公开(公告)号：US06355414B1

公开(公告)日：2002-03-12

申请号：US09380790

申请日：2000-01-06

申请人： Julio Cesar Aguilar Rubido ,  Verena Lucila Muzio Gonzalez ,  Maria de Jesus Leal Angulo ,  Gerardo Enrique Guillen Nieto ,  Eduardo Penton Arias ,  Gloria Veliz Rios ,  Dagmara Pichardo Diaz ,  Antonieta Herrera Buch ,  Enrique Iglesias Perez ,  Luis Javier Cruz Ricondo ,  Tania Carmenate Portilla ,  Cirse Mesa Pardillo ,  Maydel Hechavarria Gay ,  Maylin Diaz Martinez ,  Juan Joel Madrazo Piñol

发明人： Julio Cesar Aguilar Rubido ,  Verena Lucila Muzio Gonzalez ,  Maria de Jesus Leal Angulo ,  Gerardo Enrique Guillen Nieto ,  Eduardo Penton Arias ,  Gloria Veliz Rios ,  Dagmara Pichardo Diaz ,  Antonieta Herrera Buch ,  Enrique Iglesias Perez ,  Luis Javier Cruz Ricondo ,  Tania Carmenate Portilla ,  Cirse Mesa Pardillo ,  Maydel Hechavarria Gay ,  Maylin Diaz Martinez ,  Juan Joel Madrazo Piñol

IPC分类号： C12Q170

CPC分类号： A61K39/095 ,  A61K39/12 ,  A61K39/292 ,  A61K2039/54 ,  A61K2039/543 ,  A61K2039/55544 ,  A61K2039/55583 ,  A61K2039/55588 ,  C12N2730/10134 ,  Y10S514/885 ,  Y10S977/906

摘要： The present invention is related to the field of medicine, particularly to the use of new adjuvant formulations with vaccine antigens. The technical objective pursued with this invention is, precisely, the development of formulations that are able to increase and/or modulate the immune response of the organism to vaccine antigens in the serum and the mucous lining. With this aim, a formulation was developed that contained as the main components the surface antigen of the hepatitis B virus and the acemannan in adequate proportions. As an extension of this result, formulations were developed in which a) HBsAg was used as the homologous or heterologous antigen carrier b) delivery systems of particulated antigens and c) soluble antigens, combined with the acemannan in specific proportions. The formulations of this invention are applicable in the pharmaceutical industry as vaccine formulations for human and veterinary use.

摘要翻译： 本发明涉及药物领域，特别是涉及使用具有疫苗抗原的新辅助制剂。 本发明追求的技术目标正是开发能够增加和/或调节生物体对血清和粘液衬里中的疫苗抗原的免疫应答的制剂。 为此，开发了一种配方，其中包含乙肝病毒的表面抗原和乙酰甘露聚糖的主要成分。 作为该结果的延伸，开发了其中a）将HBsAg用作同源或异源抗原载体b）颗粒抗原的递送系统和c）可溶性抗原与特定比例的acemannan结合的制剂。 本发明的制剂可用于制药工业，作为用于人类和兽医用途的疫苗制剂。