专利检索 ap:("Jun Jian Huang" OR "Cui-Fen Huang" OR "Marie C. M. Lin" OR "Hsiang-Fu Kung") AND inv:"Marie C. M. Lin" 第 1 页

1.

发明授权
Telomerase reverse transcriptase fragments and uses thereof 有权
标题翻译：端粒酶逆转录酶片段及其用途

公开(公告)号：US07294708B2

公开(公告)日：2007-11-13

申请号：US10449565

申请日：2003-05-30

申请人： Jun Jian Huang , Cui-Fen Huang , Marie C. M. Lin , Hsiang-Fu Kung

发明人： Jun Jian Huang , Cui-Fen Huang , Marie C. M. Lin , Hsiang-Fu Kung

IPC分类号： C07H21/02 , C12N5/00 , C12P21/06

CPC分类号： C12Y207/07049 , A61K38/00 , C07K2319/00 , C12N9/1276

摘要： The invention provides compositions comprising fragments of human telomerase reverse transcriptase (hTERT) which can lead to telomere dysfunction in a cell and reduction of growth and tumorigenicity in cancer cells. The invention also relates to uses of the fragments in the treatment of cancer and in drug discovery.

摘要翻译： 本发明提供包含人端粒酶逆转录酶（hTERT）片段的组合物，其可导致细胞中的端粒功能障碍，并降低癌细胞的生长和致瘤性。本发明还涉及片段在治疗癌症和药物发现中的用途。