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公开(公告)号:US06541499B1
公开(公告)日:2003-04-01
申请号:US09423147
申请日:2000-01-21
申请人: Jolie A Bastian , Nickolay Y Chirgadze , Michael L Denney , Matthew J Fisher , Robert J Foglesong , Richard W Harper , Mary G Johnson , Valentine J Klimkowski , Ho-Shen Lin , Michael P Lynch , Jefferson R McCowan , Shawn C Miller , Jeffrey T Mullaney , Michael E Richett , Daniel J Sall , Gerald F Smith , Kumiko Takeuchi , Jennifer M Tinsley , Michael R Wiley , Minsheng Zhang
发明人: Jolie A Bastian , Nickolay Y Chirgadze , Michael L Denney , Matthew J Fisher , Robert J Foglesong , Richard W Harper , Mary G Johnson , Valentine J Klimkowski , Ho-Shen Lin , Michael P Lynch , Jefferson R McCowan , Shawn C Miller , Jeffrey T Mullaney , Michael E Richett , Daniel J Sall , Gerald F Smith , Kumiko Takeuchi , Jennifer M Tinsley , Michael R Wiley , Minsheng Zhang
IPC分类号: A61K314196
CPC分类号: C07D231/12 , A61K31/4184 , A61K31/4196 , A61K31/497 , C07D233/56 , C07D235/18 , C07D249/08 , C07D403/12
摘要: The invention relates to novel compounds of formula (I), and their pharmaceutically acceptable salts, as defined herein, processes and intermediates for their preparation, pharmaceutical formulations comprising the novel compounds of formula (I), and the use of the compounds of formula (I) as thrombin inhibitors.
摘要翻译: 本发明涉及式(I)的新化合物及其药学上可接受的盐,如本文所定义,其制备方法和中间体,包含新型式(I)化合物的药物制剂,以及式(I)化合物 I)作为凝血酶抑制剂。
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公开(公告)号:US06172100B2
公开(公告)日:2001-01-09
申请号:US09423125
申请日:1999-12-21
申请人: Nickolay Y Chirgadze , Matthew J Fisher , Richard W Harper , Ho-Shen Lin , Jefferson R McCowan , Daniel J Sall , Gerald F Smith , Kumiko Takeuchi , Michael R Wiley , Minsheng Zhang
发明人: Nickolay Y Chirgadze , Matthew J Fisher , Richard W Harper , Ho-Shen Lin , Jefferson R McCowan , Daniel J Sall , Gerald F Smith , Kumiko Takeuchi , Michael R Wiley , Minsheng Zhang
IPC分类号: A61K31404
CPC分类号: C07D209/12 , C07D209/30
摘要: This application relates to the use as thrombin inhibitors, coagulation inhibitors and thromboembolic disorder agents of heterocyclic derivatives of formula (I) as defined herein. It also provides novel compounds of formula (I), processes and intermediates for their preparation, and pharmaceutical formulations comprising the novel compounds of formula (I).
摘要翻译: 本申请涉及作为如本文所定义的式(I)的杂环衍生物的凝血酶抑制剂,凝血抑制剂和血栓栓塞障碍剂的用途。 它还提供式(I)的新型化合物,其制备方法和中间体,以及包含式(I)的新型化合物的药物制剂。
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公开(公告)号:US06284756B1
公开(公告)日:2001-09-04
申请号:US09423166
申请日:2000-01-21
申请人: Nickolay Y Chirgadze , Richard W Harper , Todd J Kohn , Ho-Shen Lin , Jefferson R McCowan , Alan D Palkowitz , Daniel J Sall , Gerald F Smith , Kumiko Takeuchi , Michael R Wiley , Minsheng Zhang
发明人: Nickolay Y Chirgadze , Richard W Harper , Todd J Kohn , Ho-Shen Lin , Jefferson R McCowan , Alan D Palkowitz , Daniel J Sall , Gerald F Smith , Kumiko Takeuchi , Michael R Wiley , Minsheng Zhang
IPC分类号: A61K314025
CPC分类号: C07D333/58 , C07D333/56 , C07D409/10 , C07D409/12
摘要: This application relates to novel compounds of formula I (and their pharmaceutically acceptable salts), as defined herein, processes and intermediates for their preparation, pharmaceutical formulations comprising the novel compounds of formula I, and the use of the compounds of formula I as thrombin inhibitors.
摘要翻译: 本申请涉及本文定义的式I(及其药学上可接受的盐)的新型化合物,其制备方法和中间体,包含式I的新型化合物的药物制剂以及式I化合物作为凝血酶抑制剂的用途 。
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公开(公告)号:US06200967B1
公开(公告)日:2001-03-13
申请号:US09202626
申请日:1998-12-17
IPC分类号: C07D22500
CPC分类号: C07D401/06 , A61K38/00 , C07C311/06 , C07D205/04 , C07D207/16 , C07D209/42 , C07D217/26 , C07K5/0222 , C07K5/06078 , C07K5/06139 , C07K5/06191
摘要: This invention relates to a compound of the Formula I X—C(O)—Y—G—R I (wherein X, Y, G and R have the values defined in the description), or a pharmaceutically acceptable salt thereof, processes and intermediates for the preparation of such a compound or salt, pharmaceutical compositions comprising such a compound or salt and methods of their use as thrombin inhibitors, coagulation inhibitors and agents for the treatment of thromboembolic disorders.
摘要翻译: 本发明涉及式I化合物(其中X,Y,G和R具有说明书中定义的值)或其药学上可接受的盐,用于制备这种化合物或盐的方法和中间体,药物组合物 包括这种化合物或盐以及它们用作凝血酶抑制剂,凝血抑制剂和治疗血栓栓塞障碍的药物的方法。
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5.
公开(公告)号:US06534650B2
公开(公告)日:2003-03-18
申请号:US09803345
申请日:2001-03-09
IPC分类号: C07D20506
CPC分类号: C07D401/06 , A61K38/00 , C07C311/06 , C07D205/04 , C07D207/16 , C07D209/42 , C07D217/26 , C07K5/0222 , C07K5/06078 , C07K5/06139 , C07K5/06191
摘要: This invention relates to compounds of Formula V H—Y—G—R V and Formula VI (wherein f, X, Y, G and R have the values defined in the description) which are useful as intermediates for the preparation of compounds, or pharmaceutically acceptable salts thereof, which are useful as thrombin inhibitors, coagulation inhibitors and agents for the treatment of thromboembolic disorders.
摘要翻译: 本发明涉及式V和式VI化合物(其中f,X,Y,G和R具有描述中定义的值),其可用作制备化合物或其药学上可接受的盐的中间体,其可用作 凝血酶抑制剂,凝血抑制剂和治疗血栓栓塞障碍的药剂。
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