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公开(公告)号:US06793437B2
公开(公告)日:2004-09-21
申请号:US10235526
申请日:2002-09-05
申请人: Joseph P. Kitko , Michael C. Wolf
发明人: Joseph P. Kitko , Michael C. Wolf
IPC分类号: E01C1923
CPC分类号: E01C19/285
摘要: A compaction roller particularly useful for vibration compaction of the shoulder area of roadways. The compactor is designed as an attachment for side-mounting to self-propelled or motorized machinery (e.g. a skid steer front loader). The compaction roller contains: (a) a front section comprising a frame connected to a front cylindrical roller; (b) a rear section comprising a frame connected to a rear cylindrical roller; (c) a joining means pivotally connecting said front and rear sections; and (d) a means for attaching to a self-propelled machinery in a side-mounted fashion. The pivoting compactor allows for simultaneous pinching and compacting on two different planes and reduces the hazards of operating a road roller compactor directly on a sloped surface.
摘要翻译: 特别适用于巷道肩部区域振动压实的压实辊。 压实机被设计为用于侧向安装到自推进或机动的机械(例如滑移转向前装载机)的附件。 压实辊包括:(a)前部,包括连接到前圆柱滚子的框架; (b)后部,包括连接到后圆柱滚子的框架; (c)可枢转地连接所述前部和后部的接合装置; 和(d)用于以侧面安装的方式附接到自走式机械的装置。 旋转压实机允许在两个不同的平面上同时进行夹紧和压实,并减少直接在倾斜表面上操作压路机的危险。
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公开(公告)号:US09139575B2
公开(公告)日:2015-09-22
申请号:US13640732
申请日:2011-04-13
申请人: Benhur Lee , Michael E. Jung , Jihye Lee , Frederic Vigant , Peter J. Bradley , Michael C. Wolf , Bettina E. Hajagos
发明人: Benhur Lee , Michael E. Jung , Jihye Lee , Frederic Vigant , Peter J. Bradley , Michael C. Wolf , Bettina E. Hajagos
IPC分类号: C07D417/06 , C07D405/06 , C07D413/06
CPC分类号: C07D413/06 , A61K9/0014 , A61K9/127 , C07D405/06
摘要: The invention provides compounds represented by the formulae: (I) and (II) where the compounds are useful in treating, for example, viral and/or parasitic infections. Also provided are pharmaceutical compositions comprising the compounds and methods of treatment using the compounds.
摘要翻译: 本发明提供了由式(I)和(II)表示的化合物,其中化合物可用于治疗例如病毒和/或寄生虫感染。 还提供了包含该化合物的药物组合物和使用该化合物的治疗方法。
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公开(公告)号:US20120219613A1
公开(公告)日:2012-08-30
申请号:US13000310
申请日:2009-06-18
申请人: Benhur Lee , Michael E. Jung , Michael C. Wolf , Tinghu Zhang
发明人: Benhur Lee , Michael E. Jung , Michael C. Wolf , Tinghu Zhang
IPC分类号: A61K31/427 , A61P31/18 , C07D495/04 , A61P31/16 , A61K9/127 , C07D417/06 , A61P31/14 , A61P31/22
CPC分类号: C07D417/06 , A61K31/427 , C07D495/04 , Y02A50/385 , Y02A50/387 , Y02A50/393 , Y02A50/397
摘要: Provided herein are a series of arylmethylidene rhodanine derivatives having broad-spectrum antiviral activity against enveloped viruses, including but not limited to filoviruses, poxviruses, arenaviruses, bunyaviruses, paramyxoviruses, flaviviruses, influenza A, and HIV-1. The compounds act via a novel mechanism to disrupt viral membranes and inhibit viral attachment, fusion, and/or entry into host cells. The membrane disrupting activity of the compounds is selective for viral membranes relative to other biological membranes, making the compounds non-toxic to cells and host subjects.
摘要翻译: 本文提供了一系列具有针对包膜病毒的广谱抗病毒活性的芳基亚甲基绕丹宁衍生物,包括但不限于叶病毒,痘病毒,氨基葡萄病毒,布尼瓦病毒,副粘病毒,黄病毒,甲型流感和HIV-1。 化合物通过新的机制起作用以破坏病毒膜并抑制病毒附着,融合和/或进入宿主细胞。 化合物的膜破坏活性相对于其他生物膜对病毒膜是选择性的,使得化合物对细胞和宿主受试者无毒。
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公开(公告)号:US20170021254A1
公开(公告)日:2017-01-26
申请号:US15189443
申请日:2016-06-22
申请人: Michael C. Wolf
发明人: Michael C. Wolf
IPC分类号: A63B67/06
CPC分类号: A63B67/06 , A63B2067/063 , A63B2210/50
摘要: A TRIPLE-PLAY game and a FIRST-N-TEN game are provided that can be readily assembled and disassemble by the player and can be played indoors or outdoors. Each of the games includes identical base units. The TRIPLE-PLAY game has first second and third upright posts of varying lengths that are supported by cross arms and base unit. Players score points by throwing rings over the upright posts. The FIRST-N-TEN game is similar and has first and second goal posts that players throw rings at in order to ring the goal posts or deflect to ring the goal posts. Each game provides for hours of exciting and competitive game play. The games have rules that further enhance the entertainment the players experience while playing. The TRIPLE-PLAY game and the first and the FIRST-N-TEN games can be stored in a bag when disassembled.
摘要翻译: 提供了三重播放游戏和第十一N-TEN游戏,可以由玩家轻松组装和拆卸,并可在室内或室外玩。 每个游戏包括相同的基本单位。 TRIPLE-PLAY游戏具有由交叉臂和基座单元支撑的不同长度的第一和第三直立柱。 玩家通过在直立柱上投掷戒指来得分。 第一场N-TEN游戏是类似的,并且具有第一和第二个目标职位,玩家抛出戒指以敲击目标杆或偏转球门柱。 每场比赛提供了数小时的激动人心和有竞争力的游戏。 游戏具有进一步增强玩家在玩耍时体验的娱乐的规则。 三人游戏游戏和第一和第十一N-TEN游戏可以在拆卸时存储在包中。
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公开(公告)号:US20130028966A1
公开(公告)日:2013-01-31
申请号:US13640732
申请日:2011-04-13
申请人: Benhur Lee , Michael E. Jung , Jihye Lee , Frederic Vigant , Peter J. Bradley , Michael C. Wolf , Bettina E. Hajagos
发明人: Benhur Lee , Michael E. Jung , Jihye Lee , Frederic Vigant , Peter J. Bradley , Michael C. Wolf , Bettina E. Hajagos
IPC分类号: A61K31/429 , A61K31/422 , A61K31/4178 , C07D417/06 , A61P31/22 , C07D405/06 , A61P31/12 , A61P31/18 , A61P33/00 , A61P31/14 , A61K9/127 , C07D413/06
CPC分类号: C07D413/06 , A61K9/0014 , A61K9/127 , C07D405/06
摘要: The invention provides compounds represented by the formulae: (I) and (II) where the compounds are useful in treating, for example, viral and/or parasitic infections. Also provided are pharmaceutical compositions comprising the compounds and methods of treatment using the compounds.
摘要翻译: 本发明提供了由式(I)和(II)表示的化合物,其中化合物可用于治疗例如病毒和/或寄生虫感染。 还提供了包含该化合物的药物组合物和使用该化合物的治疗方法。
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