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公开(公告)号：US07173016B2
公开(公告)日：2007-02-06
申请号：US11208046
申请日：2005-08-18
CPC分类号： A61K31/7056 , A61K31/7076
摘要： Compositions and methods are provided for prevention and clinical treatment of various forms of graft-versus-host disease (GVHD) by using inhibitors of adenosine deaminase (ADA). In particular, various formulations and dosing regimens of ADA inhibitors such as pentostatin are provided for the treatment of all forms of GVHD, especially steroid-refractory acute and chronic GVHD.
摘要翻译： 提供了通过使用腺苷脱氨酶（ADA）抑制剂预防和临床治疗各种形式的移植物抗宿主病（GVHD）的组合物和方法。 特别地，提供ADA抑制剂例如喷司他丁的各种制剂和给药方案用于治疗所有形式的GVHD，特别是类固醇难治性急性和慢性GVHD。
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公开(公告)号：US07037900B2
公开(公告)日：2006-05-02
申请号：US09976468
申请日：2001-10-12
CPC分类号： A61K31/7056 , A61K31/7076
摘要： Compositions and methods are provided for prevention and clinical treatment of various forms of graft-versus-host disease (GVHD) by using inhibitors of adenosine deaminase (ADA). In particular, various formulations and dosing regimens of ADA inhibitors such as pentostatin are provided for the treatment of humans in vivo as well as for ex vivo conditioning of organ transplants in order to specifically suppress T-lymphocyte mediated immune responses while minimizing systemic toxicity of the drug.
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公开(公告)号：US20060025359A1
公开(公告)日：2006-02-02
申请号：US11208046
申请日：2005-08-18
申请人： Jorge DiMartino , John Nelson
发明人： Jorge DiMartino , John Nelson
IPC分类号： A61K31/7076 , A61K31/7072 , A61K31/7052
CPC分类号： A61K31/7056 , A61K31/7076
摘要： Compositions and methods are provided for prevention and clinical treatment of various forms of graft-versus-host disease (GVHD) by using inhibitors of adenosine deaminase (ADA). In particular, various formulations and dosing regimens of ADA inhibitors such as pentostatin are provided for the treatment of all forms of GVHD, especially steroid-refractory acute and chronic GVHD.
摘要翻译： 提供了通过使用腺苷脱氨酶（ADA）抑制剂预防和临床治疗各种形式的移植物抗宿主病（GVHD）的组合物和方法。 特别地，提供ADA抑制剂例如喷司他丁的各种制剂和给药方案用于治疗所有形式的GVHD，特别是类固醇难治性急性和慢性GVHD。
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4.发明申请Administration Of DNA Methylation Inhibitors For Treating Epigenetic Diseases 审中-公开管理DNA甲基化抑制剂治疗表观遗传病公开(公告)号：US20070105792A1
公开(公告)日：2007-05-10
申请号：US11556080
申请日：2006-11-02
申请人： Jorge DiMartino
发明人： Jorge DiMartino
CPC分类号： A61K31/70
摘要： Methods are provided for treating patients with epigenetic diseases, especially those associated with aberrant DNA methylation such as hematological disorders and cancer. By administering a DNA methylation inhibitor to the patients following unique dosing regimens, the disease can be efficaciously treated with reduced toxic side effects.
摘要翻译： 提供了用于治疗患有表观遗传疾病的方法，特别是与异常DNA甲基化如血液学疾病和癌症有关的那些。 通过以独特的给药方案向患者施用DNA甲基化抑制剂，可以减少毒副作用来有效治疗该疾病。
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5.发明申请Methods for treating hematological disorders through inhibition of DNA methylation and histone deacetylase 有权通过抑制DNA甲基化和组蛋白脱乙酰酶治疗血液病症的方法公开(公告)号：US20050159347A1
公开(公告)日：2005-07-21
申请号：US11082130
申请日：2005-03-15
申请人： Jorge DiMartino
发明人： Jorge DiMartino
IPC分类号： A61K31/335 , A61K45/06 , A61K38/12 , A61K31/165 , A61K31/19 , A61K31/205 , A61K31/7072
CPC分类号： A61K45/06 , A61K31/165 , A61K31/19 , A61K31/205 , A61K31/335 , A61K31/7072 , A61K38/09 , A61K38/12 , A61K38/1816 , A61K38/193 , A61K38/2013 , A61K38/2026 , A61K38/208 , A61K38/212 , A61K38/215 , A61K38/217 , A61K38/31 , A61K2300/00
摘要： Methods are provided for treating hematological disorders by inhibition of DNA hypomethylation and histone deacetylase. Such disorders include, for example, acute promyelocytic leukemia, acute lymphoblastic leukemia, chronic myelogenous leukemia, myelodysplastic syndromes, and sickle cell anemia. The methods comprise: administering to a patient suffering from the disease a therapeutically effective amount of a DNA methylation inhibitor such as a cysteine analog such as decitabine, in combination with an effective amount of histone deacetylase inhibitor such as hydroxamic acid, cyclic peptide, benzamide, butyrate, and depudecin.
摘要翻译： 提供了通过抑制DNA低甲基化和组蛋白脱乙酰酶来治疗血液疾病的方法。 这种疾病包括例如急性早幼粒细胞白血病，急性淋巴细胞性白血病，慢性骨髓性白血病，骨髓增生异常综合征和镰状细胞性贫血。 所述方法包括：给患有该疾病的患者施用治疗有效量的DNA甲基化抑制剂如半胱氨酸类似物如地西他滨，与有效量的组蛋白脱乙酰酶抑制剂如异羟肟酸，环肽，苯甲酰胺， 丁酸酯和去壳蛋白。
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6.发明申请COMPOSITIONS AND METHODS FOR TREATING DISEASES THROUGH INHIBITION OF DNA METHYLATION AND HISTONE DEACETYLASE 审中-公开通过抑制DNA甲基化和HISTONE脱乙酰壳多糖治疗疾病的组合物和方法公开(公告)号：US20080108559A1
公开(公告)日：2008-05-08
申请号：US11844290
申请日：2007-08-23
申请人： Jorge DiMartino
发明人： Jorge DiMartino
IPC分类号： A61K38/12 , A61K31/7072 , A61K31/205 , A61K31/19 , A61K31/165 , A61P35/00
CPC分类号： A61K45/06 , A61K31/165 , A61K31/19 , A61K31/205 , A61K31/335 , A61K31/7072 , A61K38/09 , A61K38/12 , A61K38/1816 , A61K38/193 , A61K38/2013 , A61K38/2026 , A61K38/208 , A61K38/212 , A61K38/215 , A61K38/217 , A61K38/31 , A61K2300/00
摘要： Compositions and methods are provided for treating diseases associated with aberrant silencing of gene expression such as cancer and hematological disorders by reestablishing the gene expression through inhibition of DNA hypomethylation and histone deacetylase. The method comprises: administering to a patient suffering from the disease a therapeutically effective amount of a DNA methylation inhibitor such as a cysteine analog such as decitabine, in combination with an effective amount of histone deacetylase inhibitor such as hydroxamic acid, cyclic peptide, benzamide, butyrate, and depudecin.
摘要翻译： 提供组合物和方法用于通过抑制DNA低甲基化和组蛋白脱乙酰酶重建基因表达来治疗与基因表达异常沉默相关的疾病，例如癌症和血液病症。 该方法包括：给患有该疾病的患者施用治疗有效量的DNA甲基化抑制剂如半胱氨酸类似物如地西他滨，与有效量的组蛋白脱乙酰酶抑制剂如异羟肟酸，环肽，苯甲酰胺， 丁酸酯和去壳蛋白。
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公开(公告)号：US20070066517A1
公开(公告)日：2007-03-22
申请号：US11602192
申请日：2006-11-21
申请人： Jorge DiMartino , John Nelson
发明人： Jorge DiMartino , John Nelson
IPC分类号： A61K38/13 , A61K31/7076 , A61K31/7056 , A61K31/522 , A61K31/573 , A61K31/4745
CPC分类号： A61K31/7056 , A61K31/7076
摘要： Compositions and methods are provided for prevention and clinical treatment of various forms of graft-versus-host disease (GVHD) by using inhibitors of adenosine deaminase (ADA). In particular, various formulations and dosing regimens of ADA inhibitors such as pentostatin are provided for the treatment of all forms of GVHD, especially steroid-refractory acute and chronic GVHD.
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公开(公告)号：US06613753B2
公开(公告)日：2003-09-02
申请号：US09790483
申请日：2001-02-21
申请人： Joseph Rubinfeld , Lucy Chang , Jorge DiMartino
发明人： Joseph Rubinfeld , Lucy Chang , Jorge DiMartino
IPC分类号： A01N4304
CPC分类号： A61K31/495 , A61K31/00 , A61K31/57 , A61K39/39558 , A61K2300/00
摘要： Compositions and methods are provided for treating diseases associated with abnormal cell proliferation such as cancer by storing inherent tumor-suppressing functions of neoplastic cells through DNA hypomethylation. The method comprises: delivering to a patient suffering from cancer a therapeutically effective amount of a DNA methylation inhibitor such as decitabine, in combination with an effective amount of an anti-neoplastic agent whose activity as an anti-neoplastic agent in vivo is adversely affected by aberrant DNA methylation. The anti-neoplastic agent can be an alkylating agent, an antibiotic agent, an antimetabolic agent, a retinoid, a hormonal agent, a plant-derived agent, an anti-angiogenesis agent and a biologic agent such as monoclonal antibody and interferon.
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