公开(公告)号：US20070275012A1

公开(公告)日：2007-11-29

申请号：US10576158

申请日：2004-10-20

申请人： Julio Aguilar Rubido ,  Enrique Iglesias Perez ,  Yadira Lobaina Mato ,  Daymir Garcia Gonzalez ,  Verena Muzio Gonzalez ,  Gerardo Guillen Nieto ,  Nelson Acosta Rivero ,  Raimundo Ubieta Gomez ,  Julio Alvarez Obregon ,  Santiago Duenas Carrera ,  Carlos Duarte Cano ,  Peter Vanlandshoot ,  Luis Herrera Martinez

发明人： Julio Aguilar Rubido ,  Enrique Iglesias Perez ,  Yadira Lobaina Mato ,  Daymir Garcia Gonzalez ,  Verena Muzio Gonzalez ,  Gerardo Guillen Nieto ,  Nelson Acosta Rivero ,  Raimundo Ubieta Gomez ,  Julio Alvarez Obregon ,  Santiago Duenas Carrera ,  Carlos Duarte Cano ,  Peter Vanlandshoot ,  Luis Herrera Martinez

IPC分类号： A61K39/295 ,  A61P31/12

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/21 ,  A61K39/29 ,  A61K39/292 ,  A61K2039/54 ,  A61K2039/543 ,  A61K2039/545 ,  A61K2039/55516 ,  A61K2039/70 ,  C12N2730/10122 ,  C12N2730/10134 ,  C12N2740/16034 ,  C12N2770/24234

摘要： The present invention is related with the field of therapeutic vaccines against pathogens causing chronic diseases. It comprises the use in therapy of formulations containing the Hepatitis B surface antigen (HBsAg) as the main compound. The HBsAg is produced as a recombinant product in Picchia pastoris. The formulations of the present invention also comprise the combination of the Hepatitis B surface antigen and other coadministered antigens. The resulting formulations are able to generate potent lymphoprolipherative and cytotoxic responses apart from a remarkable response of specific antibodies, which make them very effective in the treatment of such diseases.

摘要翻译： 本发明涉及针对引起慢性病的病原体的治疗性疫苗领域。 它包括用于治疗含有乙型肝炎表面抗原（HBsAg）作为主要化合物的制剂。 HBsAg作为重组产品在Picchia pastoris中生产。 本发明的制剂还包括乙型肝炎表面抗原和其他共同施用的抗原的组合。 除了特异性抗体的显着反应之外，所得制剂能够产生有效的淋巴细胞扩增和细胞毒性应答，这使得它们在治疗这些疾病方面非常有效。