公开(公告)号：US5395393A

公开(公告)日：1995-03-07

申请号：US901644

申请日：1992-06-22

申请人： John Wickham

发明人： John Wickham

IPC分类号： A61N1/365 ,  A61N1/39 ,  A61N1/36 ,  A61N1/362 ,  A61N1/368

CPC分类号： A61N1/3962 ,  A61N1/365

摘要： An implantable cardioverter/defibrillator device having an improved sensing system for automatically and rapidly adjusting to changing amplitudes of intracardiac electrogram "ICEG" signals during transitions between normal sinus rhythm and ventricular tachycardia/ventricular fibrillation of a patient's heart is disclosed. ICEG signals are sensed, amplified and filtered to remove high frequency and low frequency noise and artifacts therefrom. Crossings of positive and negative threshold levels by the filtered signals are detected and corresponding positive and negative output signals representative thereof are provided. The positive and negative threshold levels are varied in accordance with corresponding variations of fractions of the levels of the filtered signals so that the positive and negative threshold levels move independently of one another in response to changes in the levels of the filtered signals; and, the positive and negative output signals generated during each heart beat are rationalized so that only one output signal is provided per heart beat.

摘要翻译： 公开了具有改进的感测系统的植入式心律转复器/除颤器装置，用于在患者心脏的正常窦性心律和室性心动过速/心室颤动之间的过渡期间自动且快速地调节心内电描记图“ICEG”信号的变化幅度。 ICEG信号被感测，放大和滤波以去除高频和低频噪声及其伪影。 检测由滤波后的信号产生的正和负阈值电平的交叉，并提供相应的表示其的正，负输出信号。 正和负阈值电平根据滤波信号的电平的分数的相应变化而变化，使得正和负阈值电平响应于滤波信号的电平的变化而彼此独立地移动; 并且在每个心跳期间产生的正和负输出信号被合理化，使得每个心跳仅提供一个输出信号。

公开(公告)号：US5492128A

公开(公告)日：1996-02-20

申请号：US328695

申请日：1994-10-25

申请人： John Wickham

发明人： John Wickham

IPC分类号： A61N1/365 ,  A61N1/39 ,  A61B5/04

CPC分类号： A61N1/3962 ,  A61N1/365

摘要： An implantable cardioverter/defibrillator device having an improved sensing system for automatically and rapidly adjusting to changing amplitudes of intracardiac electrogram "ICEG" signals during transitions between normal sinus rhythm and ventricular tachycardia/ventricular fibrillation of a patient's heart is disclosed. ICEG signals are sensed, amplified and filtered to remove high frequency and low frequency noise and artifacts therefrom. Crossings of positive and negative threshold levels by the filtered signals are detected and corresponding positive and negative output signals representative thereof are provided. The positive and negative threshold levels are varied in accordance with corresponding variations of fractions of the levels of the filtered signals so that the positive and negative threshold levels move independently of one another in response to changes in the levels of the filtered signals; and, the positive and negative output signals generated during each heart beat are rationalized so that only one output signal is provided per heart beat.

公开(公告)号：US5400795A

公开(公告)日：1995-03-28

申请号：US141805

申请日：1993-10-22

申请人： Anthony J. Murphy ,  John Wickham ,  David Bassin

发明人： Anthony J. Murphy ,  John Wickham ,  David Bassin

IPC分类号： A61B5/0452 ,  A61N1/39 ,  G06F17/00 ,  A61B5/0472

CPC分类号： A61N1/3956 ,  A61B5/04525 ,  A61B5/7264 ,  Y10S128/925

摘要： A method, useable in implantable cardioverter defibrillators, for classifying heart rhythms of a patient by means of electrogram morphology. A number of features (metrics) of the electrogram are measured to form a description of the shape of individual electrograms, and the metrics are then converted into a cardiac rhythm diagnosis by means of a pattern classification technique.

摘要翻译： 一种可用于植入式心律转复除颤器的方法，用于通过电描记图形态分类患者的心律。 测量电描记图的多个特征（度量）以形成各个电描记图的形状的描述，然后通过图案分类技术将度量转换成心律。

公开(公告)号：US5897575A

公开(公告)日：1999-04-27

申请号：US957336

申请日：1997-10-24

申请人： John Wickham

发明人： John Wickham

IPC分类号： A61N1/362 ,  A61N1/39 ,  A61N1/36

CPC分类号： A61N1/3621 ,  A61N1/3956

摘要： An implantable cardiac device wherein a reliability indicator is developed for cardiac classification based on the presence or absence of noise. If the classification is unreliable a robust therapy is applied until the cardiac condition is confirmed.

摘要翻译： 一种可植入心脏装置，其中基于噪声的存在或不存在，开发用于心脏分类的可靠性指示符。 如果分类不可靠，则应用强直的治疗直到心脏病状得到证实。

公开(公告)号：US5891171A

公开(公告)日：1999-04-06

申请号：US955540

申请日：1997-10-22

申请人： John Wickham

发明人： John Wickham

IPC分类号： A61N1/362 ,  A61N1/39

CPC分类号： A61B5/042 ,  A61B5/0428 ,  A61B5/0472 ,  A61B5/7203 ,  A61B5/7217 ,  A61N1/3622 ,  A61N1/3962 ,  Y10S128/901

摘要： An implantable cardiac device includes electrodes for sensing and pacing the heart, and optionally, defibrillation electrodes. The IECG with a noise component sensed in the heart is processed to derive raw sense signals indicative of whether the sensed QRS complexe's range is outside a certain range. This range is dynamically adjusted to compensate for the noise component. Preferably this range is defined by a threshold signal generator which generates a threshold signal including a first part which varies dynamically in accordance with a preset criteria and a second part which is at least equal to the peak amplitude of the noise.

摘要翻译： 可植入心脏装置包括用于感测和起搏心脏的电极，以及任选的除颤电极。 处理在心脏中感测到的噪声分量的IECG以得到指示所感测到的QRS复杂度范围是否在一定范围之外的原始感测信号。 该范围被动态调整以补偿噪声分量。 优选地，该范围由阈值信号发生器定义，阈值信号发生器产生包括根据预设标准动态变化的第一部分和至少等于噪声峰值振幅的第二部分的阈值信号。

公开(公告)号：US20060005405A1

公开(公告)日：2006-01-12

申请号：US10953426

申请日：2004-09-29

申请人： John Wickham ,  James Brun ,  Robert Paquin

发明人： John Wickham ,  James Brun ,  Robert Paquin

IPC分类号： G01B3/14

CPC分类号： G01B3/48

摘要： A device for confirming the presence of thread in nuts and other threaded parts has a threaded gage mounted on a holder which is connected through a clutch to a motor. The motor drives the holder to rotate the threaded gage to engage the threaded part. Switches are provided to stop and reverse the motor. The device identifies parts without threads and also damaged and incomplete threads. The device does not impart undue force levels to unthreaded, undersized parts or defective parts. The device confirms threads in threaded blind bores.

公开(公告)号：US5251626A

公开(公告)日：1993-10-12

申请号：US918934

申请日：1992-07-22

申请人： Peter Nickolls ,  Geoff Drane ,  Barry Flower ,  Paul Lunsmann ,  Robert Dodd ,  David Bassin ,  John Wickham ,  Tony Murphy

发明人： Peter Nickolls ,  Geoff Drane ,  Barry Flower ,  Paul Lunsmann ,  Robert Dodd ,  David Bassin ,  John Wickham ,  Tony Murphy

IPC分类号： A61N1/365 ,  A61N1/39

CPC分类号： A61N1/36514 ,  A61N1/3962 ,  Y10S128/925

摘要： An apparatus and method for the detection and treatment of arrhythmias using a processor having a neural network with a hierarchical arrangement including a first lower level for classifying individual waveforms, a second higher level for diagnosing detected arrhythmias and a third higher level for the application of therapy in response to a diagnosed arrhythmia. The neural network may be a back propogation neural network or an associative memory type neural network. The arrhythmias detected may be at least one of bradycardia, tachycardia and fibrillation. The apparatus may include a cardioverting/defibrillating pacemaker. In general, the apparatus acquires physiological signals representative of heart activity in a patient. A neural network receives the physiological signals and determines if any arrhythmia is present, and if present, selects therapy to be applied to the heart. A therapy generator then applies the therapy selected by the neural network. The physiological signals may be processed or unprocessed ECG signal, signals indicative of the properties of the blood including the presence of gases, blood temperature, and blood flow signals or signals representative of ventricular wall impedance or ventricular volume.

摘要翻译： 一种用于使用具有具有分层布置的神经网络的处理器来检测和治疗心律失常的装置和方法，所述分层布置包括用于分类各个波形的第一较低级别，用于诊断检测到的心律失常的第二较高级别和用于治疗的第三更高级别 响应于诊断的心律失常。 神经网络可以是反向传播神经网络或关联记忆型神经网络。 检测到的心律失常可能是心动过缓，心动过速和原纤维化之中的至少一种。 该装置可以包括心脏复律/除颤起搏器。 通常，该装置获取代表患者心脏活动的生理信号。 神经网络接收生理信号并确定是否存在心律不齐，如果存在，则选择应用于心脏的治疗。 然后治疗发生器应用由神经网络选择的治疗。 生理信号可以被处理或未处理的ECG信号，指示血液性质的信号，包括气体的存在，血液温度和血流信号或表示心室壁阻抗或心室容积的信号。