公开(公告)号：US07847120B2

公开(公告)日：2010-12-07

申请号：US11112389

申请日：2005-04-22

申请人： Al Quick ,  Antonio M. Santos ,  Alexandre J G G Carvalho ,  Douglas G. Johnson ,  Jeffrey B. Etter ,  Christopher Murray

发明人： Al Quick ,  Antonio M. Santos ,  Alexandre J G G Carvalho ,  Douglas G. Johnson ,  Jeffrey B. Etter ,  Christopher Murray

IPC分类号： C07C229/00 ,  C07C65/03

CPC分类号： A61K31/195

摘要： The present invention provides novel compositions of allosteric hemoglobin modifiers which are substantially free of impurities, specifically polymeric impurities. In one embodiment, the novel compositions contain an allosteric hemoglobin modifier compound and less than 100 ppm of the polymeric impurities generated during the preparation of this compound. Included in the present invention are novel methods for preparing allosteric hemoglobin modifiers that are substantially free of polymeric impurities. Also included in the present invention are improved methods for the purification of the product formed by the method of this invention. The novel methods of purification comprise extracting the crude composition with a water immiscible or partially immiscible solvent such as methylisobutyl ketone (MIBK) to lower amounts of impurities, specifically polymeric impurities. Also included are methods to reduce impurities by recrystallization of the crude synthesized product, followed by filtration of the recrystallized product. The present invention also includes the products made by the processes of the invention and methods for analyzing compositions comprised of these products.

摘要翻译： 本发明提供基本上不含杂质，特别是聚合物杂质的变构血红蛋白改性剂的新型组合物。 在一个实施方案中，新型组合物含有变构血红蛋白改性剂化合物，并且在制备该化合物期间产生小于100ppm的聚合物杂质。 本发明包括制备基本上不含聚合物杂质的变构型血红蛋白改性剂的新方法。 本发明还包括用于纯化通过本发明方法形成的产品的改进方法。 新颖的纯化方法包括用与水不混溶或部分不混溶的溶剂如甲基异丁基酮（MIBK）提取粗组合物以降低杂质量，特别是聚合物杂质。 还包括通过粗合成产物的重结晶减少杂质的方法，然后过滤重结晶产物。 本发明还包括通过本发明的方法制备的产品和用于分析由这些产品组成的组合物的方法。

公开(公告)号：US10106437B2

公开(公告)日：2018-10-23

申请号：US13177826

申请日：2011-07-07

申请人： Gautam Khanna ,  Al Quick

发明人： Mark T. Hernandez ,  Muna Abu-Dalo ,  Gautam Khanna ,  Al Quick

IPC分类号： C02F1/28 ,  B01J20/20 ,  B01J20/32 ,  C02F101/20 ,  C02F103/10 ,  C02F103/16 ,  C02F103/24 ,  C02F103/30

摘要： A metal removal system and method are disclosed. An example method includes providing a sorptive media and providing a primary ligand having an affinity for the sorptive media, the primary ligand being an amphipathic, heterocyclic metal-coordinating compound. The method also includes providing a co-ligand having an affinity for the sorptive media. During a treatment process, a metal removal response is observed to be non-proportional between expected metal removal ability based on individual metal coordination abilities of the media alone and of all ligands, and actual net metal removal capacity resulting from a heterogeneous cooperation of the primary ligand and the sorptive media and activated by the co-ligand.

公开(公告)号：US20070293698A1

公开(公告)日：2007-12-20

申请号：US10598874

申请日：2005-04-22

申请人： Al Quick ,  Antonio Santos ,  Alexandre J.G. Carvalho ,  Douglas Johnson ,  Jeffrey Etter ,  Chris Murray

发明人： Al Quick ,  Antonio Santos ,  Alexandre J.G. Carvalho ,  Douglas Johnson ,  Jeffrey Etter ,  Chris Murray

IPC分类号： C07C233/01 ,  C07C231/00 ,  G01N30/00 ,  C07C233/00

CPC分类号： A61K31/195

摘要： The present invention provides novel compositions of allosteric hemoglobin modifiers which are substantially free of impurities, specifically polymeric impurities. In one embodiment, the novel compositions contain an allosteric hemoglobin modifier compound and less than 100 ppm of the polymeric impurities generated during the preparation of this compound. Included in the present invention are novel methods for preparing allosteric hemoglobin modifiers that are substantially free of polymeric impurities. Also included in the present invention are improved methods for the purification of the product formed by the method of this invention. The novel methods of purification comprise extracting the crude composition with a water immiscible or partially immiscible solvent such as methylisobutyl ketone (MIBK) to lower amounts of impurities, specifically polymeric impurities. Also included are methods to reduce impurities by recrystallization of the crude synthesized product, followed by filtration of the recrystallized product. The present invention also includes the products made by the processes of the invention and methods for analyzing compositions comprised of these products.

摘要翻译： 本发明提供基本上不含杂质，特别是聚合物杂质的变构血红蛋白改性剂的新型组合物。 在一个实施方案中，新型组合物含有变构血红蛋白改性剂化合物，并且在制备该化合物期间产生小于100ppm的聚合物杂质。 本发明包括制备基本上不含聚合物杂质的变构型血红蛋白改性剂的新方法。 本发明还包括用于纯化通过本发明方法形成的产品的改进方法。 新颖的纯化方法包括用与水不混溶或部分不混溶的溶剂如甲基异丁基酮（MIBK）提取粗组合物以降低杂质量，特别是聚合物杂质。 还包括通过粗合成产物的重结晶减少杂质的方法，然后过滤重结晶产物。 本发明还包括通过本发明的方法制备的产品和用于分析由这些产品组成的组合物的方法。

公开(公告)号：US20050239893A1

公开(公告)日：2005-10-27

申请号：US11112389

申请日：2005-04-22

申请人： Al Quick ,  Antonio Santos ,  Alexandre Carvalho ,  Douglas Johnson ,  Jeffrey Etter ,  Christopher Murray

发明人： Al Quick ,  Antonio Santos ,  Alexandre Carvalho ,  Douglas Johnson ,  Jeffrey Etter ,  Christopher Murray

IPC分类号： A61K31/195

CPC分类号： A61K31/195

摘要： The present invention provides novel compositions of allosteric hemoglobin modifiers which are substantially free of impurities, specifically polymeric impurities. In one embodiment, the novel compositions contain an allosteric hemoglobin modifier compound and less than 100 ppm of the polymeric impurities generated during the preparation of this compound. Included in the present invention are novel methods for preparing allosteric hemoglobin modifiers that are substantially free of polymeric impurities. Also included in the present invention are improved methods for the purification of the product formed by the method of this invention. The novel methods of purification comprise extracting the crude composition with a water immiscible or partially immiscible solvent such as methylisobutyl ketone (MIBK) to lower amounts of impurities, specifically polymeric impurities. Also included are methods to reduce impurities by recrystallization of the crude synthesized product, followed by filtration of the recrystallized product. The present invention also includes the products made by the processes of the invention and methods for analyzing compositions comprised of these products.

摘要翻译： 本发明提供基本上不含杂质，特别是聚合物杂质的变构血红蛋白改性剂的新型组合物。 在一个实施方案中，新型组合物含有变构血红蛋白改性剂化合物，并且在制备该化合物期间产生小于100ppm的聚合物杂质。 本发明包括制备基本上不含聚合物杂质的变构型血红蛋白改性剂的新方法。 本发明还包括用于纯化通过本发明方法形成的产品的改进方法。 新的纯化方法包括用与水不混溶或部分不混溶的溶剂如甲基异丁基酮（MIBK）萃取粗组合物以降低杂质量，特别是聚合物杂质。 还包括通过粗合成产物的重结晶减少杂质的方法，然后过滤重结晶产物。 本发明还包括通过本发明的方法制备的产品和用于分析由这些产品组成的组合物的方法。

公开(公告)号：US20130001169A1

公开(公告)日：2013-01-03

申请号：US13177826

申请日：2011-07-07

申请人： Mark T. Hernandez ,  Muna Abu Dalo ,  Gautam Khanna ,  Al Quick

发明人： Mark T. Hernandez ,  Muna Abu Dalo ,  Gautam Khanna ,  Al Quick

IPC分类号： B01J20/22 ,  C02F1/28 ,  C02F101/20

CPC分类号： C02F1/288 ,  B01J20/20 ,  B01J20/3204 ,  B01J20/3248 ,  B01J20/3255 ,  B01J20/3285 ,  C02F1/283 ,  C02F1/285 ,  C02F2101/20 ,  C02F2103/10 ,  C02F2103/16 ,  C02F2103/24 ,  C02F2103/30 ,  C02F2209/06 ,  C02F2303/16

摘要： A metal removal system and method are disclosed. An example method includes providing a sorptive media and providing a primary ligand having an affinity for the sorptive media, the primary ligand being an amphipathic, heterocyclic metal-coordinating compound. The method also includes providing a co-ligand having an affinity for the sorptive media. During a treatment process, a metal removal response is observed to be non-proportional between expected metal removal ability based on individual metal coordination abilities of the media alone and of all ligands, and actual net metal removal capacity resulting from a heterogeneous cooperation of the primary ligand and the sorptive media and activated by the co-ligand.

摘要翻译： 公开了一种金属去除系统和方法。 示例性方法包括提供吸附介质并提供对吸附介质具有亲和力的主配体，所述主配体是两亲性杂环金属配位化合物。 该方法还包括提供对吸附介质具有亲和性的共配位体。 在处理过程中，金属去除响应被观察到与基于单独的介质和所有配体的单独的金属配位能力的期望的金属去除能力之间成比例，以及由主要的非均相配合产生的实际的净金属去除能力 配体和吸附介质，并由共配体活化。