公开(公告)号：US20240302349A1

公开(公告)日：2024-09-12

申请号：US18674099

申请日：2024-05-24

申请人： Juno Therapeutics, Inc.

发明人： Trevor DO ,  Howard STERN ,  Christina SWANSON

IPC分类号： G01N33/50 ,  A61K35/17 ,  C07K14/705

CPC分类号： G01N33/5017 ,  A61K35/17 ,  C07K14/705 ,  G01N33/5091 ,  G01N2333/70514 ,  G01N2800/52

摘要： Provided are methods and articles of manufacture for use with cell therapy for the treatment of diseases or conditions, e.g., cancer, including for predicting likelihood of the subject responding to a therapy, such as a cell therapy, e.g., a chimeric antigen receptor (CAR) T cell therapy. In some aspects, the predicting is based on detecting certain biomarkers of immune cells associated with and/or that correlate with response following administration of the therapy. The methods generally involve detecting a marker by assaying a biological sample from a subject that is a candidate for treatment, optionally with a cell therapy, to determine if the subject is likely to respond to the therapy. The present disclosure also provides methods for treating a subject having a disease or condition, in some cases involving administration of the cell therapy, based on assessment the biomarker. Also provided herein are reagents and kits for performing the methods.

公开(公告)号：US20210132042A1

公开(公告)日：2021-05-06

申请号：US16760381

申请日：2018-10-31

申请人： Juno Therapeutics, Inc.

发明人： Trevor DO ,  Howard STERN ,  Christina SWANSON

IPC分类号： G01N33/50 ,  C07K14/705 ,  A61K35/17

摘要： Provided are methods and articles of manufacture for use with cell therapy for the treatment of diseases or conditions, e.g., cancer, including for predicting likelihood of the subject responding to a therapy, such as a cell therapy, e.g., a chimeric antigen receptor (CAR) T cell therapy. In some aspects, the predicting is based on detecting certain biomarkers of immune cells associated with and/or that correlate with response following administration of the therapy. The methods generally involve detecting a marker by assaying a biological sample from a subject that is a candidate for treatment, optionally with a cell therapy, to determine if the subject is likely to respond to the therapy. The present disclosure also provides methods for treating a subject having a disease or condition, in some cases involving administration of the cell therapy, based on assessment the biomarker. Also provided herein are reagents and kits for performing the methods.