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公开(公告)号:US07208581B1
公开(公告)日:2007-04-24
申请号:US09706325
申请日:2000-11-03
申请人: Juan M. Zapata , John C. Reed
发明人: Juan M. Zapata , John C. Reed
CPC分类号: C07K16/18
摘要: In accordance with the present invention, there are provided novel TRAF-Protein-Binding-Domain polypeptides (TPBDs). The invention also provides nucleic acid molecules encoding TPBDs, vectors containing these nucleic acid molecules and host cells containing the vectors. The invention also provides antibodies that can specifically bind to invention TPBDs. Such TPBDs and/or anti-TPBD antibodies are useful for discovery of drugs that suppress autoimmunity, inflammation, allergy, allograph rejection, sepsis, and other diseases.
摘要翻译: 根据本发明,提供了新型TRAF-蛋白结合域多肽(TPBD)。 本发明还提供编码TPBD的核酸分子,含有这些核酸分子的载体和含有载体的宿主细胞。 本发明还提供可以特异性结合本发明的TPBD的抗体。 这样的TPBD和/或抗TPBD抗体可用于发现抑制自身免疫,炎症,过敏,同种异体排斥,败血症和其它疾病的药物。
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公开(公告)号:US07666607B1
公开(公告)日:2010-02-23
申请号:US11788741
申请日:2007-04-20
申请人: Juan M. Zapata , John C. Reed
发明人: Juan M. Zapata , John C. Reed
CPC分类号: C07K16/18
摘要: In accordance with the present invention, there are provided novel TRAF-Protein-Binding-Domain polypeptides (TPBDs). The invention also provides nucleic acid molecules encoding TPBDs, vectors containing these nucleic acid molecules and host cells containing the vectors. The invention also provides antibodies that can specifically bind to invention TPBDs. Such TPBDs and/or anti-TPBD antibodies are useful for discovery of drugs that suppress autoimmunity, inflammation, allergy, allograph rejection, sepsis, and other diseases.
摘要翻译: 根据本发明,提供了新型TRAF-蛋白结合域多肽(TPBD)。 本发明还提供编码TPBD的核酸分子,含有这些核酸分子的载体和含有载体的宿主细胞。 本发明还提供可以特异性结合本发明的TPBD的抗体。 这样的TPBD和/或抗TPBD抗体可用于发现抑制自身免疫,炎症,过敏,同种异体排斥,败血症和其它疾病的药物。
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公开(公告)号:US20100324267A1
公开(公告)日:2010-12-23
申请号:US12642723
申请日:2009-12-18
申请人: Juan M. Zapata , John C. Reed
发明人: Juan M. Zapata , John C. Reed
CPC分类号: C07K16/18
摘要: In accordance with the present invention, there are provided novel TRAF-Protein-Binding-Domain polypeptides (TPBDs). The invention also provides nucleic acid molecules encoding TPBDs, vectors containing these nucleic acid molecules and host cells containing the vectors. The invention also provides antibodies that can specifically bind to invention TPBDs. Such TPBDs and/or anti-TPBD antibodies are useful for discovery of drugs that suppress autoimmunity, inflammation, allergy, allograph rejection, sepsis, and other diseases.
摘要翻译: 根据本发明,提供了新型TRAF-蛋白结合域多肽(TPBD)。 本发明还提供编码TPBD的核酸分子,含有这些核酸分子的载体和含有载体的宿主细胞。 本发明还提供可以特异性结合本发明的TPBD的抗体。 这样的TPBD和/或抗TPBD抗体可用于发现抑制自身免疫,炎症,过敏,同种异体排斥,败血症和其它疾病的药物。
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