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    Protection of female reproductive system from natural and artifical insults
    1.
    发明申请
    Protection of female reproductive system from natural and artifical insults 审中-公开
    保护女性生殖系统免受自然和人为侮辱

    公开(公告)号：US20070157331A1

    公开(公告)日：2007-07-05

    申请号：US11715795

    申请日：2007-03-07

    申请人： Johnathan Tilly ,  Richard Kolesnick

    发明人： Johnathan Tilly ,  Richard Kolesnick

    IPC分类号： A01K67/027

    CPC分类号： A61K31/66 ,  A61K31/00 ,  A61K31/661 ,  A61K31/685 ,  A61K31/688

    摘要： Described are methods for protecting the female reproductive system against natural and artificial insults by administering to women a composition comprising an agent that antagonizes one or more acid sphingomyelinase (ASMase) gene products. Specifically, methods disclosed herein serve to protect women's germline from damage resulting from cancer therapy regimens including chemotherapy or radiotherapy. In one aspect, the method preserves, enhances, or revives ovarian function in women, by administering to women a composition containing sphingosine-1-phosphate, or an analog thereof. Also disclosed are methods to prevent or ameliorate menopausal syndromes and to improve in vitro fertilization techniques.

    摘要翻译： 描述了通过向妇女施用包含拮抗一种或多种酸性鞘磷脂酶（ASMase）基因产物的组合物的组合物来保护雌性生殖系统免受天然和人造侮辱的方法。 具体来说，本文公开的方法用于保护妇女的种系免受包括化学疗法或放射治疗在内的癌症治疗方案的损害。 在一个方面，通过向妇女施用含有鞘氨醇-1-磷酸或其类似物的组合物，该方法保留，增强或恢复妇女的卵巢功能。 还公开了预防或改善绝经综合征和改善体外受精技术的方法。

    Kinase supressor of Ras inactivation for therapy of Ras mediated tumorigenesis
    2.
    发明申请
    Kinase supressor of Ras inactivation for therapy of Ras mediated tumorigenesis 失效
    Ras灭活激酶抑制剂治疗Ras介导的肿瘤发生

    公开(公告)号：US20080096840A1

    公开(公告)日：2008-04-24

    申请号：US11974473

    申请日：2007-10-12

    申请人： Richard Kolesnick ,  Hongmei Xing

    发明人： Richard Kolesnick ,  Hongmei Xing

    IPC分类号： A61K31/70 ,  A61P43/00 ,  C12N5/06

    CPC分类号： C12N15/8509 ,  A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0331 ,  A61K38/00 ,  C12N15/113 ,  C12N15/1137 ,  C12N2310/11 ,  C12N2310/111 ,  C12N2310/315

    摘要： The present invention relates to methods and compositions for the specific inhibition of kinase suppressor of Ras (KSR). In particular, the invention provides genetic approaches and nucleic acids for the specific inhibition of KSR, particularly of KSR expression. The invention relates to antisense oligonucleotides and the expression of nucleic acid which is substantially complementary to KSR RNA. Oligonucleotide and nucleic acid compositions are provided. The invention provides methods to inhibit KSR, including inhibition of KSR expression. Methods for blocking gfRas mediated tumorigenesis, metastasis, and for cancer therapy are provided. Methods for conferring radiosensitivity to cells are also provided.

    摘要翻译： 本发明涉及用于特异性抑制Ras（KSR）激酶抑制剂的方法和组合物。 特别地，本发明提供了用于特异性抑制KSR，特别是KSR表达的遗传方法和核酸。 本发明涉及反义寡核苷酸和与KSR RNA基本上互补的核酸的表达。 提供了寡核苷酸和核酸组合物。 本发明提供抑制KSR的方法，包括抑制KSR表达。 提供阻断gfRas介导的肿瘤发生，转移和癌症治疗的方法。 还提供了赋予细胞放射敏感性的方法。

    Kinase suppressor of ras inactivation for therapy of ras mediated tumorigenesis
    3.
    发明申请
    Kinase suppressor of ras inactivation for therapy of ras mediated tumorigenesis 失效
    用于ras介导的肿瘤发生的ras灭活的激酶抑制剂

    公开(公告)号：US20060252037A1

    公开(公告)日：2006-11-09

    申请号：US10516342

    申请日：2003-05-29

    申请人： Richard Kolesnick ,  Hingmei Xing

    发明人： Richard Kolesnick ,  Hingmei Xing

    IPC分类号： C12Q1/68 ,  C07H21/02 ,  A61K48/00 ,  C12P21/06 ,  C12N9/99 ,  C07H21/04

    CPC分类号： A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0331 ,  A61K38/00 ,  C07K14/4703 ,  C12N15/1137 ,  C12N15/8509 ,  C12N2310/111 ,  C12N2310/315

    摘要： The present invention relates to methods and compositions for the specific inhibition of kinase suppressor of Ras (KSR). In particular, the invention provides genetic approaches and nucleic acids for the specific inhibition of KSR, particularly of KSR expression. The invention relates to antisense oligonucleotides and the expression of nucleic acid which is substantially complementary to KSR RNA. Oligonucleotide and nucleic acid compositions are provided. The invention provides methods to inhibit KSR, including inhibition of KSR expression. Methods for blocking gf Ras mediated tumorigenesis, metastasis, and for cancer therapy are provided.

    摘要翻译： 本发明涉及用于特异性抑制Ras（KSR）激酶抑制剂的方法和组合物。 特别地，本发明提供了用于特异性抑制KSR，特别是KSR表达的遗传方法和核酸。 本发明涉及反义寡核苷酸和与KSR RNA基本上互补的核酸的表达。 提供了寡核苷酸和核酸组合物。 本发明提供抑制KSR的方法，包括抑制KSR表达。 提供了阻断gf Ras介导的肿瘤发生，转移和癌症治疗的方法。

    Methods and compositions for the modulation of acid-sphingomyelinase-related apoptosis
    4.
    发明授权
    Methods and compositions for the modulation of acid-sphingomyelinase-related apoptosis 有权
    用于调节酸性鞘磷脂酶相关凋亡的方法和组合物

    公开(公告)号：US06790627B2

    公开(公告)日：2004-09-14

    申请号：US09928872

    申请日：2001-08-13

    申请人： Richard Kolesnick ,  Edward H. Schuchman

    发明人： Richard Kolesnick ,  Edward H. Schuchman

    IPC分类号： G01N3353

    CPC分类号： G01N33/502 ,  A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/03 ,  C12N9/16 ,  C12N15/8509 ,  G01N33/5008 ,  G01N33/5073 ,  G01N2510/00

    摘要： The present invention relates, first, to methods for the modulation of acid sphingomyelinase (ASM)-related processes, including apoptosis. Such apoptosis can include, but is not limited to, environmental stress-induced apoptosis such as, for example, ionizing radiation and/or chemotherapeutic agent-induced apoptosis. Apoptosis can be characterized by a cellular morphology comprising cellular condensation, nuclear condensation or zeiosis. The present invention further relates to methods for the identification of compounds which modulate (i.e., either increase or decrease) sensitivity to ASM-related processes, including apoptosis.

    摘要翻译： 本发明首先涉及调节酸性鞘磷脂酶（ASM）相关过程（包括细胞凋亡）的方法。 这种凋亡可以包括但不限于环境胁迫诱导的凋亡，例如电离辐射和/或化学治疗剂诱导的凋亡。 凋亡可以通过细胞形态来表征，包括细胞凝结，核缩合或大肠杆菌。 本发明还涉及用于鉴定调节（即，增加或减少）对ASM相关过程（包括凋亡）的敏感性的化合物的方法。

    Method for the modulation of acid-sphingomyelinase-related apoptosis
    5.
    发明授权
    Method for the modulation of acid-sphingomyelinase-related apoptosis 失效
    调控酸性鞘磷脂酶相关凋亡的方法

    公开(公告)号：US06274309B1

    公开(公告)日：2001-08-14

    申请号：US08687707

    申请日：1996-07-26

    申请人： Richard Kolesnick ,  Edward H. Schuchman

    发明人： Richard Kolesnick ,  Edward H. Schuchman

    IPC分类号： C12Q102

    CPC分类号： G01N33/502 ,  A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/03 ,  C12N9/16 ,  C12N15/8509 ,  G01N33/5008 ,  G01N33/5073 ,  G01N2510/00

    摘要： The present invention relates, first, to methods and compositions for the modulation of acid sphingomyelinase (ASM)-related processes, including apoptosis. Such apoptosis can include, but is not limited to, environmental stress-induced apoptosis such as, for example, ionizing radiation and/or chemotherapeutic agent-induced apoptosis. Apoptosis can be characterized by a cellular morphology comprising cellular condensation, nuclear condensation or zeiosis. The present invention further relates to methods for the identification of compounds which modulate (i.e., either increase or decrease) sensitivity to ASM-related processes, including apoptosis.

    摘要翻译： 本发明首先涉及用于调节酸性鞘磷脂酶（ASM）相关过程（包括凋亡）的方法和组合物。 这种凋亡可以包括但不限于环境应激诱导的凋亡，例如电离辐射和/或化学治疗剂诱导的凋亡。 凋亡可以通过细胞形态来表征，包括细胞凝结，核缩合或大肠杆菌。 本发明还涉及用于鉴定调节（即，增加或减少）对ASM相关过程（包括凋亡）的敏感性的化合物的方法。

    Methods for treating GI syndrome and graft versus host disease
    7.
    发明授权
    Methods for treating GI syndrome and graft versus host disease 有权
    治疗GI综合征和移植物抗宿主病的方法

    公开(公告)号：US08562993B2

    公开(公告)日：2013-10-22

    申请号：US12599280

    申请日：2008-05-06

    申请人： Jimmy Andrew Rotolo ,  Richard Kolesnick ,  Renata Pasqualini ,  Wadih Arap

    发明人： Jimmy Andrew Rotolo ,  Richard Kolesnick ,  Renata Pasqualini ,  Wadih Arap

    IPC分类号： A61K39/395

    CPC分类号： A61K31/55 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/40 ,  C07K16/44

    摘要： We have discovered that administering anti-ceramide antibody treats and prevents an array of diseases mediated by cytolytic T lymphocyte (CTLs)-induced killing and by damage to endothelial microvasculture, including radiation-induced GI syndrome, Graft vs. Host diseases, inflammatory diseases and autoimmune diseases. We have also discovered new anti-ceramide monoclonal antibodies, that have therapeutic use preferably in humanized form to treat or prevent these diseases.

    摘要翻译： 我们已经发现，施用抗神经酰胺抗体治疗并预防由细胞溶解性T淋巴细胞（CTL）介导的一系列疾病 - 诱导的杀伤和内皮微血管的损伤，包括放射诱导的GI综合征，移植物抗宿主病，炎性疾病和 自身免疫性疾病 我们还发现了新的抗神经酰胺单克隆抗体，其优选以人源化形式治疗或预防这些疾病。

    Kinase suppressor of Ras inactivation for therapy of Ras mediated tumorigenesis
    8.
    发明申请
    Kinase suppressor of Ras inactivation for therapy of Ras mediated tumorigenesis 失效
    Ras灭活激酶抑制剂治疗Ras介导的肿瘤发生

    公开(公告)号：US20050037455A1

    公开(公告)日：2005-02-17

    申请号：US10727358

    申请日：2003-12-03

    申请人： Richard Kolesnick ,  Hongmei Xing

    发明人： Richard Kolesnick ,  Hongmei Xing

    IPC分类号： A61K38/00 ,  C12N20060101 ,  C12N15/113 ,  C12N15/85 ,  C07H21/04 ,  C12N9/12

    CPC分类号： C12N15/8509 ,  A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0331 ,  A61K38/00 ,  C12N15/113 ,  C12N15/1137 ,  C12N2310/11 ,  C12N2310/111 ,  C12N2310/315

    摘要： The present invention relates to methods and compositions for the specific inhibition of kinase suppressor of Ras (KSR). In particular, the invention provides genetic approaches and nucleic acids for the specific inhibition of KSR, particularly of KSR expression. The invention relates to antisense oligonucleotides and the expression of nucleic acid which is substantially complementary to KSR RNA. Oligonucleotide and nucleic acid compositions aree provided. The invention provides methods to inhibit KSR, including inhibition of KSR expression. Methods for blocking gƒ Ras mediated tumorigenesis, metastasis, and for cancer therapy are provided. Methods for conferring radiosensitivity to cells are also provided.

    摘要翻译： 本发明涉及用于特异性抑制Ras（KSR）激酶抑制剂的方法和组合物。 特别地，本发明提供了用于特异性抑制KSR，特别是KSR表达的遗传方法和核酸。 本发明涉及反义寡核苷酸和与KSR RNA基本上互补的核酸的表达。 提供寡核苷酸和核酸组成。 本发明提供抑制KSR的方法，包括抑制KSR表达。 提供了阻断gf Ras介导的肿瘤发生，转移和癌症治疗的方法。 还提供了赋予细胞放射敏感性的方法。