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1.
公开(公告)号:US4575495A
公开(公告)日:1986-03-11
申请号:US631661
申请日:1984-07-17
申请人: John Vnek , Alfred M. Prince , Hafeez Ikram
发明人: John Vnek , Alfred M. Prince , Hafeez Ikram
CPC分类号: C07K14/005 , A61K39/00 , C12N2730/10122 , Y10S930/223
摘要: There is disclosed a new synthetic peptide which evokes an immunological response. The synthetic peptide, moreover, interacts with antibodies to Hepatitis B surface antigen (HBsAG). Thus, the synthetic peptide is useful as an immunizing agent in a vaccine as an active component thereof where it serves to produce antibodies in vivo which are protective against Hepatitis B virus. The synthetic peptide of the invention comprises the following sequence of amino acids: Arg Trp Met Met Leu Arg Arg(I) and preferably has the following sequence: Gly Tyr Arg Trp Met Met Leu Arg Arg Phe Gly (II).
摘要翻译: 公开了一种引起免疫应答的新型合成肽。 此外,合成肽与乙型肝炎表面抗原(HBsAG)的抗体相互作用。 因此,合成肽可用作疫苗中的免疫剂作为其活性成分,其用于在体内产生抗乙型肝炎病毒的抗体。 本发明的合成肽包含以下氨基酸序列:Arg Trp Met Met Leu Arg Arg(I),优选具有以下序列:Gly Tyr Arg Trp Met Met Leu Arg Arg Phe Gly(II)。
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2.
公开(公告)号:US4578217A
公开(公告)日:1986-03-25
申请号:US493904
申请日:1983-05-12
申请人: John Vnek , Alfred M. Prince , Hafeez Ikram
发明人: John Vnek , Alfred M. Prince , Hafeez Ikram
IPC分类号: A61K39/00 , C07K14/02 , C07K14/075 , A61K37/00
CPC分类号: C07K14/005 , A61K39/00 , C12N2730/10122 , Y10S530/806 , Y10S930/223
摘要: There is disclosed a new synthetic peptide which evokes an immunological response. The synthetic peptide, moreover, interacts with antibodies to hepatitis B surface antigen (HBsAg). Thus, the synthetic peptide is useful as an immunizing agent in a vaccine as an active component thereof where it serves to produce antibodies in vivo which are protective against hepatitis B virus. The synthetic peptide of the invention comprises the following sequence of amino acids: Arg Trp Met Met Leu Arg Arg (I) and preferably has the following sequence: Gly Tyr Arg Trp Met Met Leu Arg Arg Phe Gly (II).
摘要翻译: 公开了一种引起免疫应答的新型合成肽。 此外,合成肽与乙型肝炎表面抗原(HBsAg)的抗体相互作用。 因此,合成肽可用作疫苗中的免疫剂作为其活性成分,其用于在体内产生抗乙型肝炎病毒的抗体。 本发明的合成肽包含以下氨基酸序列:Arg Trp Met Met Leu Arg Arg(I),优选具有以下序列:Gly Tyr Arg Trp Met Met Leu Arg Arg Phe Gly(II)。
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