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    Video codec including pipelined processing elements
    1.
    发明授权
    Video codec including pipelined processing elements 失效
    视频编解码器，包括流水线处理元件

    公开(公告)号：US5046080A

    公开(公告)日：1991-09-03

    申请号：US529887

    申请日：1990-05-29

    申请人： Jong S. Lee ,  Oh W. Kwon ,  Joo H. Jeong ,  Ji H. Kim ,  Myoung H. Lee

    发明人： Jong S. Lee ,  Oh W. Kwon ,  Joo H. Jeong ,  Ji H. Kim ,  Myoung H. Lee

    IPC分类号： G06F15/167 ,  G06T11/60 ,  H04M9/00 ,  H04N5/907 ,  H04N7/14 ,  H04N7/50

    CPC分类号： G06F15/167 ,  H04N19/42 ,  H04N19/61 ,  H04N5/907 ,  H04N7/148

    摘要： A videophone system for providing videophone service within narrow band digital network, based on pipelined processing elements, includes source codec means coupled to the image bus, including numerous processing elements of which processing element has DSP (Digital Signal Processor) module, local memory module coupled to the DSP module, FIFO (First Input First Output) memory module coupled to the DSP module and the local memory module, and image bus interface module coupled to the DSP module and the local memory module and the image bus, wherein communications between the processor elements is performed via the pipeline and common memory means coupled to the VME bus and the image bus, for storing message data for synchronization and communication between the processing elements.

    摘要翻译： 一种用于在窄带数字网络内基于流水线处理元件提供可视电话服务的视频电话系统包括耦合到图像总线的源编解码器装置，包括处理元件具有DSP（数字信号处理器）模块，本地存储器模块耦合的多个处理元件 耦合到DSP模块和本地存储器模块的FIFO（第一输入第一输出）存储器模块，以及耦合到DSP模块和本地存储器模块和图像总线的图像总线接口模块，其中处理器 通过流水线执行元件，并且耦合到VME总线和图像总线的公共存储器装置，用于存储用于在处理元件之间进行同步和通信的消息数据。

    Enhancement of thrombolytic therapy with deglycosylated forms of plasminogen
    2.
    发明授权
    Enhancement of thrombolytic therapy with deglycosylated forms of plasminogen 失效
    用去糖基化形式的纤溶酶原增强血栓溶解治疗

    公开(公告)号：US5637299A

    公开(公告)日：1997-06-10

    申请号：US461172

    申请日：1995-06-05

    申请人： Jan McDonagh ,  Myoung H. Lee

    发明人： Jan McDonagh ,  Myoung H. Lee

    IPC分类号： A61K38/16 ,  A61K38/48 ,  A61K38/49 ,  C12N9/64 ,  C12N9/68

    CPC分类号： A61K38/484 ,  A61K38/166 ,  A61K38/49

    摘要： This invention provides an improved method for enhancing the activity of thrombolytic agents, including t-PA, scu-PA, tcu-PA, streptokinase, acylated plasminogen-streptokinase activator complex (APSAC), mixtures of these, and other activators of plasminogen. The enhancement method comprises supplementation of plasma plasminogen levels with deglycosylated forms of glu- and lys-plasminogen. Deglycosylated plasminogen refers herein to glu- or lys-plasminogen 2 having a single oligosaccharide chain at Thr.sub.345, plasminogens having a single oligosaccharide chain at Asn.sub.288, and unglycosylated forms of plasminogen. The work described herein shows that a less glycosylated form of plasminogen (glu-plasminogen 2) has a higher affinity for fibrin clots than a more glycosylated plasminogen (glu-plasminogen 1). Based on this work, it is believed that glycosylation of plasminogen inhibits binding of plasminogen to fibrin clots, perhaps due to steric hindrance, and further, that deglycosylated forms of plasminogen may be more effective enhancers of scu-PA in thrombolytic therapy than fully glycosylated forms of plasminogen. Improved enhancement of the activity of thrombolytic agents allows the use of lower therapeutic doses and thus, is expected to relieve some of the bleeding and other side effects of thrombolytic therapy.

    摘要翻译： 本发明提供了一种增强溶栓剂（包括t-PA，scu-PA，tcu-PA，链激酶，酰化纤溶酶原 - 链激酶激活剂复合物（APSAC））及其混合物和纤溶酶原激活剂的活性的改进方法。 增强方法包括用去糖基化形式的葡萄糖和溶血纤溶酶原补充血浆纤溶酶原水平。 糖基化纤维蛋白溶酶原是指在Thr345具有单个寡糖链的葡糖或溶酶体纤溶酶原2，在Asn288具有单个寡糖链的纤溶酶原和未糖基化形式的纤溶酶原。 本文所述的工作表明，较多糖基化的纤溶酶原（glu-plasminogen 1），较少的糖基化形式的纤溶酶原（glu-plasminogen 2）对纤维蛋白凝块具有更高的亲和力。 基于这项工作，据信纤维蛋白溶酶原的糖基化抑制纤维蛋白溶酶原与纤维蛋白凝块的结合，这可能是由于空间位阻引起的，此外，溶纤溶酶原的去糖基化形式可能是完全糖基化形式的溶栓治疗中scu-PA的更有效的增强剂 的纤溶酶原。 改善溶栓剂活性的增强使得可以使用较低的治疗剂量，因此预期可以缓解溶栓治疗的一些出血和其它副作用。