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1.
公开(公告)号:US5948637A
公开(公告)日:1999-09-07
申请号:US770301
申请日:1996-12-20
申请人: Jun Ikeda , Sumiko Kaneda , Hideki Yanagi , Masayasu Matsumoto , Takashi Yura
发明人: Jun Ikeda , Sumiko Kaneda , Hideki Yanagi , Masayasu Matsumoto , Takashi Yura
CPC分类号: C07K14/47 , C07K14/435 , A61K38/00
摘要: A polypeptide obtainable by inducement under hypoxic conditions having a sequence comprising: (a) the amino acid sequence of SEQ ID NO:1 or 3 or a fragment thereof; (b) an amino acid sequence encoded by the nucleotide sequence of SEQ ID NO: 2 or 4 or a fragment thereof; or (c) an amino acid sequence resulting from deletion, addition, insertion or substitution of one or more amino acids in the amino acid sequence of SEQ ID NO:1 or 3; a polynucleotide encoding the above polypeptide or the fragment thereof useful for producing the above polypeptide by a biotechnological technique; and an antibody or fragment thereof specifically binding the above polypeptide.
摘要翻译: 通过在缺氧条件下诱导获得的多肽,其具有包含以下序列的序列:(a)SEQ ID NO:1或3的氨基酸序列或其片段; (b)由SEQ ID NO:2或4的核苷酸序列或其片段编码的氨基酸序列; 或(c)由SEQ ID NO:1或3的氨基酸序列中的一个或多个氨基酸的缺失,添加,插入或取代产生的氨基酸序列; 编码上述多肽或其片段的多核苷酸可用于通过生物技术生产上述多肽; 以及特异性结合上述多肽的抗体或其片段。
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公开(公告)号:US6034232A
公开(公告)日:2000-03-07
申请号:US175581
申请日:1998-10-20
申请人: Jun Ikeda , Sumiko Kaneda , Hideki Yanagi , Masayasu Matsumoto , Takashi Yura
发明人: Jun Ikeda , Sumiko Kaneda , Hideki Yanagi , Masayasu Matsumoto , Takashi Yura
CPC分类号: C07K14/47 , C07K14/435 , A61K38/00
摘要: A polypeptide obtainable by inducement under hypoxic conditions having a sequence comprising:(a) the amino acid sequence of SEQ ID NO:1 or 3 or a fragment thereof; (b) an amino acid sequence encoded by the nucleotide sequence of SEQ ID NO: 2 or 4 or a fragment thereof; or (c) an amino acid sequence resulting from deletion, addition, insertion or substitution of one or more amino acids in the amino acid sequence of SEQ ID NO:1 or 3; a polynucleotide encoding the above polypeptide or the fragment thereof useful for producing the above polypeptide by a biotechnological technique; and an antibody or fragment thereof specifically binding the above polypeptide.
摘要翻译: 通过在缺氧条件下诱导获得的多肽,其具有包含以下序列的序列:(a)SEQ ID NO:1或3的氨基酸序列或其片段; (b)由SEQ ID NO:2或4的核苷酸序列或其片段编码的氨基酸序列; 或(c)由SEQ ID NO:1或3的氨基酸序列中的一个或多个氨基酸的缺失,添加,插入或取代产生的氨基酸序列; 编码上述多肽或其片段的多核苷酸可用于通过生物技术生产上述多肽; 以及特异性结合上述多肽的抗体或其片段。
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