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    1,3-disubstituted 4-(aryl-X-phenyl)-1H-pyridin-2-ones
    3.
    发明授权
    1,3-disubstituted 4-(aryl-X-phenyl)-1H-pyridin-2-ones 有权
    1,3-二取代的4-（芳基-N-苯基）-1H-吡啶-2-酮

    公开(公告)号：US08252937B2

    公开(公告)日：2012-08-28

    申请号：US12677691

    申请日：2008-09-12

    申请人： Jose Maria Cid-Nunez ,  Andres Avelino Trabanco-Suarez ,  Gregor James MacDonald ,  Guillaume Albert Jacques Duvey ,  Robert Johannes Lutjens ,  Patrick Terry Finn

    发明人： Jose Maria Cid-Nunez ,  Andres Avelino Trabanco-Suarez ,  Gregor James MacDonald ,  Guillaume Albert Jacques Duvey ,  Robert Johannes Lutjens ,  Patrick Terry Finn

    IPC分类号： C07D211/72 ,  A61K31/44

    CPC分类号： C07D213/64 ,  C07D401/12

    摘要： The present invention relates to novel compounds, in particular novel pyridinone derivatives according to Formula (I) wherein all radicals are as defined in the application and claims. The compounds according to the invention are positive allosteric modulators of metabotropic receptors—subtype 2 (“mGluR2”) which are useful for the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved. In particular, such diseases are central nervous system disorders selected from the group of anxiety, schizophrenia, migraine, depression, and epilepsy. The invention is also directed to pharmaceutical compositions and processes to prepare such compounds and compositions, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR2 is involved.

    摘要翻译： 本发明涉及新化合物，特别是根据式（I）的新型吡啶酮衍生物，其中所有基团如申请和权利要求中所定义。 根据本发明的化合物是代谢型受体亚型2（“mGluR2”）的正性变构调节剂，其可用于治疗或预防与谷氨酸功能障碍相关的神经和精神障碍以及参与代谢型受体的mGluR2亚型的疾病 。 特别地，这些疾病是选自焦虑，精神分裂症，偏头痛，抑郁症和癫痫组的中枢神经系统疾病。 本发明还涉及制备这些化合物和组合物的药物组合物和方法，以及这些化合物用于预防和治疗其中涉及mGluR2的疾病的用途。

    1,3-disubstituted-4-phenyl-1H-pyridin-2-ones
    5.
    发明授权
    1,3-disubstituted-4-phenyl-1H-pyridin-2-ones 有权
    1,3-二取代-4-苯基-1H-吡啶-2-酮

    公开(公告)号：US08722894B2

    公开(公告)日：2014-05-13

    申请号：US12677628

    申请日：2008-09-12

    申请人： Jose Maria Cid-Nunez ,  Andres Avelino Trabanco-Suarez ,  Gregor James MacDonald ,  Guillaume Albert Jacques Duvey ,  Robert Johannes Lutjens ,  Patrick Terry Finn

    发明人： Jose Maria Cid-Nunez ,  Andres Avelino Trabanco-Suarez ,  Gregor James MacDonald ,  Guillaume Albert Jacques Duvey ,  Robert Johannes Lutjens ,  Patrick Terry Finn

    IPC分类号： C07D405/00 ,  A61K31/44

    CPC分类号： C07D405/12 ,  C07D213/64 ,  C07D405/14

    摘要： The present invention relates to novel compounds, in particular novel pyridinone derivatives according to Formula (I) wherein all radicals are as defined in the application and claims. The compounds according to the invention are positive allosteric modulators of metabotropic receptors—subtype 2 (“mGluR2”) which are useful for the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved. In particular, such diseases are central nervous system disorders selected from the group of anxiety, schizophrenia, migraine, depression, and epilepsy. The invention is also directed to pharmaceutical compositions and processes to prepare such compounds and compositions, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR2 is involved.

    摘要翻译： 本发明涉及新化合物，特别是根据式（I）的新型吡啶酮衍生物，其中所有基团如申请和权利要求中所定义。 根据本发明的化合物是代谢型受体亚型2（“mGluR2”）的正性变构调节剂，其可用于治疗或预防与谷氨酸功能障碍相关的神经和精神障碍以及参与代谢型受体的mGluR2亚型的疾病 。 特别地，这些疾病是选自焦虑，精神分裂症，偏头痛，抑郁症和癫痫组的中枢神经系统疾病。 本发明还涉及制备这些化合物和组合物的药物组合物和方法，以及这些化合物用于预防和治疗其中涉及mGluR2的疾病的用途。