公开(公告)号：US20240408154A1

公开(公告)日：2024-12-12

申请号：US18705636

申请日：2022-10-28

Applicant: KABUSHIKI KAISHA YAKULT HONSHA

Inventor： Ayaka MAKI ,  Tomoaki NAITO ,  Saya TAJIMA ,  Tetsuji HORI ,  Satoshi MATSUMOTO

IPC: A61K35/744 ,  A23L33/135 ,  A61P37/04 ,  C12N1/20

Abstract: Provided is an enhancer of number of TCR clones containing live lactic acid bacteria as an active ingredient. Provided is an enhancer of number of TCR clones, containing live lactic acid bacteria as an active ingredient, wherein after vaccination with CD4 carrying TRBV19 such as vaccination with IEV or a virus carrying an epitope recognized by CD8 positive T cells, the number of TCR clones carrying TRBV19 is enhanced.