公开(公告)号：US4731375A

公开(公告)日：1988-03-15

申请号：US806917

申请日：1985-12-09

申请人： Jun Nakano ,  Toshikazu Awaji ,  Kiyoshi Kuriyama ,  Yoshiyuki Hiyama ,  Toshiaki Okuda

发明人： Jun Nakano ,  Toshikazu Awaji ,  Kiyoshi Kuriyama ,  Yoshiyuki Hiyama ,  Toshiaki Okuda

IPC分类号： A61K31/41 ,  A61P37/08 ,  C07D405/04 ,  C07D257/04

CPC分类号： C07D405/04

摘要： A chromene derivative having the general formula (I): ##STR1## wherein n is 1 to 5 and --O--CH.sub.2).sub.n CO.sub.2 H group is attached to 5-position, 6-position, 7-position or 8-position, or salts thereof, a process for preparing the same and antiallergic agents containing the same.The compounds of the present invention inhibit the immunological release of chemical mediators such as SRS-A and histamine from mast cell and have an excellent effect in preventing and treating the various allergic diseases such as allergic asthma, allergic dermatitis, allergic nasitis, hives, allergic enteritis and allergic conjunctivitis, especially allergic asthma.

摘要翻译： 具有通式（I）的色烯衍生物：其中n为1至5，且-O-CH 2）n CO 2 H基团连接到5-位，6-位，7-位或8-位， 或其盐，其制备方法和含有它们的抗过敏剂。 本发明的化合物抑制了来自肥大细胞的化学介质如SRS-A和组胺的免疫释放，并且对预防和治疗各种过敏性疾病如过敏性哮喘，过敏性皮炎，过敏性鼻炎，荨麻疹，过敏性物质 肠炎和过敏性结膜炎，特别是过敏性哮喘。