公开(公告)号：US06610685B2

公开(公告)日：2003-08-26

申请号：US10017978

申请日：2001-12-14

申请人： Jonathan Mark Bentley ,  Michael John Bickerdike ,  Paul Hebeisen ,  Guy Anthony Kennett ,  Sean Lightowler ,  Patrizio Mattei ,  Jacques Mizrahi ,  Timothy James Morley ,  Jean-Marc Plancher ,  Hans Richter ,  Stephan Roever ,  Sven Taylor ,  Steven Paul Vickers

发明人： Jonathan Mark Bentley ,  Michael John Bickerdike ,  Paul Hebeisen ,  Guy Anthony Kennett ,  Sean Lightowler ,  Patrizio Mattei ,  Jacques Mizrahi ,  Timothy James Morley ,  Jean-Marc Plancher ,  Hans Richter ,  Stephan Roever ,  Sven Taylor ,  Steven Paul Vickers

IPC分类号： C07D48704

CPC分类号： C07D487/04

摘要： The present invention is a chemical compound of formula (I) or a pharmaceutically acceptable salt, solvate and ester thereof, wherein R1 to R4 and n are as defined in the specification. A compound of formula 1 is useful as a pharmaceutical composition for the treatment or prevention of disorders of the central nervous system, cardiovascular disorders, gastrointestinal disorders, diabetes, obesity and sleep apnoea.

摘要翻译： 本发明是式（I）化合物或其药学上可接受的盐，溶剂化物和酯，其中R1至R4和n如说明书中所定义。 式1的化合物可用作治疗或预防中枢神经系统疾病，心血管疾病，胃肠道疾病，糖尿病，肥胖症和睡眠呼吸暂停的药物组合物。