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    Synthetic antigenic peptide derived from Hepatitis B surface antigen
    1.
    发明授权
    Synthetic antigenic peptide derived from Hepatitis B surface antigen 失效
    衍生自乙型肝炎表面抗原的合成抗原肽

    公开(公告)号：US4575495A

    公开(公告)日：1986-03-11

    申请号：US631661

    申请日：1984-07-17

    申请人： John Vnek ,  Alfred M. Prince ,  Hafeez Ikram

    发明人： John Vnek ,  Alfred M. Prince ,  Hafeez Ikram

    IPC分类号： A61K39/00 ,  C07K14/02 ,  A61K37/00

    CPC分类号： C07K14/005 ,  A61K39/00 ,  C12N2730/10122 ,  Y10S930/223

    摘要： There is disclosed a new synthetic peptide which evokes an immunological response. The synthetic peptide, moreover, interacts with antibodies to Hepatitis B surface antigen (HBsAG). Thus, the synthetic peptide is useful as an immunizing agent in a vaccine as an active component thereof where it serves to produce antibodies in vivo which are protective against Hepatitis B virus. The synthetic peptide of the invention comprises the following sequence of amino acids: Arg Trp Met Met Leu Arg Arg(I) and preferably has the following sequence: Gly Tyr Arg Trp Met Met Leu Arg Arg Phe Gly (II).

    摘要翻译： 公开了一种引起免疫应答的新型合成肽。 此外，合成肽与乙型肝炎表面抗原（HBsAG）的抗体相互作用。 因此，合成肽可用作疫苗中的免疫剂作为其活性成分，其用于在体内产生抗乙型肝炎病毒的抗体。 本发明的合成肽包含以下氨基酸序列：Arg Trp Met Met Leu Arg Arg（I），优选具有以下序列：Gly Tyr Arg Trp Met Met Leu Arg Arg Phe Gly（II）。

    Synthetic antigenic peptide derived from hepatitis B surface antigen
    3.
    发明授权
    Synthetic antigenic peptide derived from hepatitis B surface antigen 失效
    衍生自乙型肝炎表面抗原的合成抗原肽

    公开(公告)号：US4578217A

    公开(公告)日：1986-03-25

    申请号：US493904

    申请日：1983-05-12

    申请人： John Vnek ,  Alfred M. Prince ,  Hafeez Ikram

    发明人： John Vnek ,  Alfred M. Prince ,  Hafeez Ikram

    IPC分类号： A61K39/00 ,  C07K14/02 ,  C07K14/075 ,  A61K37/00

    CPC分类号： C07K14/005 ,  A61K39/00 ,  C12N2730/10122 ,  Y10S530/806 ,  Y10S930/223

    摘要： There is disclosed a new synthetic peptide which evokes an immunological response. The synthetic peptide, moreover, interacts with antibodies to hepatitis B surface antigen (HBsAg). Thus, the synthetic peptide is useful as an immunizing agent in a vaccine as an active component thereof where it serves to produce antibodies in vivo which are protective against hepatitis B virus. The synthetic peptide of the invention comprises the following sequence of amino acids: Arg Trp Met Met Leu Arg Arg (I) and preferably has the following sequence: Gly Tyr Arg Trp Met Met Leu Arg Arg Phe Gly (II).

    摘要翻译： 公开了一种引起免疫应答的新型合成肽。 此外，合成肽与乙型肝炎表面抗原（HBsAg）的抗体相互作用。 因此，合成肽可用作疫苗中的免疫剂作为其活性成分，其用于在体内产生抗乙型肝炎病毒的抗体。 本发明的合成肽包含以下氨基酸序列：Arg Trp Met Met Leu Arg Arg（I），优选具有以下序列：Gly Tyr Arg Trp Met Met Leu Arg Arg Phe Gly（II）。

    Large scale purification of hepatitis type B antigen using polyethylene glycol
    7.
    发明授权
    Large scale purification of hepatitis type B antigen using polyethylene glycol 失效
    使用聚乙二醇大规模纯化乙型肝炎抗原

    公开(公告)号：US3951937A

    公开(公告)日：1976-04-20

    申请号：US426825

    申请日：1973-12-20

    申请人： John Vnek ,  Alfred M. Prince

    发明人： John Vnek ,  Alfred M. Prince

    IPC分类号： C07K14/02 ,  C07G7/00

    CPC分类号： C07K14/005 ,  C12N2730/10122 ,  Y10S435/803 ,  Y10S530/806 ,  Y10S530/83

    摘要： Highly purified type B hepatitis antigen (HB Ag) is produced from fluid blood material containing such antigen by subjecting blood material containing naturally occurring HB Ag to a double precipitation with polyethylene glycol. In each precipitation, the pH of the fluid blood material is maintained at approximately 4.4 to 4.7 and a polyethylene glycol concentration of approximately 4.0 to 4.5 weight per cent is used. Particularly good results are obtained if the temperature of the material is maintained in the range of 0.degree. to 8.degree.C after the polyethylene glycol has been added. The antigen thus obtained may be further purified by absorption of impurities to hydroxy apatite, followed by isopycnic banding and zonal ultracentrifugation. Hydroxy apatite column chromatography is used to separate the purified antigen into three separate populations of particles.

    摘要翻译： 通过使含有天然存在的HB Ag的血液物质与聚乙二醇进行双重沉淀，由含有该抗原的流体血液物质制备高纯度乙型肝炎抗原（HB Ag）。 在每次沉淀中，流体血液物质的pH保持在约4.4至4.7，并且使用约4.0至4.5重量％的聚乙二醇浓度。 在加入聚乙二醇后，如果材料的温度保持在0〜8℃的范围内，则可获得特别好的结果。 由此获得的抗原可以通过将杂质吸收到羟磷灰石中进一步纯化，随后进行等环条带和带状超速离心。 羟磷灰石柱色谱用于将纯化的抗原分离成三个分开的颗粒群。