-
公开(公告)号：US20120208781A1
公开(公告)日：2012-08-16
申请号：US13294429
申请日：2011-11-11
申请人： Jon B. Bruss , Corwin F. Kostrub , Eliana Saxon Armstrong , Robert T. Cass , George H. Miller , James Bradley Aggen , Adam Aaron Goldblum , Paola Dozzo , Martin Sheringham Linsell
发明人： Jon B. Bruss , Corwin F. Kostrub , Eliana Saxon Armstrong , Robert T. Cass , George H. Miller , James Bradley Aggen , Adam Aaron Goldblum , Paola Dozzo , Martin Sheringham Linsell
IPC分类号： A61K31/7036 , A61K31/7052 , A61K31/7056 , A61P31/04 , A61K31/706
CPC分类号： C07H15/234 , A61K31/7036 , C07H15/236 , Y02A50/473
摘要： The present invention provides new aminoglycoside dosing regimens associated with enhanced microbicidal activity and reduced nephrotoxicity, as well as methods of using these dosing regimens to treat various bacterial infections.
摘要翻译： 本发明提供了与增强的杀微生物活性和减少的肾毒性相关的新的氨基糖苷给药方案，以及使用这些给药方案来治疗各种细菌感染的方法。
-
公开(公告)号：US08653042B2
公开(公告)日：2014-02-18
申请号：US13295233
申请日：2011-11-14
CPC分类号： C07H15/234 , A61K31/7036
摘要： Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q3, R1, R2 and R3 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
摘要翻译： 公开了具有抗菌活性的化合物。 所述化合物具有以下结构（I）：包括立体异构体，其药学上可接受的盐和前药，其中Q1，Q2，Q3，R1，R2和R3如本文所定义。 还公开了与这种化合物的制备和使用相关的方法以及包含这些化合物的药物组合物。
-
公开(公告)号：US08481502B2
公开(公告)日：2013-07-09
申请号：US13441696
申请日：2012-04-06
申请人： James Bradley Aggen , Paola Dozzo , Adam Aaron Goldblum , Darin James Hildebrandt , Timothy Robert Kane , Micah James Gliedt , Martin Sheringham Linsell
发明人： James Bradley Aggen , Paola Dozzo , Adam Aaron Goldblum , Darin James Hildebrandt , Timothy Robert Kane , Micah James Gliedt , Martin Sheringham Linsell
CPC分类号： C07H15/232
摘要： Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q5, R1, R2, R3, Z1 and Z2 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
摘要翻译： 公开了具有抗菌活性的化合物。 该化合物具有以下结构（I）：包括立体异构体，其药学上可接受的盐和前药，其中Q 1，Q 2，Q 5，R 1，R 2，R 3，Z 1和Z 2如本文所定义。 还公开了与这种化合物的制备和使用相关的方法以及包含这些化合物的药物组合物。
-
公开(公告)号：US08318685B2
公开(公告)日：2012-11-27
申请号：US13295219
申请日：2011-11-14
申请人： Adam Aaron Goldblum , Paola Dozzo , Timothy Robert Kane , James Bradley Aggen , Martin Sheringham Linsell , Darin James Hildebrandt , Micah James Gliedt
发明人： Adam Aaron Goldblum , Paola Dozzo , Timothy Robert Kane , James Bradley Aggen , Martin Sheringham Linsell , Darin James Hildebrandt , Micah James Gliedt
CPC分类号： C07H15/232
摘要： Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein Q1 and Q2 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
摘要翻译： 公开了具有抗菌活性的化合物。 该化合物具有以下结构（I）：包括其立体异构体，前药和药学上可接受的盐，其中Q1和Q2如本文所定义。 还公开了与这种化合物的制备和使用相关的方法以及包含这些化合物的药物组合物。
-
公开(公告)号：US20120258925A1
公开(公告)日：2012-10-11
申请号：US13441696
申请日：2012-04-06
申请人： James Bradley Aggen , Paola Dozzo , Adam Aaron Goldblum , Darin James Hildebrandt , Timothy Robert Kane , Micah James Gliedt , Martin Sheringham Linsell
发明人： James Bradley Aggen , Paola Dozzo , Adam Aaron Goldblum , Darin James Hildebrandt , Timothy Robert Kane , Micah James Gliedt , Martin Sheringham Linsell
IPC分类号： A61K31/7036 , A61P31/04 , C07H15/232
CPC分类号： C07H15/232
摘要： Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q5, R1, R2, R3, Z1 and Z2 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
摘要翻译： 公开了具有抗菌活性的化合物。 该化合物具有以下结构（I）：包括立体异构体，其药学上可接受的盐和前药，其中Q 1，Q 2，Q 5，R 1，R 2，R 3，Z 1和Z 2如本文所定义。 还公开了与这种化合物的制备和使用相关的方法以及包含这些化合物的药物组合物。
-
公开(公告)号：US20120283208A1
公开(公告)日：2012-11-08
申请号：US13441699
申请日：2012-04-06
申请人： James Bradley Aggen , Adam Aaron Goldblum , Paola Dozzo , Darin James Hildebrandt , Timothy Robert Kane , Micah James Gliedt , Martin Sheringham Linsell
发明人： James Bradley Aggen , Adam Aaron Goldblum , Paola Dozzo , Darin James Hildebrandt , Timothy Robert Kane , Micah James Gliedt , Martin Sheringham Linsell
IPC分类号： A61K31/7036 , A61P31/04 , A61K31/7052 , A61K31/706 , C07H15/26 , C07H15/232
CPC分类号： C07H15/232
摘要： Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, R1, R2, R3, Z1 and Z2 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
摘要翻译： 公开了具有抗菌活性的化合物。 所述化合物具有以下结构（I）：其包括立体异构体，其药学上可接受的盐和前药，其中Q1，Q2，R1，R2，R3，Z1和Z2如本文所定义。 还公开了与这种化合物的制备和使用相关的方法以及包含这些化合物的药物组合物。
-
公开(公告)号：US20120172332A1
公开(公告)日：2012-07-05
申请号：US13082143
申请日：2011-04-07
申请人： James Bradley Aggen , Martin Sheringham Linsell , Adam Aaron Goldblum , Darin James Hildebrandt , Timothy Robert Kane , Paola Dozzo , Micah James Gliedt , Heinz Ernst Moser
发明人： James Bradley Aggen , Martin Sheringham Linsell , Adam Aaron Goldblum , Darin James Hildebrandt , Timothy Robert Kane , Paola Dozzo , Micah James Gliedt , Heinz Ernst Moser
IPC分类号： A61K31/7008 , A61P31/04 , C07H5/06
CPC分类号： C07H15/232
摘要： Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, R1, R2 and R3 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
摘要翻译： 公开了具有抗菌活性的化合物。 该化合物具有以下结构（I）：包括立体异构体，其药学上可接受的盐和前药，其中Q1，Q2，R1，R2和R3如本文所定义。 还公开了与这种化合物的制备和使用相关的方法以及包含这些化合物的药物组合物。
-
公开(公告)号：US08367625B2
公开(公告)日：2013-02-05
申请号：US13082141
申请日：2011-04-07
申请人： James Bradley Aggen , Martin Sheringham Linsell , Adam Aaron Goldblum , Darin James Hildebrandt , Timothy Robert Kane , Paola Dozzo , Micah James Gliedt , Heinz Ernst Moser
发明人： James Bradley Aggen , Martin Sheringham Linsell , Adam Aaron Goldblum , Darin James Hildebrandt , Timothy Robert Kane , Paola Dozzo , Micah James Gliedt , Heinz Ernst Moser
CPC分类号： C07H15/232
摘要： Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, R1, R2 and R3 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
-
公开(公告)号：US20120283209A1
公开(公告)日：2012-11-08
申请号：US13441701
申请日：2012-04-06
IPC分类号： C07H15/232 , C07H23/00 , A61P31/04 , A61K31/7036
CPC分类号： C07H15/232
摘要： Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, R1, R2 and R3 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
-
公开(公告)号：US20120184501A1
公开(公告)日：2012-07-19
申请号：US13295227
申请日：2011-11-14
IPC分类号： A61K31/7036 , A61K31/7052 , C07H17/02 , C07H15/236 , A61P31/04
CPC分类号： C07H15/236
摘要： Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q3, R11 and R12 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
摘要翻译： 公开了具有抗菌活性的化合物。 该化合物具有以下结构（I）：包括其立体异构体，药学上可接受的盐和前药，其中Q1，Q2，Q3，R11和R12如本文所定义。 还公开了与这种化合物的制备和使用相关的方法以及包含这些化合物的药物组合物。
-
-
-
-
-
-
-
-
-
搜索结果
27 条记录 (耗时 0.202 秒)
