating frequency hopping adaptive base transceiver station is also provided.

摘要翻译： 提供了一种用于校准跳频自适应基站的射频路径的方法。 校准方法使用包括具有两个或更多个RF业务收发器设备链的自适应天线阵列的跳频自适应基站收发器校准无线蜂窝电信系统。 无线蜂窝电信系统在跳频列表定义的频率上与移动单元进行通信。 校准方法包括在呼叫进行期间周期性地中断跳频自适应基站收发机的跳频过程的步骤。 校准方法还包括校准用于RF业务收发器设备链的天线发射路径的步骤，该频率被选择为包括跳频列表中的一个或多个频率，以确定一个天线发射路径的一组加权参数 或更多的频率。 还提供了自校准跳频自适应基站收发台。

公开(公告)号：US08116817B2

公开(公告)日：2012-02-14

申请号：US12622956

申请日：2009-11-20

申请人： John R. Noll ,  Jeffrey W. Smith ,  Shannon Tomarchio ,  Brady Gaughan

发明人： John R. Noll ,  Jeffrey W. Smith ,  Shannon Tomarchio ,  Brady Gaughan

IPC分类号： H04B1/38

CPC分类号： H04B7/0848 ,  H04B17/21

摘要： A method for calibration of RF paths of a frequency hopping adaptive base transceiver station is provided. The method of calibration calibrates a wireless cellular telecommunication system with a frequency hopping adaptive base transceiver station including an adaptive antenna array with two or more RF traffic transceiver apparatus chains. The wireless cellular telecommunication system communicates with mobile units on a frequencies defined by a hop list. The method of calibration includes the step of periodically interrupting a frequency hopping process of the frequency hopping adaptive base transceiver station while calls are in progress. The method of calibration further includes the step of calibrating an antenna transmit path for a RF traffic transceiver apparatus chain at a frequency selected to include one or more frequencies in the hop list to determine a set of weighting parameters for the antenna transmit path at the one or more frequencies. A self-calibrating frequency hopping adaptive base transceiver station is also provided.

摘要翻译： 提供了一种用于校准跳频自适应基站的射频路径的方法。 校准方法使用包括具有两个或更多个RF业务收发器设备链的自适应天线阵列的跳频自适应基站收发器校准无线蜂窝电信系统。 无线蜂窝电信系统在跳频列表定义的频率上与移动单元进行通信。 校准方法包括在呼叫进行期间周期性地中断跳频自适应基站收发机的跳频过程的步骤。 校准方法还包括校准用于RF业务收发器设备链的天线发射路径的步骤，该频率被选择为包括跳频列表中的一个或多个频率，以确定一个天线发射路径的一组加权参数 或更多的频率。 还提供了自校准跳频自适应基站收发台。

公开(公告)号：US20120178437A1

公开(公告)日：2012-07-12

申请号：US13350489

申请日：2012-01-13

申请人： John R. Noll ,  Jeffrey W. Smith ,  Shannon Tomarchio ,  Brady Gaughan

发明人： John R. Noll ,  Jeffrey W. Smith ,  Shannon Tomarchio ,  Brady Gaughan

IPC分类号： H04W4/00

CPC分类号： H04B7/0848 ,  H04B17/21

摘要： A base transceiver station including a transceiver unit is provided. A method of calibration uses a transceiver unit to receive an RF signal, measure a calibration value, and transmit the measured value. The calibration value is used to determine weighting parameters to compensate for relative RF path phase delay and amplitude variation.

摘要翻译： 提供了包括收发器单元的基站收发器。 校准方法使用收发器单元来接收RF信号，测量校准值并传输测量值。 校准值用于确定加权参数以补偿相对RF路径相位延迟和幅度变化。

公开(公告)号：US08563248B2

公开(公告)日：2013-10-22

申请号：US12959349

申请日：2010-12-02

申请人： Jeffrey W. Smith ,  Changming Fang

发明人： Jeffrey W. Smith ,  Changming Fang

IPC分类号： C07H21/04 ,  C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/106

摘要： We have identified a new variant of ileal bile acid binding protein (IBABP), designated IBABP-L, which is a biomarker for colorectal cancer. The transcript for IBABP-L arises from an alternative start site and includes three exons that are absent in IBABP. IBABP-L also shares part of a fourth exon with IBABP. The protein encoded by IBABP-L contains a deduced 49 residue N-terminal sequence that is not found in the IBABP protein. The present invention provides methods for diagnosing colorectal cancer and other compositions and methods based on this discovery.

摘要翻译： 我们已经确定了回肠胆汁酸结合蛋白（IBABP）的新变体，称为IBABP-L，其是结肠直肠癌的生物标志物。 IBABP-L的成绩单来自替代起始位点，并且包括IBABP中缺少的三个外显子。 IBABP-L还与IBABP共享第四外显子的一部分。 由IBABP-L编码的蛋白质含有在IBABP蛋白中未发现的49个残基的N-末端序列。 本发明提供了用于诊断结肠直肠癌的方法以及基于该发现的其它组合物和方法。

公开(公告)号：US08119653B2

公开(公告)日：2012-02-21

申请号：US11775154

申请日：2007-07-09

申请人： Daniel Romo ,  Sung Wook Cho ,  Jeffrey W. Smith ,  Robyn D. Richardson

发明人： Daniel Romo ,  Sung Wook Cho ,  Jeffrey W. Smith ,  Robyn D. Richardson

IPC分类号： A61K31/436 ,  C07D221/18

CPC分类号： C07D407/12 ,  C07D305/12

摘要： Derivatives of belactosin and their synthesis are disclosed. In certain embodiments, compounds of the present invention exhibit anti-cancer, antiviral, antibiotic, and/or auto-immune therapeutic abilities. In general, methods of synthesis disclosed herein allow for introduction of a variety of substituents at numerous positions as well as the facile introduction of a beta-lactone ring moiety. The synthetic steps comprise, in preferred embodiments, a tandem Mukaiyama aldol lactonization reaction. Data demonstrating the utility of some of the derivatives as proteasome inhibitors is also disclosed.

摘要翻译： 披露了双乳糖蛋白衍生物及其合成。 在某些实施方案中，本发明的化合物表现出抗癌，抗病毒，抗生素和/或自身免疫治疗能力。 通常，本文公开的合成方法允许在多个位置引入各种取代基以及容易地引入β-内酯环部分。 在优选实施方案中，合成步骤包括串联的Mukaiyama醛醇内酯反应。 还公开了证明一些衍生物作为蛋白酶体抑制剂的效用的数据。

公开(公告)号：US07799826B2

公开(公告)日：2010-09-21

申请号：US10418513

申请日：2003-04-16

申请人： Jeffrey W. Smith ,  Fumiko Axelrod ,  Steven J. Kridel

发明人： Jeffrey W. Smith ,  Fumiko Axelrod ,  Steven J. Kridel

IPC分类号： A61K31/335

CPC分类号： A61K31/337 ,  A61K31/335 ,  A61K31/336 ,  A61K31/365 ,  A61K31/40 ,  A61K31/42 ,  A61K31/425 ,  A61K31/445 ,  A61K31/585 ,  G01N33/5011 ,  G01N2333/91057

摘要： The present invention features methods of treating a cancer in a subject by administering an effective amount of a beta-lactone to the subject. The invention also features methods of inhibiting angiogenesis in a subject by administering an effective amount of an inhibitor of fatty acid synthase to the subject. These methods can be used to treat a variety of cancers and other diseases and conditions. The invention also features methods of identifying beta-lactones and other compounds that can be used in the methods of the invention for the treatment of tumors, inhibition of angiogenesis, and the treatment of diseases and conditions that involve pathological angiogenesis.

摘要翻译： 本发明的特征在于通过向受试者施用有效量的β-内酯来治疗受试者的癌症的方法。 本发明还具有通过向受试者施用有效量的脂肪酸合酶抑制剂来抑制受试者血管生成的方法。 这些方法可用于治疗各种癌症和其他疾病和病症。 本发明还涉及鉴定可用于本发明治疗肿瘤，抑制血管发生以及涉及病理性血管生成的疾病和病症的治疗的β-内酯和其它化合物的方法。