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公开(公告)号：US08487075B2
公开(公告)日：2013-07-16
申请号：US13367839
申请日：2012-02-07
申请人： Maren Watkins , Baldomero M. Olivera , David R. Hillyard , J. Michael McIntosh , Robert M. Jones
发明人： Maren Watkins , Baldomero M. Olivera , David R. Hillyard , J. Michael McIntosh , Robert M. Jones
CPC分类号： C07K14/43504 , A61K38/00 , C07K7/08 , C07K9/00 , Y10S530/855 , Y10S530/857
摘要： The invention relates to relatively short peptides (termed α-conotoxins herein), about 10-30 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.
摘要翻译： 本发明涉及相对短的肽（本文中称为α-芋螺毒素），长度约10-30个残基，其在锥形蜗牛的毒液中天然可以微量天然存在或类似于天然可得的肽，并且其优选包括两个 二硫键。
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2.发明授权Nucleic acid molecule comprising a nucleic acid sequence which codes for a haemocyanin 有权核酸分子，其包含编码血蓝蛋白的核酸序列公开(公告)号：US07282578B2
公开(公告)日：2007-10-16
申请号：US11511952
申请日：2006-08-29
IPC分类号： C07H21/00
CPC分类号： C07K14/43504 , A61K39/0003 , A61K2039/6081 , Y02A50/423 , Y10S530/855
摘要： A nucleic acid molecule or construct alone or with a promoter suitable for expression control is contemplated that codes for a KLH1 haemocyanin, a haemocyanin domain or a fragment thereof with the immunological properties of at least one domain of haemocyanin, and comprises at least one intron sequence, as well as haemocyanin fusion proteins. The construct can also comprise a nucleic acid sequence that codes for an antigen. Host cells are also contemplated that contain the nucleic acid molecule or construct and a recombinant expression product thereof. The invention further relates to a pharmaceutical composition that comprises the expression product and antibodies obtainable by immunization of an animal therewith, as well as the use of antibodies in screening methods for the identification of tumors.
摘要翻译： 预期单独或具有适用于表达控制的启动子的核酸分子或构建体编码具有至少一个血蓝蛋白结构域的免疫学特性的KLH1血蓝蛋白，血蓝蛋白结构域或其片段，并且包含至少一个内含子序列 ，以及血蓝蛋白融合蛋白。 构建体还可以包含编码抗原的核酸序列。 还考虑了含有核酸分子或构建体及其重组表达产物的宿主细胞。 本发明还涉及一种药物组合物，其包含表达产物和通过用其免疫动物可获得的抗体，以及在鉴定肿瘤的筛选方法中使用抗体。
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公开(公告)号：US20070154920A1
公开(公告)日：2007-07-05
申请号：US11611011
申请日：2006-12-14
申请人： Glenn Frank , Shirley Hunter , Lynda Wallenfels
发明人： Glenn Frank , Shirley Hunter , Lynda Wallenfels
CPC分类号： C07K14/4359 , A61K38/17 , C12Q1/6883 , C12Q2600/142 , C12Q2600/158 , Y10S530/855 , Y10S530/858 , Y10S530/868
摘要： The present invention is directed to a novel product and method for isolating ectoparasite saliva proteins, and a novel product and method for detecting and/or treating allergic dermatitis in an animal. The present invention includes a saliva protein collection apparatus capable of collecting ectoparasite saliva proteins substantially free of contaminating material. The present invention also relates to ectoparasite saliva proteins, nucleic acid molecules having sequences that encode such proteins, and antibodies raised against such proteins. The present invention also includes methods to obtain such proteins and to use such proteins to identify animals susceptible to or having allergic dermatitis. The present invention also includes therapeutic compositions comprising such proteins and their use to treat animals susceptible to or having allergic dermatitis.
摘要翻译： 本发明涉及一种用于分离外寄生唾液蛋白质的新产品和方法，以及用于在动物中检测和/或治疗过敏性皮炎的新产品和方法。 本发明包括能够收集基本上不含污染物质的外寄生唾液蛋白质的唾液蛋白质收集装置。 本发明还涉及外寄生物唾液蛋白质，具有编码这种蛋白质的序列的核酸分子和针对这种蛋白质产生的抗体。 本发明还包括获得这种蛋白质和使用这些蛋白质鉴定易感或具有过敏性皮炎的动物的方法。 本发明还包括包含这些蛋白质的治疗组合物及其用于治疗易感或具有过敏性皮炎的动物的用途。
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公开(公告)号：US07166693B2
公开(公告)日：2007-01-23
申请号：US10271344
申请日：2002-10-14
CPC分类号： C07K14/4359 , A61K38/17 , C12Q1/6883 , C12Q2600/142 , C12Q2600/158 , Y10S530/855 , Y10S530/858 , Y10S530/868
摘要： The present invention is directed to a novel product and method for isolating ectoparasite saliva proteins, and a novel product and method for detecting and/or treating allergic dermatitis in an animal. The present invention includes a saliva protein collection apparatus capable of collecting ectoparasite saliva proteins substantially free of contaminating material. The present invention also relates to ectoparasite saliva proteins, nucleic acid molecules having sequences that encode such proteins, and antibodies raised against such proteins. The present invention also includes methods to obtain such proteins and to use such proteins to identify animals susceptible to or having allergic dermatitis. The present invention also includes therapeutic compositions comprising such proteins and their use to treat animals susceptible to or having allergic dermatitis.
摘要翻译： 本发明涉及一种用于分离外寄生唾液蛋白质的新产品和方法，以及用于在动物中检测和/或治疗过敏性皮炎的新产品和方法。 本发明包括能够收集基本上不含污染物质的外寄生唾液蛋白质的唾液蛋白质收集装置。 本发明还涉及外寄生物唾液蛋白质，具有编码这种蛋白质的序列的核酸分子和针对这种蛋白质产生的抗体。 本发明还包括获得这种蛋白质和使用这些蛋白质鉴定易感或具有过敏性皮炎的动物的方法。 本发明还包括包含这些蛋白质的治疗组合物及其用于治疗易感或具有过敏性皮炎的动物的用途。
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5.发明授权Nucleic acid molecule comprising a nucleic acid sequence which codes for a haemocyanin, and comprising at least one intron sequence 有权核酸分子，其包含编码血蓝蛋白的核酸序列，并且包含至少一个内含子序列公开(公告)号：US07125557B1
公开(公告)日：2006-10-24
申请号：US10049988
申请日：2000-08-21
CPC分类号： C12Y110/03001 , A61K38/00 , A61K48/00 , A61K2039/53 , C07K14/43504 , C07K2319/00 , C07K2319/02 , C07K2319/21 , C12N9/0059 , G01N33/57496 , Y02A50/423 , Y10S530/855
摘要： A nucleic acid molecule or construct alone or with a promoter suitable for expression control is contemplated that codes for a haemocyanin, a haemocyanin domain or a fragment thereof with the immunological properties of at least one domain of haemocyanin, and comprises at least one intron sequence, as well as haemocyanin fusion proteins. The construct furthermore can comprise a nucleic acid sequence that codes for an antigen. Host cells are also contemplated that contain the nucleic acid molecule or construct and a recombinant expression product thereof. The invention furthermore relates to a pharmaceutical composition that comprises the expression product and antibodies obtainable by immunization of an animal therewith, as well as the use the antibodies in screening methods for the identification of tumors.
摘要翻译： 预期单独或具有适用于表达控制的启动子的核酸分子或构建体编码具有至少一个血蓝蛋白结构域的免疫学特性的血蓝蛋白，血蓝蛋白结构域或其片段，并且包含至少一个内含子序列， 以及血蓝蛋白融合蛋白。 该构建体还可以包含编码抗原的核酸序列。 还考虑了含有核酸分子或构建体及其重组表达产物的宿主细胞。 本发明还涉及一种药物组合物，其包含表达产物和通过用其免疫动物可获得的抗体，以及在用于鉴定肿瘤的筛选方法中使用该抗体。
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6.发明授权Nucleic acid molecule comprising a nucleic acid sequence coding for a haemocyanin 有权包含编码血蓝蛋白的核酸序列的核酸分子公开(公告)号：US07125556B1
公开(公告)日：2006-10-24
申请号：US09936852
申请日：2000-03-17
CPC分类号： C07K14/43504 , A61K39/0003 , A61K2039/6081 , Y02A50/423 , Y10S530/855
摘要： A nucleic acid molecule or construct alone or with a promoter suitable for expression control is contemplated that codes for a haemocyanin, a haemocyanin domain or a fragment thereof with the immunological properties of at least one domain of haemocyanin, and comprises at least one intron sequence, as well as haemocyanin fusion proteins. The construct furthermore can comprise a nucleic acid sequence that codes for an antigen. Host cells are also contemplated that contain the nucleic acid molecule or construct and a recombinant expression product thereof. The invention furthermore relates to a pharmaceutical composition that comprises the expression product and antibodies obtainable by immunization of an animal therewith, as well as the use the antibodies in screening methods for the identification of tumors.
摘要翻译： 预期单独或具有适用于表达控制的启动子的核酸分子或构建体编码具有至少一个血蓝蛋白结构域的免疫学特性的血蓝蛋白，血蓝蛋白结构域或其片段，并且包含至少一个内含子序列， 以及血蓝蛋白融合蛋白。 该构建体还可以包含编码抗原的核酸序列。 还考虑了含有核酸分子或构建体及其重组表达产物的宿主细胞。 本发明还涉及一种药物组合物，其包含表达产物和通过用其免疫动物可获得的抗体，以及在用于鉴定肿瘤的筛选方法中使用该抗体。
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公开(公告)号：US20050271683A1
公开(公告)日：2005-12-08
申请号：US10527771
申请日：2003-09-11
IPC分类号： A61K39/00 , C07K14/435 , C07K16/18 , C12N15/12
CPC分类号： C07K14/4354 , A61K39/00 , C07K16/18 , Y02A50/489 , Y10S530/855
摘要： The present invention relates to nucleic acid sequences encoding Ostertagia ostertagi proteins and to parts of such nucleic acid sequences that encode an immunogenic fragment of such proteins, and to DNA fragments, recombinant DNA molecules, live recombinant carriers and host cells comprising such nucleic acid sequences or such parts thereof. The invention also relate to Ostertagia ostertagi proteins and immunogenic parts thereof encoded by such sequences. Furthermore, the present invention relates to vaccines comprising such nucleic acid sequences and parts thereof, DNA fragments, recombinant DNA molecules, live recombinant carriers and host cells comprising such nucleic acid sequences or such parts thereof, proteins or immunogenic parts thereof and antibodies against such proteins or immunogenic thereof. Also, the inventions relates to the use of said proteins in vaccines and for the manufacture of vaccines. Moreover, the invention relates to the use of aid nucleic acid sequences, proteins or antibodies for diagnostic or vaccination purposes. Finally the invention relates to diagnostic kits comprising such nucleic acids, proteins or antibodies against such proteins.
摘要翻译： 本发明涉及编码Ostertagia ostertagi蛋白质的核酸序列和编码这种蛋白质的免疫原性片段的这种核酸序列的部分，以及DNA片段，重组DNA分子，活重组载体和包含此类核酸序列的宿主细胞， 其部分。 本发明还涉及由这些序列编码的Ostertagia ostertagi蛋白及其免疫原性部分。 此外，本发明涉及包含此类核酸序列及其部分的DNA疫苗，DNA片段，重组DNA分子，活重组载体和包含此类核酸序列或其部分的宿主细胞，蛋白质或其免疫原性部分和针对此类蛋白质的抗体 或其免疫原性。 此外，本发明涉及所述蛋白质在疫苗中的用途以及制造疫苗。 此外，本发明涉及用于诊断或疫苗接种目的的辅助核酸序列，蛋白质或抗体的用途。 最后，本发明涉及包含这种蛋白质的核酸，蛋白质或抗体的诊断试剂盒。
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公开(公告)号：US20050032705A1
公开(公告)日：2005-02-10
申请号：US10895372
申请日：2004-07-21
申请人： Maren Watkins , Baldomero Olivera , David Hillyard , J. McIntosh , Robert Jones
发明人： Maren Watkins , Baldomero Olivera , David Hillyard , J. McIntosh , Robert Jones
IPC分类号： A61K38/00 , C07K14/435 , A61K38/10 , C07K7/08
CPC分类号： C07K14/43504 , A61K38/00 , C07K7/08 , C07K9/00 , Y10S530/855 , Y10S530/857
摘要： The invention relates to relatively short peptides (termed α-conotoxins herein), about 10-30 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.
摘要翻译： 本发明涉及相对短的肽（本文中称为α-芋螺毒素），长度约10-30个残基，其在锥形蜗牛的毒液中天然可以微量天然存在或类似于天然可得的肽，并且其优选包括两个 二硫键。
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公开(公告)号：US06319669B1
公开(公告)日：2001-11-20
申请号：US08727452
申请日：1997-03-20
申请人： Roger Y. Tsien , Roger Heim
发明人： Roger Y. Tsien , Roger Heim
IPC分类号： C12Q168
CPC分类号： C07K14/43595 , C12N15/65 , G01N33/533 , G01N2333/43595 , Y10S530/855
摘要： Modifications in the sequence of Aequorea wild-type GFP provide products having markedly different excitation and emission spectra from corresponding products from wild-type GFP. In one class of modifications, the product derived from the modified GFP exhibits an alteration in the ratio of two main excitation peaks observed with the product derived from wild-type GFP. In another class, the product derived from the modified GFP fluoresces at a shorter wavelength than the corresponding product from wild-type GFP. In yet another class of modifications, the product derived from the modified GFP exhibits only a single excitation peak and enhanced emission relative to the product derived from wild-type GFP.
摘要翻译： Aequorea野生型GFP序列的修饰提供了来自野生型GFP相应产物的产生明显不同的激发和发射光谱的产物。 在一类修饰中，衍生自经修饰的GFP的产物表现出与用野生型GFP产生的产物观察到的两个主要激发峰的比例的变化。 在另一类中，衍生自经修饰的GFP的产物在比来自野生型GFP的相应产物更短的波长处发荧光。 在另一类修饰中，衍生自经修饰的GFP的产物相对于衍生自野生型GFP的产物仅显示单个激发峰和增强的发射。
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公开(公告)号：US5625048A
公开(公告)日：1997-04-29
申请号：US337915
申请日：1994-11-10
申请人： Roger Y. Tsien , Roger Heim
发明人： Roger Y. Tsien , Roger Heim
IPC分类号： C12N15/09 , C07K14/435 , C12N5/10 , C12N15/12 , C12N15/65 , C12P21/04 , C12Q1/25 , C12Q1/68 , G01N33/533 , C07H21/04
CPC分类号： C07K14/43595 , C12N15/65 , G01N33/533 , G01N2333/43595 , Y10S530/855
摘要： Modifications in the sequence of Aequorea wild-type GFP provide products having markedly different excitation and emission spectra from corresponding products from wild-type GFP. In one class of modifications, the product derived from the modified GFP exhibits an alteration in the ratio of two main excitation peaks observed with the product derived from wild-type GFP. In another class, the product derived from the modified GFP fluoresces at a shorter wavelength than the corresponding product from wild-type GFP. In yet another class of modifications, the product derived from the modified GFP exhibits only a single excitation peak and enhanced emission relative to the product derived from wild-type GFP.
摘要翻译： Aequorea野生型GFP序列的修饰提供了来自野生型GFP相应产物的产生明显不同的激发和发射光谱的产物。 在一类修饰中，衍生自经修饰的GFP的产物表现出与用野生型GFP产生的产物观察到的两个主要激发峰的比例的变化。 在另一类中，衍生自经修饰的GFP的产物在比来自野生型GFP的相应产物更短的波长处发荧光。 在另一类修饰中，衍生自经修饰的GFP的产物相对于衍生自野生型GFP的产物仅显示单个激发峰和增强的发射。
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