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1.发明授权Method for controlling fibrosis and other pathological deposits in tissues comprising administering a GHRP-6 composition 有权用于控制组织中的纤维化和其它病理沉积物的方法，包括施用GHRP-6组合物公开(公告)号：US08722626B2
公开(公告)日：2014-05-13
申请号：US13150526
申请日：2011-06-01
申请人： Jorge Berlanga Acosta , Danay Cibrian Vera , Diana Garcia Del Barco Herrera , Gerardo Enrique Guillén Nieto , José Suarez Alba , Ernesto Lopez Mola , Manuel Selman-Housein Sosa , Mariela Vazquez Castillo
发明人： Jorge Berlanga Acosta , Danay Cibrian Vera , Diana Garcia Del Barco Herrera , Gerardo Enrique Guillén Nieto , José Suarez Alba , Ernesto Lopez Mola , Manuel Selman-Housein Sosa , Mariela Vazquez Castillo
摘要： The present invention is related to the use of secretagogue peptides repeatedly administered as part of a pharmaceutical composition that prevent and eradicate the deposition of pathological fibrotic material in parenchymal tissues of internal organs like the liver, lungs, esophagus, small intestine, kidneys, blood vessels, joints, and other systemic forms of cutaneous fibrosis of any etiopathogenesis. Additionally, these peptides prevent and eradicate deposition of amiloid and hyaline materials in any of their correspondent chemical forms and tissue manifestations in the brain, cerebellum, blood vessels, liver, intestines, kidneys, spleen, pancreas, joints and the skin, among others. By this way, cellular, tissular and organ dysfunctions generated by these depositions are corrected. The peptides of the present invention are infiltrated or topically applied, contributing to prevent and eradicate keloids and hypertrophic scars in the skin, derived as sequelae of burns and other cutaneous trauma.
摘要翻译： 本发明涉及使用作为药物组合物的一部分反复施用的促分泌素肽，其用于预防和消除病理性纤维化物质在诸如肝，肺，食管，小肠，肾脏，血管等脏器的实质组织中的沉积 ，关节和其他全身形式的皮肤纤维化的任何发病机制。 此外，这些肽预防和消除了在脑，小脑，血管，肝，肠，肾，脾脏，胰腺，关节和皮肤等中的任何相应的化学形式和组织表现的淀粉样和透明物质的沉积。 通过这种方式，校正由这些沉积产生的细胞，组织和器官功能障碍。 本发明的肽被渗透或局部应用，有助于预防和消除作为烧伤和其它皮肤创伤后遗症的皮肤中的瘢痕疙瘩和肥厚性瘢痕。
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2.发明申请Pharmaceutical Composition Containing GHRP-6 To Prevent And Eliminate Fibrosis And Other Pathological Deposits In Tissues 有权含有GHRP-6的药物组合物用于预防和消除组织中的纤维化和其他病理沉积公开(公告)号：US20110230415A1
公开(公告)日：2011-09-22
申请号：US13150526
申请日：2011-06-01
申请人： Jorge Berlanga Acosta , Danay Cibrian Vera , Diana Garcia Del Barco Herrera , Gerardo Enrique Guillén Nieto , José Suarez Alba , Ernesto Lopez Mola , Manuel Selman-Housein Sosa , Mariela Vazquez Castillo
发明人： Jorge Berlanga Acosta , Danay Cibrian Vera , Diana Garcia Del Barco Herrera , Gerardo Enrique Guillén Nieto , José Suarez Alba , Ernesto Lopez Mola , Manuel Selman-Housein Sosa , Mariela Vazquez Castillo
摘要： The present invention is related to the use of secretagogue peptides repeatedly administered as part of a pharmaceutical composition that prevent and eradicate the deposition of pathological fibrotic material in parenchymal tissues of internal organs like the liver, lungs, esophagus, small intestine, kidneys, blood vessels, joints, and other systemic forms of cutaneous fibrosis of any etiopathogenesis. Additionally, these peptides prevent and eradicate deposition of amiloid and hyaline materials in any of their correspondent chemical forms and tissue manifestations in the brain, cerebellum, blood vessels, liver, intestines, kidneys, spleen, pancreas, joints and the skin, among others. By this way, cellular, tissular and organ dysfunctions generated by these depositions are corrected. The peptides of the present invention are infiltrated or topically applied, contributing to prevent and eradicate keloids and hypertrophic scars in the skin, derived as sequelae of burns and other cutaneous trauma.
摘要翻译： 本发明涉及使用作为药物组合物的一部分反复施用的促分泌素肽，其用于预防和消除病理性纤维化物质在诸如肝，肺，食管，小肠，肾脏，血管等脏器的实质组织中的沉积 ，关节和其他全身形式的皮肤纤维化的任何发病机制。 此外，这些肽预防和消除了在脑，小脑，血管，肝，肠，肾，脾脏，胰腺，关节和皮肤等中的任何相应的化学形式和组织表现的淀粉样和透明物质的沉积。 通过这种方式，校正由这些沉积产生的细胞，组织和器官功能障碍。 本发明的肽被渗透或局部应用，有助于预防和消除作为烧伤和其它皮肤创伤后遗症的皮肤中的瘢痕疙瘩和肥厚性瘢痕。
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3.发明申请PHARMACEUTICAL COMPOSITION CONTAINING GHRP-6 TO PREVENT AND ELIMINATE FIBROSIS AND OTHER PATHOLOGICAL DEPOSITS IN TISSUES 审中-公开包含GHRP-6的药物组合物可预防和消除组织中的纤维化和其他病理沉积物公开(公告)号：US20090221512A1
公开(公告)日：2009-09-03
申请号：US12281018
申请日：2007-02-23
申请人： Jorge Berlanga Acosta , Danay Cibrian Vera , Diana Garcia Del Barco Herrera , Gerardo Enrique Guillen Nieto , Jose Suarez Alba , Ernesto Lopez Mola , Manuel Selman-Housein Sosa , Mariela Vazquez Castillo
发明人： Jorge Berlanga Acosta , Danay Cibrian Vera , Diana Garcia Del Barco Herrera , Gerardo Enrique Guillen Nieto , Jose Suarez Alba , Ernesto Lopez Mola , Manuel Selman-Housein Sosa , Mariela Vazquez Castillo
IPC分类号： A61K38/08
摘要： The present invention is related to the use of secretagogue peptides repeatedly administered as part of a pharmaceutical composition that prevent and eradicate the deposition of pathological fibrotic material in parenchymal tissues of internal organs like the liver, lungs, esophagus, small intestine, kidneys, blood vessels, joints, and other systemic forms of cutaneous fibrosis of any etiopathogenesis. Additionally, these peptides prevent and eradicate deposition of amiloid and hyaline materials in any of their correspondent chemical forms and tissue manifestations in the brain, cerebellum, blood vessels, liver, intestines, kidneys, spleen, pancreas, joints and the skin, among others. By this way, cellular, tissular and organ dysfunctions generated by these depositions are corrected. The peptides of the present invention are infiltrated or topically applied, contributing to prevent and eradicate keloids and hypertrophic scars in the skin, derived as sequelae of burns and other cutaneous trauma.
摘要翻译： 本发明涉及使用作为药物组合物的一部分反复施用的促分泌素肽，其用于预防和消除病理性纤维化物质在诸如肝，肺，食管，小肠，肾脏，血管等脏器的实质组织中的沉积 ，关节和其他全身形式的皮肤纤维化的任何发病机制。 此外，这些肽预防和消除了在脑，小脑，血管，肝，肠，肾，脾脏，胰腺，关节和皮肤等中的任何相应的化学形式和组织表现的淀粉样和透明物质的沉积。 通过这种方式，校正由这些沉积产生的细胞，组织和器官功能障碍。 本发明的肽被渗透或局部应用，有助于预防和消除作为烧伤和其它皮肤创伤后遗症的皮肤中的瘢痕疙瘩和肥厚性瘢痕。
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公开(公告)号：US09375459B2
公开(公告)日：2016-06-28
申请号：US14005855
申请日：2012-03-21
申请人： María del Carmen Abrahantes Pérez , Glay Chinea Santiago , Eduardo Martínez Diaz , Hilda Elisa Garay Pérez , Osvaldo Reyes Acosta , Ernesto Lopez Mola , Cruz Matilde Lopez Abad , Sonia Gonzalez Blanco
发明人： María del Carmen Abrahantes Pérez , Glay Chinea Santiago , Eduardo Martínez Diaz , Hilda Elisa Garay Pérez , Osvaldo Reyes Acosta , Ernesto Lopez Mola , Cruz Matilde Lopez Abad , Sonia Gonzalez Blanco
IPC分类号： A61K38/12 , A61K31/4025 , A61K45/06 , C07K7/64 , C07K7/06 , C07K7/08 , A61K47/48 , A61K38/00 , A61K9/00 , A61K9/127 , A61K9/50
CPC分类号： A61K38/12 , A61K9/0019 , A61K9/127 , A61K9/5031 , A61K31/4025 , A61K38/00 , A61K45/06 , A61K47/60 , C07K7/06 , C07K7/08 , C07K7/64
摘要： The present invention comprises cyclic peptides bearing antitumor and antiangiogenic properties, as well as their corresponding pharmaceutically-suitable salts and also pharmaceutical compositions containing it. These cyclic peptides are used to prepare medicines for human and/or veterinary therapeutics, and additionally in diagnosis. These compounds can be used to detect, monitor and/or control a range of cellular proliferation-related disorders, such as oncological diseases and undesired angiogenesis. Moreover, they can be included as part of controlled release systems, and used more precisely in the field of nanobiotechnology, either because of their self-assembly capacity or as part of other systems.
摘要翻译： 本发明包括具有抗肿瘤和抗血管生成特性的环肽，以及它们相应的药学上合适的盐以及含有它的药物组合物。 这些环肽用于制备用于人和/或兽医治疗剂的药物，另外用于诊断。 这些化合物可用于检测，监测和/或控制一系列细胞增殖相关疾病，例如肿瘤疾病和不期望的血管生成。 此外，它们可以作为控制释放系统的一部分进行纳入，并且在纳米生物技术领域更加精确地使用，无论是由于其自组装能力还是作为其他系统的一部分。
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公开(公告)号：US20140112976A1
公开(公告)日：2014-04-24
申请号：US14005855
申请日：2012-03-21
申请人： María del Carmen Abrahantes Pérez , Glay Chinea Santiago , Eduardo Martínez Díaz , Hilda Elisa Garay Perez , Osvaldo Reyes Acosta , Ernesto Lopez Mola , Cruz Matilde Lopez Abad , Sonia Gonzalez Blanco
发明人： María del Carmen Abrahantes Pérez , Glay Chinea Santiago , Eduardo Martínez Díaz , Hilda Elisa Garay Perez , Osvaldo Reyes Acosta , Ernesto Lopez Mola , Cruz Matilde Lopez Abad , Sonia Gonzalez Blanco
IPC分类号： A61K38/12 , A61K31/4025 , A61K45/06 , C07K7/64
CPC分类号： A61K38/12 , A61K9/0019 , A61K9/127 , A61K9/5031 , A61K31/4025 , A61K38/00 , A61K45/06 , A61K47/60 , C07K7/06 , C07K7/08 , C07K7/64
摘要： The present invention comprises cyclic peptides bearing antitumor and antiangiogenic properties, as well as their corresponding pharmaceutically-suitable salts and also pharmaceutical compositions containing it. These cyclic peptides are used to prepare medicines for human and/or veterinary therapeutics, and additionally in diagnosis. These compounds can be used to detect, monitor and/or control a range of cellular proliferation-related disorders, such as oncological diseases and undesired angiogenesis. Moreover, they can be included as part of controlled release systems, and used more precisely in the field of nanobiotechnology, either because of their self-assembly capacity or as part of other systems.
摘要翻译： 本发明包括具有抗肿瘤和抗血管生成特性的环肽，以及它们相应的药学上合适的盐以及含有它的药物组合物。 这些环肽用于制备用于人和/或兽医治疗剂的药物，另外用于诊断。 这些化合物可用于检测，监测和/或控制一系列细胞增殖相关疾病，例如肿瘤疾病和不期望的血管生成。 此外，它们可以作为控制释放系统的一部分进行纳入，并且在纳米生物技术领域更加精确地使用，无论是由于其自组装能力还是作为其他系统的一部分。
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