公开(公告)号：US20240156945A1

公开(公告)日：2024-05-16

申请号：US18282423

申请日：2022-03-17

申请人： Joseph COTROPIA ,  Gaurav CHANDRA

发明人： Joseph COTROPIA ,  Gaurav CHANDRA

IPC分类号： A61K39/21 ,  A61K39/00 ,  C07K14/005 ,  C07K16/10 ,  C12Q1/70 ,  G01N33/569

CPC分类号： A61K39/21 ,  C07K14/005 ,  C07K16/1063 ,  C12Q1/703 ,  G01N33/56988 ,  A61K2039/505 ,  C12N2740/16034 ,  G01N2333/162

摘要： Provided are highly conserved antigens and epitopes of HIV that can be used in vaccines and to produce bindings proteins (e.g., antibodies) for detecting, treating, preventing, or reducing the risk of HIV infection and the development of AIDS.

公开(公告)号：US11969427B2

公开(公告)日：2024-04-30

申请号：US17329893

申请日：2021-05-25

申请人： EMORY UNIVERSITY ,  CHILDREN'S HEALTHCARE OF ATLANTA, INC.

发明人： Raymond F Schinazi ,  Christina Gavegnano

IPC分类号： A61K38/00 ,  A61K31/519 ,  A61K38/08 ,  A61K38/10 ,  A61K38/17 ,  A61K45/06 ,  A61P31/14 ,  A61P31/18 ,  C07K16/28

CPC分类号： A61K31/519 ,  A61K38/08 ,  A61K38/10 ,  A61K38/17 ,  A61K38/1709 ,  A61K45/06 ,  A61P31/14 ,  A61P31/18 ,  C12N2740/16034 ,  Y02A50/30 ,  A61K31/519 ,  A61K2300/00 ,  A61K38/08 ,  A61K2300/00 ,  A61K38/10 ,  A61K2300/00 ,  A61K38/1709 ,  A61K2300/00

摘要： Compounds, compositions, and methods of treatment and prevention of HIV, including HIV-1 and HIV-2, Dengue, and Chikungunya infection are disclosed. The compounds are TREM-1 inhibitors. Combinations of these TREM-1 inhibitors and additional antiretroviral compounds, such as NRTI, NNRTI, integrase inhibitors, entry inhibitors, protease inhibitors, JAK inhibitors, macrophage depleting agents, and the like, are also disclosed. In one embodiment, the combinations include a combination of adenine, cytosine, thymidine, and guanine nucleoside antiviral agents, optionally in further combination with at least one additional antiviral agent that works via a different mechanism than a nucleoside analog. This combination has the potential to eliminate the presence of HIV, Dengue, or Chikungunya virus in an infected patient.

公开(公告)号：US20240131148A1

公开(公告)日：2024-04-25

申请号：US18257808

申请日：2021-12-17

申请人： THE SCRIPPS RESEARCH INSTITUTE

发明人： William R. SCHIEF ,  Torben SCHIFFNER ,  Jon M. STEICHEN ,  Xiaozhen HU

IPC分类号： A61K39/215 ,  A61K39/00 ,  C07K14/005 ,  C12N7/00 ,  C12N9/88

CPC分类号： A61K39/215 ,  C07K14/005 ,  C12N7/00 ,  C12N9/88 ,  A61K2039/53 ,  C12N2740/16034 ,  C12N2760/20034 ,  C12N2770/20034 ,  C12Y402/0101

摘要： Provided herein are glycan engineered SARS-CoV-2 RBD polypeptides, fusion polypeptides comprising thereof, and immunogenic compositions comprising thereof. Also provided are methods of administering the RBD polypeptide, fusion polypeptide or immunogenic composition to a subject to elicit an immune response. Also provided are polynucleotides encoding the fusion polypeptide, and methods of administering a composition comprising the polynucleotide to a subject to elicit an immune response. In some embodiments, the polynucleotide is an RNA comprising modified ribonucleotides.

公开(公告)号：US11814413B2

公开(公告)日：2023-11-14

申请号：US16615768

申请日：2018-05-25

申请人： Duke University

发明人： Barton F. Haynes ,  David Montefiori ,  Kevin J. Wiehe ,  Kevin O. Saunders ,  Celia C. Labranche

IPC分类号： A61K39/21 ,  A61K39/39 ,  A61K45/06 ,  A61K39/00 ,  C07K14/005 ,  A61P31/18 ,  C12N7/00

CPC分类号： C07K14/005 ,  A61K39/21 ,  A61P31/18 ,  C12N7/00 ,  A61K2039/53 ,  A61K2039/55572 ,  C12N2740/16034 ,  C12N2740/16122

摘要： The invention is directed to immunogens and methods for inducing immune responses, comprising methods for germline B cell stimulation and maturation by reverse engineering of HIV-1 envelopes.

公开(公告)号：US20230312658A1

公开(公告)日：2023-10-05

申请号：US18067525

申请日：2022-12-16

申请人： Centivax, Inc.

发明人： Jacob E. Glanville

IPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/21 ,  A61K38/46 ,  G16B30/10 ,  A61K39/00 ,  G16C20/60 ,  C12N7/00 ,  G16B35/00 ,  G16B20/30 ,  G16B30/00 ,  G16B35/10 ,  G16B20/00

CPC分类号： C07K14/005 ,  A61K38/46 ,  A61K39/0011 ,  A61K39/12 ,  A61K39/21 ,  C12N7/00 ,  G16B20/30 ,  G16B30/00 ,  G16B30/10 ,  G16B35/00 ,  G16B35/10 ,  G16C20/60 ,  A61K2039/515 ,  A61K2039/5154 ,  A61K2039/53 ,  A61K2039/575 ,  A61K2039/70 ,  C12N2740/16034 ,  C12N2740/16071 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12Y306/05002 ,  G16B20/00

摘要： The present disclosure provides compositions and methods for the generation of an antibody or immunogenic composition, such as a vaccine, through epitope focusing by variable effective antigen surface concentration. Generally, the composition and methods of the disclosure comprise three steps: a “design process” comprising one or more in silico bioinformatics steps to select and generate a library of potential antigens for use in the immunogenic composition; a “formulation process”, comprising in vitro testing of potential antigens, using various biochemical assays, and further combining two or more antigens to generate one or more immunogenic compositions; and an “administering” step, whereby the immunogenic composition is administered to a host animal, immune cell, subject or patient. Further steps may also be included, such as the isolation and production of antibodies raised by host immune response to the immunogenic composition.

公开(公告)号：US11672853B2

公开(公告)日：2023-06-13

申请号：US16431099

申请日：2019-06-04

申请人： Academia Sinica

发明人： Chi-Huey Wong ,  Che Ma ,  Cheng-Chi Wang ,  Juine-Ruey Chen

IPC分类号： A61K39/145 ,  C12N7/00 ,  A61K39/12 ,  C07K16/10 ,  A61K39/00

CPC分类号： A61K39/145 ,  A61K39/12 ,  C07K16/1018 ,  C12N7/00 ,  A61K2039/55505 ,  C07K2317/76 ,  C12N2740/11034 ,  C12N2740/16034 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16171 ,  C12N2770/24134 ,  Y02A50/30

摘要： Immunogenic compositions comprising partially glycosylated viral glycoproteins for use as vaccines against viruses are provided. Vaccines formulated using mono-, di-, or tri-glycosylated viral surface glycoproteins and polypeptides provide potent and broad protection against viruses, even across strains. Pharmaceutical compositions comprising monoglycosylated hemagglutinin polypeptides and vaccines generated therefrom and methods of their use for prophylaxis or treatment of viral infections are disclosed. Methods and compositions are disclosed for influenza virus HA, NA and M2, RSV proteins F, G and SH, Dengue virus glycoproteins M or E, hepatitis C virus glycoprotein E1 or E2 and HIV glycoproteins gp120 and gp41.

公开(公告)号：US20190201342A1

公开(公告)日：2019-07-04

申请号：US16353303

申请日：2019-03-14

申请人： Her Majesty the Queen in Right of Canada as Represented by the Minister of Health

发明人： Ma Luo

IPC分类号： A61K9/14 ,  A61K39/21 ,  C07K14/74 ,  C07K14/005 ,  A61K39/12 ,  C07K14/16 ,  A61P31/18 ,  A61P37/04

CPC分类号： A61K9/14 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/55555 ,  A61K2039/57 ,  A61P31/18 ,  A61P37/04 ,  C07K14/005 ,  C07K14/161 ,  C07K14/163 ,  C07K14/70539 ,  C12N2740/15034 ,  C12N2740/16022 ,  C12N2740/16034 ,  C12N2740/16222 ,  C12N2740/16322 ,  C12N2760/18043

摘要： Instead of generating immune responses to several HIV proteins and risk over activating more CD4+ T cells (easy targets for HIV-1 infection) as current candidate vaccines try to do, a lower magnitude, narrowly focused, well maintained virus specific CD8+ T cell response to multiple subtypes should destroy and eliminate a few founder viruses without inducing inflammatory responses that may activate more CD4+ T cells and provide more targets for HIV-1 virus infection. Specifically, described herein is a method that focuses the immune response to the 12 protease cleavage sites.

公开(公告)号：US20180326044A1

公开(公告)日：2018-11-15

申请号：US15768250

申请日：2016-10-13

申请人： Daniel C. CARTER

发明人： Daniel C. CARTER

IPC分类号： A61K39/15 ,  C07K14/44 ,  C07K14/005 ,  G01N33/569

CPC分类号： A61K39/15 ,  A61K39/12 ,  A61K2039/6031 ,  A61K2039/64 ,  C07K14/005 ,  C07K14/44 ,  C07K2319/00 ,  C12N2720/12034 ,  C12N2740/16034 ,  C12N2760/16134 ,  C12N2770/20022 ,  C12N2770/20034 ,  C12N2770/20071 ,  G01N33/56983 ,  Y02A50/383 ,  Y02A50/386 ,  Y02A50/388 ,  Y02A50/39 ,  Y02A50/392 ,  Y02A50/396 ,  Y02A50/41 ,  Y02A50/412 ,  Y02A50/414 ,  Y02A50/466

摘要： A fusion protein is provided which is based on a self-assembling gene-regulatory NSP10 protein and a protein or peptide capable of being fused to NSP10 without interfering with the assembly or aggregation of the resulting fusion protein. The disclosure also relates to any nanoparticle formed thereby whether complete or not, and methods for the use of the NSP10 fusion protein are also disclosed, including use as vaccines for any indication in humans or animals, therapeutic methods involving the use of the fusion proteins such as using the protein to targeted an antibody or receptor, such as for treating or diagnosing cancer, bio-sensors using the fusion protein, or the use of the fusion proteins in cell sorting or any imaging application.

公开(公告)号：US10076567B2

公开(公告)日：2018-09-18

申请号：US15024600

申请日：2014-09-29

申请人： Duke University ,  Los Alamos National Security, LLC

发明人： Barton F. Haynes ,  Bette T. Korber ,  S. Munir Alam

IPC分类号： A61K39/21 ,  A61K38/16 ,  A61K38/21 ,  A61K9/127 ,  A61K9/00 ,  A61K39/12 ,  A61K47/48 ,  C07K14/005 ,  A61K39/39 ,  C12N7/00 ,  A61K39/00

CPC分类号： A61K39/21 ,  A61K9/0019 ,  A61K9/127 ,  A61K38/162 ,  A61K38/212 ,  A61K39/12 ,  A61K39/39 ,  A61K47/6911 ,  A61K2039/545 ,  A61K2039/55555 ,  A61K2039/55572 ,  A61K2039/575 ,  C07K14/005 ,  C12N7/00 ,  C12N2740/16022 ,  C12N2740/16034 ,  C12N2740/16122 ,  C12N2740/16134 ,  A61K2300/00

摘要： The present invention relates to peptides and compositions suitable for use in inducing anti-HIV-1 antibodies. The compositions comprise HIV-1 gp41 membrane proximal external region (MPER) peptide-liposome conjugates for induction of broadly reactive anti-HIV-1 antibodies. The invention also relates to methods of inducing neutralizing anti-HIV-1 antibodies using such compositions.

公开(公告)号：US20180228885A1

公开(公告)日：2018-08-16

申请号：US15751640

申请日：2016-08-10

申请人： ORBIS HEALTH SOLUTIONS LLC

发明人： Thomas E. Wagner

IPC分类号： A61K39/095 ,  A61K39/12

CPC分类号： A61K39/095 ,  A61K39/12 ,  A61K2039/523 ,  A61K2039/55505 ,  A61K2039/572 ,  A61K2039/6006 ,  C12N2740/16034 ,  C12N2740/16234 ,  C12N2740/16334 ,  C12N2760/16134

摘要： The present invention generally relates to compositions and methods for delivering a vaccine. The compositions and methods disclosed herein are particularly useful in making bacterial and viral vaccines.