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公开(公告)号：US5206269A
公开(公告)日：1993-04-27
申请号：US854227
申请日：1992-03-20
IPC分类号： A61K31/195 , A23L1/305 , A61K31/475 , A61P3/00
CPC分类号： A23L33/175
摘要： The present invention provides a nutritionally useful highly concentrated amino acid solution. In an embodiment, the formulation has a broad amino acid profile that is both high in branched chain amino acids and high in overall percent of amino acids. Additionally, the present invention provides a method of selecting the amino acid profile so as to obtain a maximum amino acid concentration. To this end, a stable amino acid solution having a nutritionally appropriate balance of amino acids comprising a total amino acid concentration equal to or greater than 18% (wt/vol) is provided. In an embodiment, an amino acid solution is provided comprising approximately 18 to about 22% branched chain amino acids (wt/wt); and a total amino acid concentration equal to or greater than 18% (wt/vol).
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公开(公告)号：US06385911B1
公开(公告)日：2002-05-14
申请号：US09021607
申请日：1998-02-10
IPC分类号： E05F1124
CPC分类号： E05F11/16
摘要： An operator for controlling the movement of a window sash relative to a frame with a raised surface along a frame sill thereof, wherein the operator includes a base having a first support surface, an aperture and a bottom exterior surface with a slot therein, the base attached to the frame with the raised surface fitting substantially within the slot. The operator also includes a cover secured to the base and having a second support surface with a hole therethrough defining an internal shoulder, the second support surface mating with the first support surface. A post extends from the cover and through the aperture in the base when the operator is assembled. An arm is pivotally secured to the post and attachable to the sash to control the movement of the sash between open and closed positions. A worm drivably engages the arm and has a worm shaft and a worm shoulder disposed on the worm shaft. The worm is directly supported by the first and second surfaces at one end and the worm shoulder engages the internal shoulder as the worm shaft protruding from the hole.
摘要翻译： 用于控制窗框相对于具有凸起表面的框架的运动沿着其框架的操作器，其中所述操作者包括具有第一支撑表面，孔和底部外表面以及其中的狭槽的底座，所述底座 附接到框架，其中凸起表面基本上配合在槽内。 操作者还包括固定到基座的盖子，并且具有第二支撑表面，第二支撑表面具有穿过其中的孔，所述第二支撑表面限定内部肩部，第二支撑表面与第一支撑表面配合。 当操作员组装时，柱从盖延伸并穿过基座中的孔。 臂被枢转地固定到柱上并且可附接到窗扇以控制窗框在打开位置和关闭位置之间的移动。 蜗杆蜗杆蜗杆蜗杆蜗杆蜗杆蜗杆蜗杆蜗杆蜗杆蜗杆蜗杆蜗杆蜗杆蜗杆蜗杆蜗杆蜗杆蜗杆蜗杆蜗杆蜗杆蜗杆蜗杆蜗杆蜗杆蜗杆蜗杆轴 蜗杆在一端由第一表面和第二表面直接支撑，当蜗杆轴从孔突出时，蜗杆肩与内肩接合。
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公开(公告)号：USD375254S
公开(公告)日：1996-11-05
申请号：US48065
申请日：1995-12-19
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公开(公告)号：US5169864A
公开(公告)日：1992-12-08
申请号：US793043
申请日：1991-11-15
申请人： Douglas G. Johnson , Allan E. Titus
发明人： Douglas G. Johnson , Allan E. Titus
CPC分类号： A61K47/02 , A61K31/34 , A61K47/26 , A61K9/0019
摘要： A pharmaceutical composition is provided comprising an unbuffered iso-osmotic aqueous formulation containing an effective amount of ranitidine for the treatment of conditions mediated through histamine H.sub.2 receptors. The formulation has a pH of greater than or equal to 5.0 and less than 6.5 and preferably includes an osmotic adjusting agent chosen from the group consisting of dextrose and sodium chloride.
摘要翻译： 提供了一种药物组合物，其包含含有有效量的雷尼替丁的无缓冲等渗水性制剂，用于治疗通过组胺H 2受体介导的病症。 制剂具有大于或等于5.0且小于6.5的pH，并且优选包括选自右旋糖和氯化钠的渗透调节剂。
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5.发明授权Compositions of allosteric hemoglobin modifiers and methods of making the same 有权变构血红蛋白修饰剂的组成及其制备方法公开(公告)号：US07847120B2
公开(公告)日：2010-12-07
申请号：US11112389
申请日：2005-04-22
申请人： Al Quick , Antonio M. Santos , Alexandre J G G Carvalho , Douglas G. Johnson , Jeffrey B. Etter , Christopher Murray
发明人： Al Quick , Antonio M. Santos , Alexandre J G G Carvalho , Douglas G. Johnson , Jeffrey B. Etter , Christopher Murray
IPC分类号： C07C229/00 , C07C65/03
CPC分类号： A61K31/195
摘要： The present invention provides novel compositions of allosteric hemoglobin modifiers which are substantially free of impurities, specifically polymeric impurities. In one embodiment, the novel compositions contain an allosteric hemoglobin modifier compound and less than 100 ppm of the polymeric impurities generated during the preparation of this compound. Included in the present invention are novel methods for preparing allosteric hemoglobin modifiers that are substantially free of polymeric impurities. Also included in the present invention are improved methods for the purification of the product formed by the method of this invention. The novel methods of purification comprise extracting the crude composition with a water immiscible or partially immiscible solvent such as methylisobutyl ketone (MIBK) to lower amounts of impurities, specifically polymeric impurities. Also included are methods to reduce impurities by recrystallization of the crude synthesized product, followed by filtration of the recrystallized product. The present invention also includes the products made by the processes of the invention and methods for analyzing compositions comprised of these products.
摘要翻译： 本发明提供基本上不含杂质，特别是聚合物杂质的变构血红蛋白改性剂的新型组合物。 在一个实施方案中，新型组合物含有变构血红蛋白改性剂化合物，并且在制备该化合物期间产生小于100ppm的聚合物杂质。 本发明包括制备基本上不含聚合物杂质的变构型血红蛋白改性剂的新方法。 本发明还包括用于纯化通过本发明方法形成的产品的改进方法。 新颖的纯化方法包括用与水不混溶或部分不混溶的溶剂如甲基异丁基酮（MIBK）提取粗组合物以降低杂质量，特别是聚合物杂质。 还包括通过粗合成产物的重结晶减少杂质的方法，然后过滤重结晶产物。 本发明还包括通过本发明的方法制备的产品和用于分析由这些产品组成的组合物的方法。
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公开(公告)号：US07640672B2
公开(公告)日：2010-01-05
申请号：US12124370
申请日：2008-05-21
CPC分类号： G01C15/105
摘要： The laser reference tool of the invention consists of a base that can be releasably mounted to a surface. A housing is mounted on the base such that it can be repositioned relative to the base in a direction parallel to the surface. A turret carrying the laser module is rotatable about first and second orthogonal axes. The laser module is also rotatable relative to the turret about a third axis orthogonal to the first and second axes.
摘要翻译： 本发明的激光参考工具由可拆卸地安装在表面上的基座构成。 壳体安装在基座上，使得其可以在平行于表面的方向上相对于基座重新定位。 携带激光模块的转台可围绕第一和第二正交轴线旋转。 激光模块也可绕着与第一和第二轴线正交的第三轴线转动。
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公开(公告)号：US5650421A
公开(公告)日：1997-07-22
申请号：US414433
申请日：1995-03-31
申请人： Allan E. Titus , Douglas G. Johnson
发明人： Allan E. Titus , Douglas G. Johnson
IPC分类号： A61K31/426 , A61K31/425
CPC分类号： A61K31/426
摘要： A pharmaceutical composition comprising a solution having an effective amount of famotidine, the solution having a pH in the range of about 4.5 to about 8.0, and a shelf life greater than 30 days.
摘要翻译： 一种药物组合物，其包含具有有效量的法莫替丁的溶液，所述溶液的pH在约4.5至约8.0的范围内，保质期大于30天。
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公开(公告)号：US5765308A
公开(公告)日：1998-06-16
申请号：US575143
申请日：1995-12-19
CPC分类号： E05F11/16
摘要： An operator for controlling the movement of a window sash relative to a frame with a raised surface along a frame sill thereof, wherein the operator includes a base having a first support surface, an aperture and a bottom exterior surface with a slot therein, the base attached to the frame with the raised surface fitting substantially within the slot. The operator also includes a cover secured to the base and having a second support surface with a hole therethrough defining an internal shoulder, the second support surface mating with the first support surface. A post extends from the cover and through the aperture in the base when the operator is assembled. An arm is pivotally secured to the post and attachable to the sash to control the movement of the sash between open and closed positions. A worm driveably engages the arm and has a worm shaft and a worm shoulder disposed on the worm shaft. The worm is directly supported by the first and second surfaces at one end and the worm shoulder engages the internal shoulder as the worm shaft protruding from the hole.
摘要翻译： 用于控制窗框相对于具有凸起表面的框架的运动沿着其框架的操作器，其中所述操作者包括具有第一支撑表面，孔和底部外表面以及其中的狭槽的底座，所述底座 附接到框架，其中凸起表面基本上配合在槽内。 操作者还包括固定到基座的盖子，并且具有第二支撑表面，第二支撑表面具有穿过其中的孔，所述第二支撑表面限定内部肩部，第二支撑表面与第一支撑表面配合。 当操作员组装时，柱从盖延伸并穿过基座中的孔。 臂被枢转地固定到柱上并且可附接到窗扇以控制窗框在打开位置和关闭位置之间的移动。 蜗杆可驱动地与臂接合并且具有设置在蜗杆轴上的蜗杆轴和蜗杆肩。 蜗杆在一端由第一表面和第二表面直接支撑，当蜗杆轴从孔突出时，蜗杆肩与内肩接合。
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公开(公告)号：USD390445S
公开(公告)日：1998-02-10
申请号：US63296
申请日：1996-12-04
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公开(公告)号：USD375674S
公开(公告)日：1996-11-19
申请号：US48061
申请日：1995-12-19
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