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公开(公告)号:US20100093620A1
公开(公告)日:2010-04-15
申请号:US12433037
申请日:2009-04-30
CPC分类号: C07K14/43504 , A61K38/00
摘要: The invention relates to relatively short peptides (termed Conopeptide-Y family peptides or CPY family peptides or CPY peptides herein), about 30 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which are rich in the amino acid tyrosine.
摘要翻译: 本发明涉及相对较短的肽(本文称为Conopeptide-Y家族肽或CPY家族肽或CPY肽),其长度约为30个残基,其在锥形蜗牛的毒液中以天然可天然获得或类似于天然可获得的 肽,富含氨基酸酪氨酸。
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公开(公告)号:US20120220539A1
公开(公告)日:2012-08-30
申请号:US13289494
申请日:2011-11-04
CPC分类号: C07K14/43504 , A61K38/00
摘要: The present invention relates conotoxin peptides that are analogs of the α-contoxin peptide RgIA. These conotoxin peptides block the α9α10 subtype of the nicotinic acetylcholine receptor (nAChR) and can be used for treating pain, such as neuropathic pain and inflammatory pain, inflammatory disorders, such as rheumatic diseases, and in the treatment of breast cancer.
摘要翻译: 本发明涉及作为α-轮廓蛋白肽RgIA的类似物的荚果毒素肽。 这些芋螺毒素肽阻断烟碱乙酰胆碱受体(nAChR)的α9α10亚型,可用于治疗疼痛,如神经性疼痛和炎性疼痛,炎性疾病如风湿性疾病,以及乳腺癌的治疗。
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公开(公告)号:US20120149869A1
公开(公告)日:2012-06-14
申请号:US13367839
申请日:2012-02-07
申请人: Maren WATKINS , Baldomero M. OLIVERA , David R. HILLYARD , J. Michael MCINTOSH , Robert M. JONES
发明人: Maren WATKINS , Baldomero M. OLIVERA , David R. HILLYARD , J. Michael MCINTOSH , Robert M. JONES
IPC分类号: C07K9/00 , C07K14/435 , C07K7/08
CPC分类号: C07K14/43504 , A61K38/00 , C07K7/08 , C07K9/00 , Y10S530/855 , Y10S530/857
摘要: The invention relates to relatively short peptides (termed α-conotoxins herein), about 10-30 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.
摘要翻译: 本发明涉及相对较短的肽(本文称为α-芋螺毒素),长度约10-30个残基,其在锥形蜗牛的毒液中天然可以微量天然存在或类似于天然可得的肽,并且优选包括两个 二硫键。
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公开(公告)号:US20110166322A1
公开(公告)日:2011-07-07
申请号:US13042832
申请日:2011-03-08
申请人: Maren WATKINS , Baldomero M. OLIVERA , David R. HILLYARD , J. Michael McINTOSH , Robert M. JONES
发明人: Maren WATKINS , Baldomero M. OLIVERA , David R. HILLYARD , J. Michael McINTOSH , Robert M. JONES
IPC分类号: C07K7/08 , C07K14/435
CPC分类号: C07K14/43504 , A61K38/00 , C07K7/08 , C07K9/00 , Y10S530/855 , Y10S530/857
摘要: The invention relates to relatively short peptides (termed α-conotoxins herein), about 10-30 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.
摘要翻译: 本发明涉及相对较短的肽(本文称为α-芋螺毒素),长度约10-30个残基,其在锥形蜗牛的毒液中天然可以微量天然存在或类似于天然可得的肽,并且优选包括两个 二硫键。
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公开(公告)号:US20100145011A1
公开(公告)日:2010-06-10
申请号:US12706911
申请日:2010-02-17
申请人: Maren WATKINS , Baldomero M. OLIVERA , David R. HILLYARD , J. Michael MCINTOSH , Robert M. JONES
发明人: Maren WATKINS , Baldomero M. OLIVERA , David R. HILLYARD , J. Michael MCINTOSH , Robert M. JONES
IPC分类号: C07K14/435
CPC分类号: C07K14/43504 , A61K38/00 , C07K7/08 , C07K9/00 , Y10S530/855 , Y10S530/857
摘要: The invention relates to relatively short peptides (termed α-conotoxins herein), about 10-30 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.
摘要翻译: 本发明涉及相对较短的肽(本文称为α-芋螺毒素),长度约10-30个残基,其在锥形蜗牛的毒液中天然可以微量天然存在或类似于天然可得的肽,并且优选包括两个 二硫键。
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