公开(公告)号：US20100184081A1

公开(公告)日：2010-07-22

申请号：US12749899

申请日：2010-03-30

申请人： Jose M. Ordovas ,  Lu Qi ,  Andrew Greenberg ,  Dolores Corella

发明人： Jose M. Ordovas ,  Lu Qi ,  Andrew Greenberg ,  Dolores Corella

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6888 ,  C12Q1/6883 ,  C12Q2600/156

摘要： The present invention is directed to new genetic variants or polymorphisms at the perilipin locus (PLIN) including PLIN1: 6209T (allele 1)>C (allele 2); PLIN3 10171 (allele 1) A >T (allele 2); PLIN4: 11482G (allele 1)>A (allele 2); PLIN5: 13041A (allele 1)>G (allele 2) and PLIN6: 14995A (allele 1)>T (allele 2), and their use in diagnostic and prognostic applications for obesity and obesity-related diseases, such as metabolic syndrome and cardiovascular disease.

摘要翻译： 本发明涉及包含PLIN1：6209T（等位基因1）> C（等位基因2）的perilipin基因座（PLIN）的新基因变异或多态性; PLIN3 10171（等位基因1）A> T（等位基因2）; PLIN4：11482G（等位基因1）> A（等位基因2）; T（等位基因1）> G（等位基因2）和PLIN6：14995A（等位基因1）> T（等位基因2），以及它们在诊断和预后应用中用于肥胖和肥胖相关疾病如代谢综合征和心血管 疾病。

公开(公告)号：US20090222282A1

公开(公告)日：2009-09-03

申请号：US12066902

申请日：2006-09-15

申请人： Jose M. Ordovas ,  Dolores Corella

发明人： Jose M. Ordovas ,  Dolores Corella

IPC分类号： G06Q50/00 ,  C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/172 ,  G06Q50/22

摘要： The present invention is directed to methods of developing dietary guidelines, particularly associated with dietary consumption of fatty acids. We discovered an association of a polymorphic marker with regulation of plasma lipid levels in response to dietary intake of polyunsaturated fatty acids. Accordingly, the present invention provides methods for providing individualized guidance in design of dietary interventions to alter plasma lipid profiles by genotyping APOA5 locus, wherein the presence of APOA5−1131C, APOA5−3G, APOA5 IVS3+476A, and APOA5 1259C alleles or alleles that are found to be in tight linkage disequilibrium with APOA5−1131C, APOA5−3G, APOA5 IVS3+476A, and APOA5 1259C alleles, is indicative of the individual being susceptible to altered plasma lipid levels in response to intake of n-6 polyunsaturated fatty acids.

摘要翻译： 本发明涉及制定饮食指南的方法，特别是与脂肪酸的饮食消耗相关。 我们发现多态性标记物与多种不饱和脂肪酸饮食摄入的血浆脂质水平调节有关。 因此，本发明提供了通过基因分型APOA5基因座在膳食干预设计中提供个体化指导以提供血浆脂质谱的方法，其中APOA5-1131C，APOA5-3G，APOA5 IVS3 + 476A和APOA5 1259C等位基因或等位基因的存在 被发现与APOA5-1131C，APOA5-3G，APOA5 IVS3 + 476A和APOA5 1259C等位基因处于紧密连锁不平衡状态，这表明个体对n-6多不饱和脂肪酸摄入的响应易于血浆脂质水平改变 。

公开(公告)号：US20080171335A1

公开(公告)日：2008-07-17

申请号：US11948099

申请日：2007-11-30

申请人： Jose M. Ordovas ,  Dolores Corella ,  Chao-Qiang Lai

发明人： Jose M. Ordovas ,  Dolores Corella ,  Chao-Qiang Lai

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/172

摘要： The invention provides methods and kits for designing a diet with a desired fat content for an individual in need thereof to allow the individual to, for example, maintain or reduce healthy weight, manage diabetes, for example by managing weight or accommodate a food allergy. The method comprises determining whether the individual carries APOA5 −1131T and/or C allele or both or any allele in chromosome 11 that is in a tight linkage disequilibrium with said-alleles, wherein if the individual is a homozygote for APOA5 −1131T allele or an allele in tight linkage disequilibrium with APOA5 −1131T allele, the designing of a diet comprises reducing a total fat content of the diet below 30% of total calorie intake and/or reducing the amount of monounsaturated fatty acids in the diet under about 11% of total calorie intake. We surprisingly found that these methods and kits apply to both females and males and to a variety of ethnic backgrounds.

摘要翻译： 本发明提供了用于为有需要的个体设计具有所需脂肪含量的饮食的方法和试剂盒，以允许个体例如维持或减少健康体重，例如通过控制体重或适应食物过敏来控制糖尿病。 该方法包括确定个体是否携带与所述等位基因处于紧密连锁不平衡中的APOA5 -1131T和/或C等位基因或两者或任何等位基因，其中如果个体是APOA5 -1131T等位基因的纯合子或 等位基因与APOA5 -1131T等位基因紧密连锁不平衡，饮食的设计包括将膳食中总脂肪含量降低至总卡路里摄入量的30％以下，和/或减少饮食中单不饱和脂肪酸的量约11％ 总卡路里摄入量 我们惊奇地发现，这些方法和试剂盒适用于女性和男性以及各种种族背景。

公开(公告)号：US06228581B1

公开(公告)日：2001-05-08

申请号：US09031626

申请日：1998-02-27

申请人： Susan L. Acton ,  Jose M. Ordovas

发明人： Susan L. Acton ,  Jose M. Ordovas

IPC分类号： C12Q168

CPC分类号： C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/172

摘要： The present invention is based at least in part on the discovery of the genomic structure of the human SR-BI gene and on the identification of polymorphic regions within the gene. Accordingly, the invention provides nucleic acids having a nucleotide sequence of an allelic variant of an SR-BI gene and nucleic acids having an SR-BI intronic sequence. The invention also provides methods for identifying specific alleles of polymorphic regions of an SR-BI gene, methods for determining whether a subject has or is at risk of developing a disease which is associated with a specific allele of a polymorphic region of an SR-BI gene, and kits for performing such methods.

摘要翻译： 本发明至少部分地基于人SR-BI基因的基因组结构的发现和基因中多态性区域的鉴定。 因此，本发明提供具有SR-BI基因的等位基因变体的核苷酸序列和具有SR-BI内含子序列的核酸的核酸。 本发明还提供用于鉴定SR-BI基因的多态性区域的特异性等位基因的方法，用于确定受试者是否具有发生与SR-BI的多态性区域的特定等位基因相关的疾病的风险的方法 基因和用于进行这些方法的试剂盒。

公开(公告)号：US20080275728A1

公开(公告)日：2008-11-06

申请号：US12089003

申请日：2006-10-05

申请人： Jose M. Ordovas

发明人： Jose M. Ordovas

IPC分类号： G06Q50/00 ,  C12Q1/68

CPC分类号： C12Q1/6883 ,  A23L33/30 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/16 ,  C12Q2600/172 ,  G06Q50/22

摘要： The present invention provides methods for personalized diet design for females of Asian origin, wherein females who are homozygous for the PLIN 11482A are advised to avoid diets high in fat and low in carbohydrates, to avoid or manage metabolic syndrome and conditions related to metabolic syndrome, such as insulin resistance, diabetes, and cardiovascular disease.

摘要翻译： 本发明提供了用于亚洲女性的个性化饮食设计的方法，其中对于PLIN 11482A是纯合子的女性建议避免高脂肪和低碳水化合物的饮食，以避免或管理与代谢综合征有关的代谢综合征和病症， 如胰岛素抵抗，糖尿病和心血管疾病。

公开(公告)号：US6030778A

公开(公告)日：2000-02-29

申请号：US890979

申请日：1997-07-10

申请人： Susan Laurene Acton ,  Jose M. Ordovas

发明人： Susan Laurene Acton ,  Jose M. Ordovas

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P19/34

CPC分类号： C12Q1/6883 ,  C12Q2600/156

摘要： The present invention is based at least in part on the discovery of a polymorphism in the human SR-BI gene which is genetically linked with a high body mass index. Accordingly, the invention provides diagnostic assays and kits for determining whether a subject has or is at risk of developing an abnormal body mass index, such as a high body mass.

摘要翻译： 本发明至少部分地基于与高体重指数遗传连锁的人SR-BI基因中的多态性的发现。 因此，本发明提供了用于确定受试者是否具有发展异常体重指数（例如高体重）的风险的诊断测定和试剂盒。