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公开(公告)号:US20200062768A1
公开(公告)日:2020-02-27
申请号:US16610450
申请日:2018-05-01
申请人: Joseph M. SALVINO , Xin FENG , Alessandro FATATIS , Fei SHEN , Olimpia MEUCCI
发明人: Joseph M. SALVINO , Xin FENG , Alessandro FATATIS , Fei SHEN , Olimpia MEUCCI
IPC分类号: C07D487/04 , C07D519/00 , A61P35/00
摘要: The invention provides compounds that are fractalkine receptor agonists and useful in treating, preventing or minimizing metastasis in a subject diagnosed with cancer. The compounds of the invention are further useful in treating central nervous system diseases (such as, but not limited to, HIV Associated Neurocognitive Disorders (HAND), and/or Alzheimer's disease), pain, inflammation (such as, but not limited to, arthritis), cardiovascular disease (such as, but not limited to, undesired vascular smooth muscle proliferation, atherosclerosis, coronary vascular endothelial dysfunction, and/or coronary artery disease), and/or multiple sclerosis.