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1.发明授权Methods of treating rheumatoid arthritis by multiple administration of anti-TNF antibodies 失效通过多次施用抗TNF抗体治疗类风湿性关节炎的方法公开(公告)号：US07179466B2
公开(公告)日：2007-02-20
申请号：US10187121
申请日：2002-06-28
申请人： Junming Le , Jan Vilcek , Peter Daddona , John Ghraveb , David Knight , Scott Siegel
发明人： Junming Le , Jan Vilcek , Peter Daddona , John Ghraveb , David Knight , Scott Siegel
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： A61K39/3955 , A61K31/167 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/485 , A61K31/519 , A61K31/573 , A61K38/00 , A61K45/00 , A61K45/06 , A61K2039/505 , C07K14/525 , C07K16/241 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C07K2319/00 , A61K2300/00
摘要： Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.
摘要翻译： 抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症的体内诊断和治疗，以及编码鼠和嵌合体的多核苷酸 提供了免疫测定和免疫治疗方法中的抗体，抗体的制备方法，抗TNF抗体的使用方法或其片段，区域或衍生物。
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公开(公告)号：US07179893B2
公开(公告)日：2007-02-20
申请号：US11400787
申请日：2006-04-07
申请人： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
发明人： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
CPC分类号： A61K39/3955 , A61K31/167 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/485 , A61K31/519 , A61K31/573 , A61K38/00 , A61K45/00 , A61K45/06 , A61K2039/505 , C07K14/525 , C07K16/241 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C07K2319/00 , A61K2300/00
摘要： Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.
摘要翻译： 抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症的体内诊断和治疗，以及编码鼠和嵌合体的多核苷酸 提供了免疫测定和免疫治疗方法中的抗体，抗体的制备方法，抗TNF抗体的使用方法或其片段，区域或衍生物。
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公开(公告)号：US07169388B2
公开(公告)日：2007-01-30
申请号：US10957134
申请日：2004-09-30
申请人： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
发明人： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/241 , A61K31/167 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/485 , A61K31/573 , A61K38/00 , A61K39/3955 , A61K2039/505 , C07K14/525 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/76 , C07K2319/00 , A61K2300/00
摘要： Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.
摘要翻译： 抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症的体内诊断和治疗，以及编码鼠和嵌合体的多核苷酸 提供了免疫测定和免疫治疗方法中的抗体，抗体的制备方法，抗TNF抗体的使用方法或其片段，区域或衍生物。
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公开(公告)号：US07166284B2
公开(公告)日：2007-01-23
申请号：US10371443
申请日：2003-02-21
申请人： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
发明人： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： A61K39/3955 , A61K31/167 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/485 , A61K31/519 , A61K31/573 , A61K38/00 , A61K45/00 , A61K45/06 , A61K2039/505 , C07K14/525 , C07K16/241 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C07K2319/00 , A61K2300/00
摘要： Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.
摘要翻译： 抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症的体内诊断和治疗，以及编码鼠和嵌合体的多核苷酸 提供了免疫测定和免疫治疗方法中的抗体，抗体的制备方法，抗TNF抗体的使用方法或其片段，区域或衍生物。
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5.发明申请METHODS OF TREATING INFLAMMATION ASSOCIATED WITH VIRAL INFECTION WITH ANTI-TNF ANTIBODIES 失效用抗TNF抗体治疗与病毒感染相关的炎症的方法公开(公告)号：US20070009524A1
公开(公告)日：2007-01-11
申请号：US10043436
申请日：2002-01-10
申请人： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
发明人： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
IPC分类号： A61K39/395 , C07H21/04
CPC分类号： C07K16/241 , A61K31/167 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/485 , A61K31/573 , A61K38/00 , A61K39/3955 , A61K2039/505 , C07K14/525 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/76 , C07K2319/00 , A61K2300/00
摘要： Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.
摘要翻译： 抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症的体内诊断和治疗，以及编码鼠和嵌合体的多核苷酸 提供了免疫测定和免疫治疗方法中的抗体，抗体的制备方法，抗TNF抗体的使用方法或其片段，区域或衍生物。
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公开(公告)号：US06991791B2
公开(公告)日：2006-01-31
申请号：US09766535
申请日：2001-01-18
申请人： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
发明人： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
IPC分类号： A61K39/395
CPC分类号： A61K39/3955 , A61K31/167 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/485 , A61K31/519 , A61K31/573 , A61K38/00 , A61K45/00 , A61K45/06 , A61K2039/505 , C07K14/525 , C07K16/241 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C07K2319/00 , A61K2300/00
摘要： Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.
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7.发明申请Methods of treating rheumatoid arthritis using anti-TNF receptor fusion proteins 审中-公开使用抗TNF受体融合蛋白治疗类风湿关节炎的方法公开(公告)号：US20050260201A1
公开(公告)日：2005-11-24
申请号：US11053749
申请日：2005-02-07
申请人： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel , Bernard Scallon
发明人： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel , Bernard Scallon
IPC分类号： A61K38/17 , A61K39/395 , C07K16/24
CPC分类号： C07K16/241 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/76
摘要： Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.
摘要翻译： 抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症的体内诊断和治疗，以及编码鼠和嵌合体的多核苷酸 提供了免疫测定和免疫治疗方法中的抗体，抗体的制备方法，抗TNF抗体的使用方法或其片段，区域或衍生物。
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公开(公告)号：US20080033149A1
公开(公告)日：2008-02-07
申请号：US11891036
申请日：2007-08-08
申请人： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
发明人： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
IPC分类号： C07K16/46
CPC分类号： A61K39/3955 , A61K31/167 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/485 , A61K31/519 , A61K31/573 , A61K38/00 , A61K45/00 , A61K45/06 , A61K2039/505 , C07K14/525 , C07K16/241 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C07K2319/00 , A61K2300/00
摘要： Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.
摘要翻译： 抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症的体内诊断和治疗，以及编码鼠和嵌合体的多核苷酸 提供了免疫测定和免疫治疗方法中的抗体，抗体的制备方法，抗TNF抗体的使用方法或其片段，区域或衍生物。
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9.发明申请公开(公告)号：US20070298040A1
公开(公告)日：2007-12-27
申请号：US11401391
申请日：2006-04-10
申请人： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
发明人： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
IPC分类号： A61K39/395
CPC分类号： C07K16/241 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/76 , Y02A50/412
摘要： Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFαx-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.
摘要翻译： 抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症的体内诊断和治疗，以及编码鼠和嵌合体的多核苷酸 提供了免疫测定和免疫治疗方法中的抗体，抗体的制备方法，抗TNF抗体的使用方法或其片段，区域或衍生物。
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公开(公告)号：US07276239B2
公开(公告)日：2007-10-02
申请号：US11314941
申请日：2005-12-20
申请人： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
发明人： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
IPC分类号： A61K39/395 , C07K16/24
CPC分类号： A61K39/3955 , A61K31/167 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/485 , A61K31/519 , A61K31/573 , A61K38/00 , A61K45/00 , A61K45/06 , A61K2039/505 , C07K14/525 , C07K16/241 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C07K2319/00 , A61K2300/00
摘要： Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.
摘要翻译： 抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症的体内诊断和治疗，以及编码鼠和嵌合体的多核苷酸 提供了免疫测定和免疫治疗方法中的抗体，抗体的制备方法，抗TNF抗体的使用方法或其片段，区域或衍生物。
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