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    Automated extraction and purification of samples using optical tweezers
    1.
    发明申请
    Automated extraction and purification of samples using optical tweezers 失效
    使用光学镊子自动提取和纯化样品

    公开(公告)号：US20060134603A1

    公开(公告)日：2006-06-22

    申请号：US11298565

    申请日：2005-12-12

    申请人： Joseph Plewa ,  Evan Tanner ,  Daniel Mueth ,  Crystal Duke ,  Kevin Ehrenreich

    发明人： Joseph Plewa ,  Evan Tanner ,  Daniel Mueth ,  Crystal Duke ,  Kevin Ehrenreich

    IPC分类号： C12Q1/00

    CPC分类号： G02B21/32 ,  B01L3/502761 ,  G01N1/34 ,  G01N15/1463 ,  G01N2001/007 ,  G01N2015/1454 ,  G01N2015/149 ,  G02B5/32 ,  Y10T436/25375

    摘要： An apparatus and method for purifying a forensic sample using an automated extraction and purification system includes optical tweezers; an input channel through which the sample is introduced; a chamber which receives the sample from the input channel; a collection channel through which selected particles of the sample are removed; and an output through which unselected particles of the sample are removed. At least one buffer input channel is provided. The input channel may allow sedimentation of the sample into the chamber by gravity. In another arrangement, the system includes an optical trapping system; a first channel through which the sample is introduced; a second channel through which buffer is introduced; wherein the optical tweezers are used to move selected particles of the sample from the first channel to the second channel. The selected particles may be sperm. The optical tweezers preferably utilize holographic optical trapping.

    摘要翻译： 使用自动提取和净化系统来净化法医样品的装置和方法包括光学镊子; 导入样品的输入通道; 从输入通道接收样品的室; 取出样品的所选粒子的收集通道; 以及去除样品的未选择的颗粒的输出。 提供至少一个缓冲器输入通道。 输入通道可以允许样品通过重力沉降到室中。 在另一种布置中，该系统包括光学捕获系统; 引入样品的第一通道; 引入缓冲液的第二通道; 其中所述光学镊子用于将所述样品的选定颗粒从所述第一通道移动到所述第二通道。 所选择的颗粒可能是精子。 光学镊子优选利用全息光学捕获。

    Method and device for manipulation of an intraocular lens
    3.
    发明申请
    Method and device for manipulation of an intraocular lens 失效
    用于操纵眼内透镜的方法和装置

    公开(公告)号：US20050277944A1

    公开(公告)日：2005-12-15

    申请号：US10622988

    申请日：2003-07-18

    申请人： John Kappelhof ,  Jos Loobergen ,  Jon Taylor ,  Kevin Ehrenreich ,  Robert Kershner

    发明人： John Kappelhof ,  Jos Loobergen ,  Jon Taylor ,  Kevin Ehrenreich ,  Robert Kershner

    IPC分类号： A61F2/16 ,  A61F9/00

    CPC分类号： A61F2/1613 ,  A61F2/1662 ,  A61F2/1664 ,  A61F2/1691 ,  A61F2002/1683

    摘要： A method for charging a deformable intraocular lens into a receptacle through a slit or opening in the receptacle periphery, the lens in un-deformed state comprising a) a roughly disc shaped optic part configured to act as a lens when inserted into an eye and b) at least two elongated haptic legs, each leg having an inner end attached to the optic part, an outer end being free and intermediate points in between the inner end and the free end, each leg being curved in unstressed state and being flexible to at least a less curved configuration under stress. The method comprises the steps of i) stretching the legs to align the legs along a substantially straight line, ii) aligning or maintaining the substantially straight line over and substantially parallel with the slit or opening of the receptacle, and iii) transferring at least the two legs through the slit or opening into the receptacle. A device for stretching the haptics of a lens comprises i) at least two haptic guiding surfaces arranged for each of the at least two haptic legs, the guiding surfaces having less curvature than the legs in un-stressed state, ii) a seat for the lens arranged with respect to the guiding surfaces so as to allow, when a lens is positioned in the seat, contact between a first point on the leg and its guiding structure and iii) a lens guiding arrangement allowing the lens to be moved along a path bringing at least a second point on the leg into contact with, or closer to, its guiding structure or a transfer opening allowing passage of the lens with the haptics, having said less curvature, to a receptacle.

    摘要翻译： 一种用于将可变形眼内透镜通过插座周边的狭缝或开口装入插座的方法，所述透镜处于未变形状态，包括：a）大致圆盘形的光学部件，被构造成当插入眼睛时用作透镜，b ）至少两个细长的触觉腿，每个腿具有附接到光学部分的内端，外端是自由的，并且在内端和自由端之间的中间点，每个腿在无应力状态下弯曲并且柔性到 在应力下至少有一个较不弯曲的构型。 该方法包括以下步骤：i）使腿部沿着基本上直线对准腿部，ii）将基本直线对准或保持在插座的狭缝或开口上方并基本平行，以及iii）将至少 两条腿穿过狭缝或开口进入容器。 用于拉伸透镜的触觉的装置包括：i）为至少两个触觉腿中的每一个布置的至少两个触觉引导表面，所述引导表面在不受应力状态下具有比所述腿少的曲率，ii） 相对于引导表面布置的透镜，以便当透镜定位在座中时，在腿上的第一点与其引导结构之间接触，以及iii）允许透镜沿着路径移动的透镜引导装置 使腿上的至少第二点与其引导结构接触或更接近，或者更接近其导向结构或允许具有较小曲率的具有较小曲率的触觉件将透镜通过到容器的传送开口。

    Method and Device for Manipulation of an Intraocular lens
    5.
    发明申请
    Method and Device for Manipulation of an Intraocular lens 有权
    人工晶状体操作的方法和装置

    公开(公告)号：US20080065096A1

    公开(公告)日：2008-03-13

    申请号：US11939860

    申请日：2007-11-14

    申请人： John Kappelhof ,  Jos Loobergen ,  Jon Taylor ,  Kevin Ehrenreich ,  Robert Kershner

    发明人： John Kappelhof ,  Jos Loobergen ,  Jon Taylor ,  Kevin Ehrenreich ,  Robert Kershner

    IPC分类号： A61F9/007

    CPC分类号： A61F2/1613 ,  A61F2/1662 ,  A61F2/1664 ,  A61F2/1691 ,  A61F2002/1683

    摘要： A method for charging a deformable intraocular lens into a receptacle through a slit or opening in the receptacle periphery, the lens in un-deformed state comprising a) a roughly disc shaped optic part configured to act as a lens when inserted into an eye and b) at least two elongated haptic legs, each leg having an inner end attached to the optic part, an outer end being free and intermediate points in between the inner end and the free end, each leg being curved in unstressed state and being flexible to at least a less curved configuration under stress. The method comprises the steps of i) stretching the legs to align the legs along a substantially straight line, ii) aligning or maintaining the substantially straight line over and substantially parallel with the slit or opening of the receptacle, and iii) transferring at least the two legs through the slit or opening into the receptacle. A device for stretching the haptics of a lens comprises i) at least two haptic guiding surfaces arranged for each of the at least two haptic legs, the guiding surfaces having less curvature than the legs in un-stressed state, ii) a seat for the lens arranged with respect to the guiding surfaces so as to allow, when a lens is positioned in the seat, contact between a first point on the leg and its guiding structure and iii) a lens guiding arrangement allowing the lens to be moved along a path bringing at least a second point on the leg into contact with, or closer to, its guiding structure or a transfer opening allowing passage of the lens with the haptics, having said less curvature, to a receptacle.

    摘要翻译： 一种用于将可变形眼内透镜通过插座周边的狭缝或开口装入插座的方法，所述透镜处于未变形状态，包括：a）大致圆盘形的光学部件，被构造成当插入眼睛时用作透镜，b ）至少两个细长的触觉腿，每个腿具有附接到光学部分的内端，外端是自由的，并且在内端和自由端之间的中间点，每个腿在无应力状态下弯曲并且柔性到 在应力下至少有一个较不弯曲的构型。 该方法包括以下步骤：i）使腿部沿着基本上直线对准腿部，ii）将基本直线对准或保持在插座的狭缝或开口上方并基本平行，以及iii）将至少 两条腿穿过狭缝或开口进入容器。 用于拉伸透镜的触觉的装置包括：i）为至少两个触觉腿中的每一个布置的至少两个触觉引导表面，所述引导表面在不受应力状态下具有比所述腿少的曲率，ii） 相对于引导表面布置的透镜，以便当透镜定位在座中时，在腿上的第一点与其引导结构之间接触，以及iii）允许透镜沿着路径移动的透镜引导装置 使腿上的至少第二点与其引导结构接触或更接近，或者更接近其导向结构或允许具有较小曲率的具有较小曲率的触觉件将透镜通过到容器的传送开口。