公开(公告)号：US3951618A

公开(公告)日：1976-04-20

申请号：US542477

申请日：1975-01-20

申请人： Jurg R. Pfister ,  Ian T. Harrison ,  John H. Fried

发明人： Jurg R. Pfister ,  Ian T. Harrison ,  John H. Fried

IPC分类号： C07D311/86 ,  A61K31/35

CPC分类号： C07D311/86

摘要： Compositions containing and methods employing, as the essential ingredient, novel disubstituted xanthone carboxylic acid compounds which are useful in the treatment of allergic conditions. Methods for preparing these compounds and compositions and intermediates therein are also disclosed. 5-Methylthio-7-isopropoxyxanthone-2-carboxylic acid and 5,7-di-(methylthio)xanthone-2-carboxylic acid are illustrated as representative compounds.

摘要翻译： 含有可用于治疗过敏症状的新型二取代呫吨酮羧酸化合物作为必需成分的组合物和方法。 还公开了制备这些化合物及其组合物和中间体的方法。 5-甲硫基-7-异丙氧基呫吨酮-2-羧酸和5,7-二（甲硫基）呫吨酮-2-羧酸作为代表性化合物。

公开(公告)号：US3979414A

公开(公告)日：1976-09-07

申请号：US637558

申请日：1975-12-04

申请人： Jurg R. Pfister ,  Ian T. Harrison ,  John H. Fried

发明人： Jurg R. Pfister ,  Ian T. Harrison ,  John H. Fried

IPC分类号： C07D311/86

CPC分类号： Y10S514/826

摘要： Compositions containing and methods employing, as the essential ingredient, novel disubstituted xanthone carboxylic acid compounds which are useful in the treatment of allergic conditions. Methods for preparing these compounds and compositions and intermediates therein are also disclosed. 5-Isopropyl-7-acetylxanthone-2-carboxylic acid is illustrated as a representative compound.

摘要翻译： 含有可用于治疗过敏症状的新型二取代呫吨酮羧酸化合物作为必需成分的组合物和方法。 还公开了制备这些化合物及其组合物和中间体的方法。 5-异丙基-7-乙酰呫吨酮-2-羧酸被示为代表性化合物。

公开(公告)号：US3989721A

公开(公告)日：1976-11-02

申请号：US637560

申请日：1975-12-04

申请人： Jurg R. Pfister ,  Ian T. Harrison ,  John H. Fried

发明人： Jurg R. Pfister ,  Ian T. Harrison ,  John H. Fried

IPC分类号： C07D311/86

CPC分类号： Y10S514/826

摘要： Compositions containing and methods employing, as the essential ingredient, novel disubstituted xanthone carboxylic acid compounds which are useful in the treatment of allergic conditions. Methods for preparing these compounds and compositions and intermediates therein are also disclosed. 5-Methylsulfinyl-7-isopropoxyxanthone-2-carboxylic acid and 5,7-di(methylsulfinyl)xanthone-2-carboxylic acid are illustrated as representative compounds.

公开(公告)号：US3963753A

公开(公告)日：1976-06-15

申请号：US558023

申请日：1975-03-13

申请人： Jurg R. Pfister ,  Ian T. Harrison ,  John H. Fried

发明人： Jurg R. Pfister ,  Ian T. Harrison ,  John H. Fried

IPC分类号： C07D311/86

摘要： Compositions containing and methods employing, as the essential ingredient, novel disubstituted xanthone carboxylic acid compounds which are useful in the treatment of allergic conditions. Methods for preparing these compounds and compositions and intermediates therein are also disclosed. 5-Methyl-sulfinyl-7-isopropoxyxanthone-2-carboxylic acid and 5,7-di(methylsulfinyl)xanthone-2-carboxylic acid are illustrated as representative compounds.

摘要翻译： 含有可用于治疗过敏症状的新型二取代呫吨酮羧酸化合物作为必需成分的组合物和方法。 还公开了制备这些化合物及其组合物和中间体的方法。 5-甲基亚磺酰基-7-异丙氧基呫吨酮-2-羧酸和5,7-二（甲基亚磺酰基）呫吨酮-2-羧酸作为代表性化合物。

公开(公告)号：US3949084A

公开(公告)日：1976-04-06

申请号：US543390

申请日：1975-01-23

申请人： Jurg R. Pfister ,  Ian T. Harrison ,  John H. Fried

发明人： Jurg R. Pfister ,  Ian T. Harrison ,  John H. Fried

IPC分类号： C07C65/24 ,  C07D311/86 ,  A61K31/35

CPC分类号： C07C65/24 ,  C07D311/86

摘要： Compositions containing and methods employing, as the essential ingredient, novel substituted xanthone carboxylic acid compounds which are useful in the treatment of allergic conditions. Methods for preparing these compounds and compositions and intermediates therein are also disclosed. 6-Acetylxanthone-2-carboxylic acid is illustrated as a representative compound.

摘要翻译： 含有可用于治疗过敏症状的新型取代的呫吨酮羧酸化合物作为必需成分的组合物和方法。 还公开了制备这些化合物及其组合物和中间体的方法。 6-乙酰呫吨酮-2-羧酸被示为代表性化合物。

公开(公告)号：US3989720A

公开(公告)日：1976-11-02

申请号：US637559

申请日：1975-12-04

申请人： Jurg R. Pfister ,  Ian T. Harrison ,  John H. Fried

发明人： Jurg R. Pfister ,  Ian T. Harrison ,  John H. Fried

IPC分类号： C07D311/86

CPC分类号： Y10S514/826

摘要： Compositions containing and methods employing, as the essential ingredient, novel disubstituted xanthone carboxylic acid compounds which are useful in the treatment of allergic conditions. Methods for preparing these compounds and compositions and intermediates therein are also disclosed. 5-Methylsulfinyl-7-isopropoxyxanthone-2-carboxylic acid and 5,7-di(methylsulfinyl)xanthone-2-carboxylic acid are illustrated as representative compounds.

公开(公告)号：US3988352A

公开(公告)日：1976-10-26

申请号：US637561

申请日：1975-12-04

申请人： Jurg R. Pfister ,  Ian T. Harrison ,  John H. Fried

发明人： Jurg R. Pfister ,  Ian T. Harrison ,  John H. Fried

IPC分类号： C07D311/86

摘要： Compositions containing and methods employing, as the essential ingredient, novel disubstituted xanthone carboxylic acid compounds which are useful in the treatment of allergic conditions. Methods for preparing these compounds and compositions and intermediates therein are also disclosed. 5-Methylsulfinyl-7-isopropoxyxanthone-2-carboxylic acid and 5,7-di(methylsulfinyl)xanthone-2-carboxylic acid are illustrated as representative compounds.

公开(公告)号：US3965115A

公开(公告)日：1976-06-22

申请号：US558025

申请日：1975-03-13

申请人： Jurg R. Pfister ,  Ian T. Harrison ,  John H. Fried

发明人： Jurg R. Pfister ,  Ian T. Harrison ,  John H. Fried

IPC分类号： C07D311/86

摘要： Compositions containing and methods employing, as the essential ingredient, novel disubstituted xanthone carboxylic acid compounds which are useful in the treatment of allergic conditions. Methods for preparing these compounds and compositions and intermediates therein are also disclosed. 5-Methyl-sulfinyl-7-isopropoxyxanthone-2-carboxylic acid and 5,7-di(methylsulfinyl)xanthone-2-carboxylic acid are illustrated as representative compounds.

公开(公告)号：US3963752A

公开(公告)日：1976-06-15

申请号：US558024

申请日：1975-03-13

申请人： Jurg R. Pfister ,  Ian T. Harrison ,  John H. Fried

发明人： Jurg R. Pfister ,  Ian T. Harrison ,  John H. Fried

IPC分类号： C07D311/86

摘要： Compositions containing and methods employing, as the essential ingredient, novel disubstituted xanthone carboxylic acid compounds which are useful in the treatment of allergic conditions. Methods for preparing these compounds and compositions and intermediates therein are also disclosed. 5-Methylsulfinyl-7-isopropoxyxanthone-2-carboxylic acid and 5,7-di(methylsulfinyl)xanthone-2-carboxylic acid are illustrated as representative compounds.

摘要翻译： 含有可用于治疗过敏症状的新型二取代呫吨酮羧酸化合物作为必需成分的组合物和方法。 还公开了制备这些化合物及其组合物和中间体的方法。 5-甲基亚磺酰基-7-异丙氧基呫吨酮-2-羧酸和5,7-二（甲基亚磺酰基）呫吨酮-2-羧酸作为代表性化合物。

公开(公告)号：US4207241A

公开(公告)日：1980-06-10

申请号：US890421

申请日：1978-03-27

申请人： John H. Fried ,  Ian T. Harrison

发明人： John H. Fried ,  Ian T. Harrison

IPC分类号： C07C1/22 ,  C07C1/24 ,  C07C45/28 ,  C07C45/46 ,  C07C49/697 ,  C07C49/755 ,  C07C51/367 ,  C07C51/373 ,  C07C63/34 ,  C07C233/12 ,  C07D307/20 ,  C07D309/06 ,  C07D309/12 ,  C07C63/595 ,  C07C69/76

CPC分类号： C07D309/12 ,  C07C1/22 ,  C07C1/24 ,  C07C323/00 ,  C07C45/28 ,  C07C45/46 ,  C07C51/367 ,  C07C51/373 ,  C07C63/34 ,  C07D307/20

摘要： 2-Naphthyl acetic acid derivatives and the corresponding amides, esters, hydroxamic acids and addition salts thereof, optionally substituted at the .alpha.-position on the acetic acid moiety and/or at position 6 and/or at positions 1, 4, 7 or 8 on the naphthyl ring and optionally saturated at positions 3 and 4, are anti-inflammatory, analgesic, antipyretic and anti-pruritic agents. A pharmaceutical method of effecting treatment of inflammation, pain, pyrexia and pruritus by the administration of naphthyl acetic acid derivatives. A pharmaceutical composition for use in the treatment of the above maladies comprising a naphthyl acetic acid derivative.

摘要翻译： 2-萘基乙酸衍生物和相应的酰胺，酯，异羟肟酸及其加成盐，任选在乙酸部分和/或第6位和/或第1,4,7或8位的α-位上被取代 在萘环上并且任选地在3和4位饱和是抗炎，止痛，解热和抗瘙痒剂。 通过给予萘基乙酸衍生物来治疗炎症，疼痛，发热和瘙痒的药物方法。 一种用于治疗上述疾病的药物组合物，其包含萘基乙酸衍生物。