公开(公告)号：US20060153932A1

公开(公告)日：2006-07-13

申请号：US11191600

申请日：2005-07-27

申请人： Josephine Ferdinando ,  David Gilmour

发明人： Josephine Ferdinando ,  David Gilmour

IPC分类号： A61K33/24

CPC分类号： A61K33/24

摘要： This disclosure relates to the treatment of subjects at risk for chronic kidney disease (CKD), having stage one to five CKD, having hyperphosphataemia, susceptible to or suffering from soft tissue calcification associated with CKD, or susceptible to or suffering from hyperparathyroidism, by orally administering a pharmaceutical composition containing a therapeutically effective amount of lanthanum hydroxycarbonate.

摘要翻译： 本公开涉及通过口服治疗具有慢性肾脏疾病（CKD）风险的患有慢性肾脏疾病（CKD）的患有慢性肾脏疾病（CKD）的患有高钙血症，具有与CKD相关的软组织钙化易感或患有甲状旁腺功能亢进的高磷酸血症 施用含有治疗有效量的羟基碳酸镧的药物组合物。

公开(公告)号：US20060121127A1

公开(公告)日：2006-06-08

申请号：US11272569

申请日：2005-11-09

申请人： Josephine Ferdinando ,  Peter Davies

发明人： Josephine Ferdinando ,  Peter Davies

IPC分类号： A61K33/24 ,  A61K9/20 ,  A61K31/7012 ,  A61K31/70

CPC分类号： A61K33/24 ,  A61J3/10 ,  A61K9/0056 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2059 ,  Y10S514/96

摘要： Stabilized lanthanum carbonate compositions containing a monosaccharide or disaccharide stabilizing agent are disclosed. Subjects having hyperphosphatemia can be treated by administering a pharmaceutical composition containing a therapeutically effective amount of the stabilized lanthanum carbonate formulation.

摘要翻译： 公开了含有单糖或二糖稳定剂的稳定的碳酸镧组合物。 可以通过施用含有治疗有效量的稳定的碳酸镧制剂的药物组合物来治疗具有高磷酸血症的受试者。

公开(公告)号：US20050079135A1

公开(公告)日：2005-04-14

申请号：US10926330

申请日：2004-08-26

申请人： Robert Haslam ,  Laura Trespidi ,  Josephine Ferdinando

发明人： Robert Haslam ,  Laura Trespidi ,  Josephine Ferdinando

IPC分类号： A61J3/10 ,  A61K9/00 ,  A61K9/20 ,  A61K33/24 ,  A61P13/12 ,  A61K33/00

CPC分类号： A61K9/0056 ,  A61J3/10 ,  A61K9/2018 ,  A61K33/24

摘要： This invention relates to a chewable lanthanum formulation comprising a pharmaceutically effective amount of a lanthanum compound; and at least one chewable pharmaceutically acceptable excipient. This invention also relates to a pharmaceutical formulation in a tablet or in a powder comprising a pharmaceutically effective amount of a lanthanum compound produced by a process which comprises the steps of: a) powder blending the lanthanum compound and at least one pharmaceutically acceptable excipient in a mixer to form a mixture; or b) powder blending the lanthanum compound and excipients, compressing the resulting combination into a slug material or roller compacting the resulting combination into a strand material, and milling the prepared material into a free flowing mixture; and c)compressing the resulting mixture into a tablet or filing up the resulting mixture in a appropriate container.

摘要翻译： 本发明涉及含有药物有效量的镧化合物的咀嚼镧制剂; 和至少一种可咀嚼的药学上可接受的赋形剂。 本发明还涉及片剂或粉末中的药物制剂，其包含药学有效量的通过包括以下步骤的方法制备的镧化合物：a）将镧化合物和至少一种药学上可接受的赋形剂在 混合器形成混合物; 或b）将镧化合物和赋形剂混合的粉末，将所得组合物压缩成块状材料或辊，将所得组合压实成股线材料，并将制备的材料研磨成自由流动的混合物; 和c）将所得混合物压制成片剂或将所得混合物填充在合适的容器中。