公开(公告)号：US09790237B2

公开(公告)日：2017-10-17

申请号：US14737599

申请日：2015-06-12

申请人： Johnson Matthey Public Limited Company

发明人： Daniel J. Coughlin ,  Jeremy C. Wilt ,  Da-Ming Gou ,  Steven Collier

IPC分类号： C07D417/12 ,  C07D209/56 ,  C07D215/227 ,  C07D261/20 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D519/00 ,  C07D417/08 ,  C07D275/06 ,  C07D311/20 ,  C07D311/06 ,  C07D215/22 ,  C07D413/04 ,  C07D239/88 ,  C07D241/04 ,  C07D471/12 ,  C07D487/12 ,  C07D209/52 ,  C07C39/00 ,  C07D295/135 ,  C07D409/12 ,  C07D471/08

CPC分类号： C07D519/00 ,  C07C39/00 ,  C07D209/52 ,  C07D209/56 ,  C07D215/22 ,  C07D215/227 ,  C07D239/88 ,  C07D241/04 ,  C07D261/20 ,  C07D275/06 ,  C07D311/06 ,  C07D311/20 ,  C07D401/12 ,  C07D403/12 ,  C07D413/04 ,  C07D413/12 ,  C07D417/08 ,  C07D417/12 ,  C07D471/12 ,  C07D487/12

摘要： Novel processes, and intermediates, for making alkylated arylpiperazine and alkylated arylpiperidine compounds of the general formulas (I) and (VII), respectively wherein, R1 and R2 are individually selected from hydrogen, alkyl, substituted or alkyl; n=0, 1, or 2; Y=NR3R4, OR5, or SR5, where R3 and R4 are individually selected from acyl or sulfonyl, and where R5 is aryl or heteroaryl, or heterocyclic; and Ar is an aryl, heteroaryl, or heterocyclic compound.

公开(公告)号：US09957283B1

公开(公告)日：2018-05-01

申请号：US15784585

申请日：2017-10-16

申请人： Johnson Matthey Public Limited Company

发明人： Daniel J. Coughlin ,  Jeremy C. Wilt ,  Da-Ming Gou ,  Steven Collier

IPC分类号： C07D239/88 ,  C07D417/12 ,  C07D519/00 ,  C07D215/22 ,  C07D413/04 ,  C07D241/04 ,  C07D471/12 ,  C07D487/12 ,  C07D209/52 ,  C07C39/00 ,  C07D417/08 ,  C07D261/20 ,  C07D209/56 ,  C07D215/227 ,  C07D401/12 ,  C07D403/12 ,  C07D275/06 ,  C07D311/20 ,  C07D413/12 ,  C07D311/06

CPC分类号： C07D519/00 ,  C07C39/00 ,  C07D209/52 ,  C07D209/56 ,  C07D215/22 ,  C07D215/227 ,  C07D239/88 ,  C07D241/04 ,  C07D261/20 ,  C07D275/06 ,  C07D311/06 ,  C07D311/20 ,  C07D401/12 ,  C07D403/12 ,  C07D413/04 ,  C07D413/12 ,  C07D417/08 ,  C07D417/12 ,  C07D471/12 ,  C07D487/12

摘要： Novel processes, and intermediates, for making alkylated arylpiperazine and alkylated arylpiperidine compounds of the general formulas (I) and (VII), respectively wherein, R1 and R2 are individually selected from hydrogen, alkyl, substituted or alkyl; n=0, 1, or 2; Y=NR3R4, OR5, or SR5, where R3 and R4 are individually selected from acyl or sulfonyl, and where R5 is aryl or heteroaryl, or heterocyclic; and Ar is an aryl, heteroaryl, or heterocyclic compound.