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1.发明授权公开(公告)号：US08512717B2
公开(公告)日：2013-08-20
申请号：US10911966
申请日：2004-08-05
申请人： Joseph G. Vehige , James N. Chang , Richard Graham , Robert T. Lyons , Teresa H. Kuan , Chin-Ming Chang
发明人： Joseph G. Vehige , James N. Chang , Richard Graham , Robert T. Lyons , Teresa H. Kuan , Chin-Ming Chang
CPC分类号： A61K31/407 , A61K9/0048 , A61K31/00 , A61K47/38
摘要： The present invention provides for compositions for administering a therapeutically effective amount of a therapeutic component. The compositions may include an ophthalmically acceptable carrier component; a therapeutically effective amount of a therapeutic component; and a retention component which may be effective to reduce wettability, induce viscosity, increase muco-adhesion, increase meniscus height on a cornea of an eye and/or increase physical apposition to a cornea of an eye of a composition.
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2.发明授权Ophthalmic compositions for lubricating eyes and methods for making and using same 有权用于润滑眼睛的眼用组合物及其制造和使用方法公开(公告)号：US07045121B2
公开(公告)日：2006-05-16
申请号：US10017817
申请日：2001-12-14
申请人： James N. Chang , Teresa H. Kuan
发明人： James N. Chang , Teresa H. Kuan
IPC分类号： A61K31/47
CPC分类号： A61K9/0048 , A61K47/38 , Y10S514/912
摘要： Ophthalmic compositions include an ophthalmically acceptable carrier component, for example, an aqueous-based carrier, and a plurality of polyanionic component portions having different molecular weights. In one embodiment, the polyanionic component includes a first polyanionic component portion having a first molecular weight; and a second polyanionic component portion having a different second molecular weight. Each of the first and second polyanionic component portions is present in an amount effective to provide lubrication to an eye when the composition is administered to an eye. Methods of making and using such compositions are also disclosed.
摘要翻译： 眼科组合物包括眼用可接受的载体组分，例如水性载体，以及具有不同分子量的多个聚阴离子组分部分。 在一个实施方案中，聚阴离子组分包括具有第一分子量的第一聚阴离子组分部分; 和具有不同第二分子量的第二聚阴离子组分部分。 当将组合物施用于眼睛时，第一和第二聚阴离子组分部分中的每一个以有效地向眼睛提供润滑的量存在。 还公开了制备和使用这些组合物的方法。
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公开(公告)号：US20120142783A1
公开(公告)日：2012-06-07
申请号：US13370574
申请日：2012-02-10
IPC分类号： A61K31/165 , A61P27/02 , A61P27/06
CPC分类号： A61K31/5575 , A01N33/12 , A61K9/0048 , A61K31/14 , A61K31/165 , A61K31/557 , A61K47/02 , A61K47/12
摘要： A composition comprising from 0.005% to 0.02% bimatoprost by weight and from 100 ppm to 250 ppm benzalkonium chloride, wherein said composition is an aqueous liquid which is formulated for ophthalmic administration is disclosed herein.A method which is useful in treating glaucoma or ocular hypertension related thereto is also disclosed herein.
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公开(公告)号：US20120316243A1
公开(公告)日：2012-12-13
申请号：US13551362
申请日：2012-07-17
CPC分类号： A61K31/5575 , A61K9/0048 , A61K9/08 , A61K31/14 , A61K31/164 , A61K31/165 , A61K47/02 , A61K47/183 , A61K47/186 , A61K2300/00
摘要： A composition comprising from 0.005% to 0.02% bimatoprost by weight and from 100 ppm to 250 ppm benzalkonium chloride, wherein said composition is an aqueous liquid which is formulated for ophthalmic administration is disclosed herein. A method which is useful in treating glaucoma or ocular hypertension related thereto is also disclosed herein.
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公开(公告)号：US20090149546A1
公开(公告)日：2009-06-11
申请号：US12351383
申请日：2009-01-09
IPC分类号： A61K31/165
CPC分类号： A61K31/5575 , A01N33/12 , A61K9/0048 , A61K31/14 , A61K31/165 , A61K31/557 , A61K47/02 , A61K47/12
摘要： A composition comprising from 0.005% to 0.02% bimatoprost by weight and from 100 ppm to 250 ppm benzalkonium chloride, wherein said composition is an aqueous liquid which is formulated for ophthalmic administration is disclosed herein.A method which is useful in treating glaucoma or ocular hypertension related thereto is also disclosed herein.
摘要翻译： 本文公开了包含0.005％至0.02％的比马前列素和100ppm至250ppm苯扎氯铵的组合物，其中所述组合物是配制用于眼部给药的水性液体。 本文还公开了可用于治疗与其有关的青光眼或高眼压症的方法。
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公开(公告)号：US20070202187A1
公开(公告)日：2007-08-30
申请号：US11676577
申请日：2007-02-20
申请人： Chin-Ming Chang , James N. Chang , E. Quinn Farnes
发明人： Chin-Ming Chang , James N. Chang , E. Quinn Farnes
IPC分类号： A61K9/16
CPC分类号： A61K9/1676 , A61K9/4808 , A61K9/5078
摘要： Dosage forms comprising therapeutically active compounds are disclosed herein.
摘要翻译： 本文公开了包含治疗活性化合物的剂型。
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公开(公告)号：US08933127B2
公开(公告)日：2015-01-13
申请号：US13551362
申请日：2012-07-17
IPC分类号： A61K31/16 , A61K31/164 , A61K9/00 , A61K9/08 , A61K31/14 , A61K31/5575 , A61K47/18 , A61K31/165
CPC分类号： A61K31/5575 , A61K9/0048 , A61K9/08 , A61K31/14 , A61K31/164 , A61K31/165 , A61K47/02 , A61K47/183 , A61K47/186 , A61K2300/00
摘要： A composition comprising from 0.005% to 0.02% bimatoprost by weight and from 100 ppm to 250 ppm benzalkonium chloride, wherein said composition is an aqueous liquid which is formulated for ophthalmic administration is disclosed herein. A method which is useful in treating glaucoma or ocular hypertension related thereto is also disclosed herein.
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公开(公告)号：US20130079414A1
公开(公告)日：2013-03-28
申请号：US13254543
申请日：2010-03-04
IPC分类号： A61K31/165
CPC分类号： A61K31/5575 , A61K9/0048 , A61K9/08 , A61K31/14 , A61K31/164 , A61K31/165 , A61K47/02 , A61K47/183 , A61K47/186 , A61K2300/00
摘要： A composition comprising from 0.005% to 0.02% bimatoprost by weight and from 100 ppm to 250 ppm benzalkonium chloride, wherein said composition is an aqueous liquid which is formulated for ophthalmic administration is disclosed herein. A method which is useful in treating glaucoma or ocular hypertension related thereto is also disclosed herein.
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公开(公告)号：US20120289603A1
公开(公告)日：2012-11-15
申请号：US13551379
申请日：2012-07-17
IPC分类号： A61K31/165 , A61P27/06 , A61P27/02
CPC分类号： A61K31/5575 , A61K9/0048 , A61K9/08 , A61K31/14 , A61K31/164 , A61K31/165 , A61K47/02 , A61K47/183 , A61K47/186 , A61K2300/00
摘要： A composition comprising from 0.005% to 0.02% bimatoprost by weight and from 100 ppm to 250 ppm benzalkonium chloride, wherein said composition is an aqueous liquid which is formulated for ophthalmic administration is disclosed herein. A method which is useful in treating glaucoma or ocular hypertension related thereto is also disclosed herein.
摘要翻译： 本文公开了包含0.005％至0.02％的比马前列素和100ppm至250ppm苯扎氯铵的组合物，其中所述组合物是配制用于眼部给药的水性液体。 本文还公开了可用于治疗与其有关的青光眼或高眼压症的方法。
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公开(公告)号：US08278353B2
公开(公告)日：2012-10-02
申请号：US13370574
申请日：2012-02-10
IPC分类号： A61K31/19 , A61K31/215
CPC分类号： A61K31/5575 , A01N33/12 , A61K9/0048 , A61K31/14 , A61K31/165 , A61K31/557 , A61K47/02 , A61K47/12
摘要： A composition comprising from 0.005% to 0.02% bimatoprost by weight and from 100 ppm to 250 ppm benzalkonium chloride, wherein said composition is an aqueous liquid which is formulated for ophthalmic administration is disclosed herein.
摘要翻译： 本文公开了包含0.005％至0.02％的比马前列素和100ppm至250ppm苯扎氯铵的组合物，其中所述组合物是配制用于眼部给药的水性液体。
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