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    Circuit and Method for Service Clock Recovery
    1.
    发明申请
    Circuit and Method for Service Clock Recovery 审中-公开
    电路和服务时钟恢复方法

    公开(公告)号：US20070019686A1

    公开(公告)日：2007-01-25

    申请号：US11530618

    申请日：2006-09-11

    申请人： Jonathan Belk ,  Richard Nichols

    发明人： Jonathan Belk ,  Richard Nichols

    IPC分类号： H04J3/06

    CPC分类号： H04J3/0632

    摘要： A method for controlling a local clock in a node coupled to a packet network is disclosed. The method involves generating a first control signal based on RTS values received during a first period of time and generating at least one additional control signal based on RTS values received during at least one additional period of time. The method further involves selecting one of the first and at least one additional control signals to control the frequency of a local clock.

    摘要翻译： 公开了一种用于控制耦合到分组网络的节点中的本地时钟的方法。 该方法包括基于在第一时间段期间接收的RTS值产生第一控制信号，并且基于在至少一个附加时间段期间接收的RTS值产生至少一个附加控制信号。 该方法还包括选择第一和至少一个附加控制信号之一来控制本地时钟的频率。

    Antibodies to Erythropoietin Receptor and Uses Thereof
    3.
    发明申请
    Antibodies to Erythropoietin Receptor and Uses Thereof 审中-公开
    抗红细胞生成素受体的抗体及其用途

    公开(公告)号：US20080038265A1

    公开(公告)日：2008-02-14

    申请号：US11614772

    申请日：2006-12-21

    申请人： Edward Reilly ,  Susan Lacy ,  Emma Fung ,  Jonathan Belk ,  Michael Roguska ,  Vincent Stoll ,  Clarissa Jakob

    发明人： Edward Reilly ,  Susan Lacy ,  Emma Fung ,  Jonathan Belk ,  Michael Roguska ,  Vincent Stoll ,  Clarissa Jakob

    IPC分类号： A61K39/395 ,  A61P43/00 ,  C07K16/24 ,  C07K7/06 ,  G06G7/60

    CPC分类号： C07K16/2863 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/74 ,  C07K2317/92

    摘要： The present invention relates to antibodies and antigen-binding portions thereof that bind to and activate an erythropoietin receptor. The invention also relates to nucleic acid sequences encoding such antibodies and antigen-binding portions. The present invention further relates to methods of activating the endogenous activity of an erythropoietin receptor in a mammal using said antibodies and antigen-binding portions, methods of treatment, as well as pharmaceutical compositions comprising said antibodies and antigen-binding portions. The invention further provides compositions and crystals of an erythropoietin receptor in complex with an anti-erythropoietin receptor antibody. Specifically, the high-resolution structure provides binding sites defined by the structure coordinated determined herein.

    摘要翻译： 本发明涉及结合并激活促红细胞生成素受体的抗体及其抗原结合部分。 本发明还涉及编码这种抗体和抗原结合部分的核酸序列。 本发明还涉及使用所述抗体和抗原结合部分，治疗方法以及包含所述抗体和抗原结合部分的药物组合物来激活哺乳动物中促红细胞生成素受体的内源性活性的方法。 本发明还提供与抗促红细胞生成素受体抗体复合的促红细胞生成素受体的组合物和晶体。 具体地，高分辨率结构提供由本文确定的结构所定义的结合位点。

    Antibodies to erythropoietin receptor and uses thereof
    4.
    发明申请
    Antibodies to erythropoietin receptor and uses thereof 审中-公开
    促红细胞生成素受体的抗体及其用途

    公开(公告)号：US20060018902A1

    公开(公告)日：2006-01-26

    申请号：US11102424

    申请日：2005-04-08

    申请人： Edward Reilly ,  Susan Lacy ,  Emma Fung ,  Jonathan Belk ,  Michael Roguska

    发明人： Edward Reilly ,  Susan Lacy ,  Emma Fung ,  Jonathan Belk ,  Michael Roguska

    IPC分类号： A61K39/395 ,  C07K16/28

    CPC分类号： C07K16/2863 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/74 ,  C07K2317/92

    摘要： The present invention relates to antibodies and antigen-binding portions thereof that bind to and activate an erythropoietin receptor. The invention also relates to nucleic acid sequences encoding such antibodies and antigen-binding portions. The present invention further relates to methods of activating the endogenous activity of an erythropoietin receptor in a mammal using said antibodies and antigen-binding portions, methods of treatment, as well as pharmaceutical compositions comprising said antibodies and antigen-binding portions.

    摘要翻译： 本发明涉及结合并激活促红细胞生成素受体的抗体及其抗原结合部分。 本发明还涉及编码这种抗体和抗原结合部分的核酸序列。 本发明还涉及使用所述抗体和抗原结合部分，治疗方法以及包含所述抗体和抗原结合部分的药物组合物来激活哺乳动物中促红细胞生成素受体的内源性活性的方法。