公开(公告)号：US20240189397A1

公开(公告)日：2024-06-13

申请号：US17843676

申请日：2020-12-22

申请人： Juvena Therapeutics, Inc.

发明人： Hanadie Yousef ,  Jeremy O'Connell ,  Thach Mai ,  Rami Jaafar

IPC分类号： A61K38/30 ,  A61K38/18 ,  A61K47/64 ,  A61K47/68 ,  A61P21/06

CPC分类号： A61K38/30 ,  A61K38/1825 ,  A61K38/1841 ,  A61K38/1858 ,  A61K38/1875 ,  A61K47/643 ,  A61K47/6811 ,  A61P21/06

摘要： Described herein are therapeutic compositions comprising heparin-associated polypeptides useful for the treatment of soft-tissue and muscle diseases, disorders, and injuries.

公开(公告)号：US11964000B2

公开(公告)日：2024-04-23

申请号：US17227943

申请日：2021-04-12

申请人： Northwestern University

发明人： Samuel I. Stupp ,  Mark Trosper McClendon ,  Guifa Xi ,  Bo Timmy Bjoern Fyrner ,  Cara S. Smith ,  Nicholas A. Sather

IPC分类号： A61K38/18 ,  A61K45/06 ,  A61K47/54 ,  A61K47/61 ,  A61K47/64 ,  A61P35/00

CPC分类号： A61K38/1875 ,  A61K45/06 ,  A61K47/549 ,  A61K47/61 ,  A61K47/641 ,  A61K47/645 ,  A61P35/00

摘要： Provided herein are compositions comprising peptide amphiphiles, glycosylated peptide amphiphiles (GPAs), supramolecular nanostructures assembled therefrom, and methods of use thereof. The peptide amphiphiles described herein may extend the half-life of bone morphogenic proteins, promote cell differentiation, suppress proliferation, and increase chemosensitivity of cells. Accordingly, the compositions described herein may be used for cancer treatment methods. In particular, provided herein are bone morphogenic proteins bound to peptide amphiphiles and glycosylated peptide amphiphiles or composites thereof, and methods of use of the same for the treatment of cancer. Also, provided herein are bone morphogenic proteins bound to peptide amphiphiles and glycosylated peptide amphiphiles or composites thereof, and methods of use of the same in a combinatorial approach together with chemotherapeutic medications for the treatment of cancer.

公开(公告)号：US20240018187A1

公开(公告)日：2024-01-18

申请号：US18451003

申请日：2023-08-16

申请人： THERADAPTIVE, INC.

发明人： Luis ALVAREZ

IPC分类号： C07K7/08 ,  C07K14/00 ,  A61P19/00 ,  C07K14/51 ,  C07K14/475 ,  A61K38/18 ,  A61K38/04 ,  A61K38/16

CPC分类号： C07K7/08 ,  C07K14/001 ,  A61P19/00 ,  C07K14/51 ,  C07K14/475 ,  A61K38/1875 ,  A61K38/04 ,  A61K38/16

摘要： Provided herein are polypeptides that include one or more β-tricalcium phosphate (βTCP)-binding sequence(s) and uses thereof.

公开(公告)号：US11872264B2

公开(公告)日：2024-01-16

申请号：US17498615

申请日：2021-10-11

申请人： Chondropeptix B.V.

发明人： Tim Johannes Maria Welting ,  Marjolein Maria Johanna Caron

IPC分类号： A61K38/18 ,  A61K38/16 ,  A61K38/10 ,  A61P19/02

CPC分类号： A61K38/1875 ,  A61K38/10 ,  A61K38/16 ,  A61P19/02

摘要： The present invention is in the field of medicine and provides means and methods for the treatment, prevention or amelioration of osteoarthritis. More in particular, it provides a peptide for use in the treatment, amelioration or prevention of osteoarthritis, wherein the peptide is between 12 and 28 amino acids in length and comprises an amino acid sequence according to SEQ ID NO: 16 or a variant thereof according to formula 2, wherein the amino acid sequence of said peptide is comprised in SEQ ID NO: 34 or a variant thereof according to formula 1.

公开(公告)号：US11844802B2

公开(公告)日：2023-12-19

申请号：US17936184

申请日：2022-09-28

申请人： Emory University ,  The United States Government as represented by the Department of Veterans Affairs

发明人： Scott D. Boden ,  Sreedhara Sangadala

IPC分类号： A61K31/53 ,  A61L27/54 ,  C07D251/18 ,  A61K38/18

CPC分类号： A61K31/53 ,  A61K38/1875 ,  A61L27/54 ,  C07D251/18 ,  A61L2300/412 ,  A61L2430/02 ,  A61K31/53 ,  A61K2300/00

摘要： The disclosure relates to compounds and compositions for forming bone and methods related thereto. In one embodiment, the disclosure relates to a composition comprising a compound disclosed herein, such as 2,4-diamino-1,3,5-triazine derivatives or salts thereof, for use in bone growth processes. In a typical embodiment, a bone graft composition is implanted in a subject at a site of desired bone growth or enhancement.

公开(公告)号：US20230330147A1

公开(公告)日：2023-10-19

申请号：US18043095

申请日：2021-08-31

申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

发明人： Jae-Won SHIN ,  Sing Wan Wong ,  Zhangli PENG

IPC分类号： A61K35/28 ,  C12N5/0775 ,  A61P21/00 ,  A61K38/18 ,  A61K47/36 ,  A61P11/00 ,  A61K38/19 ,  A61K9/06 ,  C12N5/00

CPC分类号： A61K35/28 ,  C12N5/0663 ,  A61P21/00 ,  A61K38/1875 ,  A61K47/36 ,  A61P11/00 ,  A61K38/191 ,  A61K9/06 ,  C12N5/0012 ,  C12N2537/10 ,  C12N2533/74

摘要： This invention provides a cross-linked alginate hydrogel layer encapsulating single mesenchymal stromal cells or progenitor cells, as well as compositions including the encapsulated cells and to methods of using the same to promote osteogenesis and fibrotic tissue repair in a subject.

公开(公告)号：US20190247542A1

公开(公告)日：2019-08-15

申请号：US16274047

申请日：2019-02-12

申请人： University of Southampton

发明人： Richard Oreffo ,  Jonathan Dawson ,  David Gibbs ,  Jons Hilborn ,  Dmitri Ossipov

IPC分类号： A61L27/44 ,  A61L27/54 ,  A61K47/02 ,  C08K3/34 ,  A61K38/18 ,  C08J3/075 ,  A61L27/52

CPC分类号： A61L27/446 ,  A61K38/1875 ,  A61K47/02 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/414 ,  A61L2300/64 ,  A61L2400/12 ,  A61L2430/02 ,  C08J3/075 ,  C08J2305/08 ,  C08K3/346 ,  C08K2201/006 ,  C08L5/08

摘要： The invention relates to a polymer-clay composite material comprising clay nanoparticles and a polymer, and wherein (a) the polymer comprises phosphate and/or phosphonate ligands; or (b) the polymer-clay composite further comprises linker molecules comprising a phosphate or phosphonate ligand, wherein the linker molecules are arranged to be anchored to the polymer. The invention further relates to organoclays, BMP-clay composite material. Uses, treatments, and manufacturer of the material are also provided.

公开(公告)号：US20180237746A1

公开(公告)日：2018-08-23

申请号：US15847009

申请日：2017-12-19

申请人： Stan Gronthos ,  Andrew Christopher William Zannettino

发明人： Stan Gronthos ,  Andrew Christopher William Zannettino

IPC分类号： C12N5/0735 ,  A61K38/18 ,  A61L27/38 ,  A61K38/19 ,  C12N5/0775 ,  A61K35/28 ,  A61K38/20

CPC分类号： C12N5/0606 ,  A61K35/28 ,  A61K38/1858 ,  A61K38/1875 ,  A61K38/191 ,  A61K38/195 ,  A61K38/2006 ,  A61L27/3804 ,  A61L27/3839 ,  A61L27/3886 ,  A61L27/3895 ,  C12N5/0662 ,  C12N5/0663 ,  C12N5/0664 ,  C12N5/0665 ,  C12N5/0666 ,  C12N5/0667 ,  C12N5/0668 ,  C12N2510/00 ,  A61K2300/00

摘要： The invention relates to multipotential expanded mesenchymal precursor progeny (MEMP's), characterised by the early developmental markers STRO-1bri and ALP. The present invention also relates to methods for producing MEMP's and to uses of MEMP's for therapeutic applications.

公开(公告)号：US10047155B2

公开(公告)日：2018-08-14

申请号：US15165150

申请日：2016-05-26

申请人： NOVARTIS AG

发明人： Zijun Chen ,  Sujun Deng ,  Yun He ,  Dagang Huang ,  Markus Kugler ,  Qian Li ,  Chris Xiangyang Lu ,  Xiao Luo ,  Yongqiang Shan ,  Kathrin Ulrike Tissot-Daguette ,  Jing Wu

IPC分类号： C07K16/22 ,  A61K39/395 ,  A61K38/18 ,  C12N15/13 ,  C12N15/63 ,  C12N15/09 ,  A61K45/06 ,  A61K31/155 ,  A61K31/355 ,  A61K31/4439 ,  A61K31/4725 ,  A61K31/497 ,  A61K31/513 ,  A61K31/522 ,  A61K31/575 ,  A61K31/675 ,  A61K31/7072 ,  A61K39/00

CPC分类号： C07K16/22 ,  A61K31/155 ,  A61K31/355 ,  A61K31/4439 ,  A61K31/4725 ,  A61K31/497 ,  A61K31/513 ,  A61K31/522 ,  A61K31/575 ,  A61K31/675 ,  A61K31/7072 ,  A61K38/1875 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/90 ,  C07K2317/92 ,  C07K2317/94 ,  C12N15/09 ,  C12N15/63 ,  A61K2300/00

摘要： The present invention relates to isolated antibodies and antigen-binding fragments thereof which bind human BMP9 and compositions and methods of use thereof.

公开(公告)号：US20180221413A1

公开(公告)日：2018-08-09

申请号：US15928509

申请日：2018-03-22

申请人： ARTHRODYNAMIC HOLDINGS, LLC

发明人： Frank D. Marcum

IPC分类号： A61K35/28 ,  A61K31/728

CPC分类号： A61K35/28 ,  A61B17/06166 ,  A61B17/064 ,  A61B2017/00004 ,  A61K31/715 ,  A61K31/728 ,  A61K35/35 ,  A61K38/18 ,  A61K38/1825 ,  A61K38/1841 ,  A61K38/1875 ,  A61K38/27 ,  A61K38/30 ,  A61K45/06 ,  A61L27/26 ,  A61L27/34 ,  A61L27/3834 ,  A61L27/3852 ,  A61L27/54 ,  A61L2300/41 ,  A61L2300/414 ,  A61L2300/426 ,  A61L2300/43 ,  A61L2400/06 ,  C08L5/08 ,  A61K2300/00

摘要： A pharmaceutical preparation and method for treating connective tissue damage in a mammal comprising administering to a mammal in need thereof a therapeutically effective amount of a glycosaminoglycan composition comprising chondroitin sulfate, hyaluronan, and N-acetyl D-glucosamine, wherein the connective tissue is skin.