公开(公告)号：US06589548B1

公开(公告)日：2003-07-08

申请号：US09700380

申请日：2000-11-14

申请人： Jong Eun Oh ,  Keon Hyoung Lee ,  Tae Gwan Park ,  Yoon Sung Nam

发明人： Jong Eun Oh ,  Keon Hyoung Lee ,  Tae Gwan Park ,  Yoon Sung Nam

IPC分类号： A61F200

CPC分类号： B82Y5/00 ,  A61K47/6927 ,  A61K47/6937

摘要： The present invention relates to a molecular sustained controlled release system constructed by the conjugation of molecules to be released with biodegradable polyester polymer via covalent bond and method for preparation thereof. In accordance with the present invention, the system may be formulated into microspheres, nanoparticles, or films. The molecular release rate from the above system can be regulated to be proportional to the chemical degradation rate of the biodegradable polyester polymers, resulting in near zero order kinetics profile of release without showing a burst effect, Moreover, a high loading efficiency of hydrophilic drugs can be achieved.

摘要翻译： 本发明涉及通过共价键将待释放的分子与可生物降解的聚酯聚合物共轭而构成的分子持续控制释放系统及其制备方法。 根据本发明，该系统可以配制成微球，纳米颗粒或薄膜。 可以调节上述体系的分子释放速率与生物可降解聚酯聚合物的化学降解速率成比例，导致释放的接近零级动力学特征，而不发生爆裂效应。此外，亲水性药物的高负载效率可以 实现。

公开(公告)号：US07163698B2

公开(公告)日：2007-01-16

申请号：US10423536

申请日：2003-04-25

申请人： Jong Eun Oh ,  Keon Hyoung Lee ,  Tae Gwan Park ,  Yoon Sung Nam

发明人： Jong Eun Oh ,  Keon Hyoung Lee ,  Tae Gwan Park ,  Yoon Sung Nam

IPC分类号： A61K9/14 ,  A61K9/16 ,  A61K9/50

CPC分类号： B82Y5/00 ,  A61K47/6927 ,  A61K47/6937

摘要： The present invention relates to the molecular sustained controlled release system constructed by the conjugation of molecules to be released with biodegradable polyester polymer via covalent bond and method for preparation thereof. In accordance with the present invention, the system may be formulated into microspheres, nanoparticles, or films. The molecular release rate from the above system can be regulated to be proportional to the chemical degradation rate of the biodegradable polyester polymers, resulting in near zero order kinetics profile of release without showing a burst effect. Moreover, the high loading efficiency of hydrophilic drugs can be achieved.

摘要翻译： 本发明涉及通过共价键与待分解的分子与可生物降解的聚酯聚合物共轭构成的分子持续控制释放体系及其制备方法。 根据本发明，该系统可以配制成微球，纳米颗粒或薄膜。 可以调节上述体系的分子释放速率与可生物降解的聚酯聚合物的化学降解速率成比例，导致释放的接近零级动力学特征，而不发生爆裂效应。 此外，可以实现亲水药物的高负载效率。