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公开(公告)号：US20220409696A1
公开(公告)日：2022-12-29
申请号：US17837920
申请日：2022-06-10
发明人： Hanadie Yousef , Jeremy O'Connell , Thach Mai , Zhihua Li
摘要： Described herein are polypeptides comprising an IGF2 amino acid sequence and an amino acid sequence from a heterologous polypeptide useful for the treatment of soft-tissue and muscle diseases, disorders, and injuries. Mutations within the IGF2 amino acid sequence improved the stability of the molecule by reducing backbone cleavage. Also described herein are synergistic combinations of an Insulin-like Growth Factor 1 Receptor (IGF1R) agonist and a short chain fatty acid. Also described are methods of treating muscle and soft-tissue diseases comprising administering the polypeptides and/or synergistic compositions.
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公开(公告)号：US20230405089A1
公开(公告)日：2023-12-21
申请号：US18163155
申请日：2023-02-01
发明人： Hanadie Yousef , Jeremy O'Connell , Thach Mai , Rami Jaafar
CPC分类号： A61K38/30 , A61K38/1858 , A61P21/06 , A61K38/1875 , A61K38/1841 , A61K47/643 , A61K38/1825 , A61K47/6811
摘要： Described herein are therapeutic compositions comprising heparin-associated polypeptides useful for the treatment of soft-tissue and muscle diseases, disorders, and injuries.
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公开(公告)号：US20230312663A1
公开(公告)日：2023-10-05
申请号：US18163210
申请日：2023-02-01
发明人： Hanadie Yousef , Jeremy O'Connell , Thach Mai , Rami Jaafar , Zhihua Li
摘要： Described herein are polypeptides comprising an FGF17, IGF2, or BMP7 amino acid sequence and an amino acid sequence from a heterologous polypeptide useful for the treatment of soft-tissue and muscle diseases, disorders, and injuries. Also described herein are synergistic combinations of a Fibroblast Growth Factor Receptor agonist and a glycosaminoglycan, an Insulin-like Growth Factor 1 Receptor (IGF1R) agonist and a short chain fatty acid, and BMP receptor agonists and mTOR activators and/or glycosaminoglycans. Also described are methods of treating muscle and soft-tissue diseases comprising administering the polypeptides and/or synergistic compositions.
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公开(公告)号：US10821155B2
公开(公告)日：2020-11-03
申请号：US16455445
申请日：2019-06-27
发明人： Hanadie Yousef , Thach Mai , Jeremy O'Connell
摘要： Described herein are therapeutic compositions comprising heparin-associated polypeptides useful for the treatment of soft-tissue and muscle diseases, disorders, and injuries.
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公开(公告)号：US20240189397A1
公开(公告)日：2024-06-13
申请号：US17843676
申请日：2020-12-22
发明人： Hanadie Yousef , Jeremy O'Connell , Thach Mai , Rami Jaafar
CPC分类号： A61K38/30 , A61K38/1825 , A61K38/1841 , A61K38/1858 , A61K38/1875 , A61K47/643 , A61K47/6811 , A61P21/06
摘要： Described herein are therapeutic compositions comprising heparin-associated polypeptides useful for the treatment of soft-tissue and muscle diseases, disorders, and injuries.
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公开(公告)号：US20240024423A1
公开(公告)日：2024-01-25
申请号：US18448054
申请日：2023-08-10
发明人： Hanadie Yousef , Jeremy O'Connell , Thach Mai
CPC分类号： A61K38/2086 , A61K9/0019 , A61P21/00 , A61K38/30 , A61K38/1709 , A61K38/1825 , A61K38/39
摘要： Described herein are therapeutic compositions comprising heparin-associated polypeptides useful for the treatment of soft-tissue and muscle diseases, disorders, and injuries.
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公开(公告)号：US20230398187A1
公开(公告)日：2023-12-14
申请号：US17843748
申请日：2020-12-22
发明人： Hanadie Yousef , Jeremy O'Connell , Thach Mai , Rami Jaafar , Zhihua Li
摘要： Described herein are polypeptides comprising an FGF17, IGF2, or BMP? amino acid sequence and an amino acid sequence from a heterologous polypeptide useful for the treatment of soft-tissue and muscle diseases, disorders, and injuries. Also described herein are synergistic combinations of a Fibroblast Growth Factor Receptor agonist and a glycosaminoglycan, an Insulin-like Growth Factor 1 Receptor (IGF1R) agonist and a short chain fatty acid, and BMP receptor agonists and mTOR activators and/or glycosaminoglycans. Also described are methods of treating muscle and soft-tissue diseases comprising administering the polypeptides and/or synergistic compositions.
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公开(公告)号：US20210038693A1
公开(公告)日：2021-02-11
申请号：US17072636
申请日：2020-10-16
发明人： Hanadie Yousef , Jeremy O'Connell , Thach Mai
摘要： Described herein are therapeutic compositions comprising heparin-associated polypeptides useful for the treatment of soft-tissue and muscle diseases, disorders, and injuries.
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