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    Process for producing laurolactam
    3.
    发明授权
    Process for producing laurolactam 有权
    生产月桂内酰胺的方法

    公开(公告)号：US08309714B2

    公开(公告)日：2012-11-13

    申请号：US12744675

    申请日：2008-11-19

    申请人： Junichi Kugimoto ,  Joji Kawai ,  Hideo Shimomura ,  Ryouta Yasumatsu ,  Nobuhiro Ii

    发明人： Junichi Kugimoto ,  Joji Kawai ,  Hideo Shimomura ,  Ryouta Yasumatsu ,  Nobuhiro Ii

    IPC分类号： C07D201/04 ,  C07D225/02

    CPC分类号： C07D201/04 ,  C07D225/02 ,  Y02P20/582

    摘要： Provided is a process for efficiently producing laurolactam by simple steps from cyclododecanone and hydroxylamine. This production process comprises the steps of: (a) reacting cyclododecanone with hydroxylamine in an aqueous solution in the presence of an oxime-formation solvent to produce cyclododecanone oxime; (b) separating the reaction mixture obtained after the oxime-forming step into an oil and an aqueous phases and collecting a solution of cyclododecanone oxime of the oil phase; (c) removing a part or all of the oxime-formation solvent and dissolved water from the solution of cyclododecanone oxime which is collected as an oil phase in the oil/aqueous phase separation step, whereby preparing a solution containing a rearrangement solvent to be used in a rearrangement reaction in a later step and the cyclododecanone oxime; (d) producing laurolactam from cyclododecanone oxime by rearrangement reaction using an aromatic-ring containing compound as a rearrangement catalyst; and (e) separating and removing the rearrangement solvent and the rearrangement catalyst from the reaction mixture after the rearrangement step, and purifying the laurolactam.

    摘要翻译： 提供一种通过简单的步骤从环十二酮和羟胺有效地生产十二内酰胺的方法。 该制备方法包括以下步骤：（a）在肟形成溶剂存在下，使环十二酮与羟胺在水溶液中反应，生成环十二烷酮肟; （b）将在肟形成步骤后获得的反应混合物分离成油相和水相，并收集油相的环十二烷酮肟溶液; （c）从油/水相分离步骤中以油相收集的环十二烷酮肟溶液中除去部分或全部肟形成溶剂和溶解的水，由此制备含有使用的重排溶剂的溶液 在后续步骤中的重排反应和环十二酮肟; （d）使用含芳环的化合物作为重排催化剂，通过重排反应从环十二酮肟生产月桂内酰胺; 和（e）在重排步骤之后从反应混合物中分离和除去重排溶剂和重排催化剂，并纯化月桂内酰胺。

    PROCESS FOR PRODUCING LAUROLACTAM
    4.
    发明申请
    PROCESS FOR PRODUCING LAUROLACTAM 有权
    生产乳酸菌的方法

    公开(公告)号：US20100267944A1

    公开(公告)日：2010-10-21

    申请号：US12744675

    申请日：2008-11-19

    申请人： Junichi Kugimoto ,  Joji Kawai ,  Hideo Shimomura ,  Ryouta Yasumatsu ,  Nobuhiro II

    发明人： Junichi Kugimoto ,  Joji Kawai ,  Hideo Shimomura ,  Ryouta Yasumatsu ,  Nobuhiro II

    IPC分类号： C07D225/02

    CPC分类号： C07D201/04 ,  C07D225/02 ,  Y02P20/582

    摘要： Provided is a process for efficiently producing laurolactam by simple steps from cyclododecanone and hydroxylamine. This production process comprises the steps of: (a) reacting cyclododecanone with hydroxylamine in an aqueous solution in the presence of an oxime-formation solvent to produce cyclododecanone oxime; (b) separating the reaction mixture obtained after the oxime-forming step into an oil and an aqueous phases and collecting a solution of cyclododecanone oxime of the oil phase; (c) removing a part or all of the oxime-formation solvent and dissolved water from the solution of cyclododecanone oxime which is collected as an oil phase in the oil/aqueous phase separation step, whereby preparing a solution containing a rearrangement solvent to be used in a rearrangement reaction in a later step and the cyclododecanone oxime; (d) producing laurolactam from cyclododecanone oxime by rearrangement reaction using an aromatic-ring containing compound as a rearrangement catalyst; and (e) separating and removing the rearrangement solvent and the rearrangement catalyst from the reaction mixture after the rearrangement step, and purifying the laurolactam.

    摘要翻译： 提供一种通过简单的步骤从环十二酮和羟胺有效地生产十二内酰胺的方法。 该制备方法包括以下步骤：（a）在肟形成溶剂存在下，使环十二酮与羟胺在水溶液中反应，生成环十二酮肟; （b）将在肟形成步骤后获得的反应混合物分离成油相和水相，并收集油相的环十二烷酮肟溶液; （c）从油/水相分离步骤中以油相收集的环十二酮肟溶液中除去部分或全部肟形成溶剂和溶解的水，由此制备含有使用的重排溶剂的溶液 在后续步骤中的重排反应和环十二酮肟; （d）使用含芳环的化合物作为重排催化剂，通过重排反应从环十二酮肟生产月桂内酰胺; 和（e）在重排步骤之后从反应混合物中分离和除去重排溶剂和重排催化剂，并纯化月桂内酰胺。