公开(公告)号：US20210238637A1

公开(公告)日：2021-08-05

申请号：US17049756

申请日：2019-04-25

Applicant: KANEKA CORPORATION

Inventor： Yasuyuki SUZUKI ,  Fumitaka KAMO ,  Chanon KHUHAPREMA ,  Akihisa KANDA

IPC: C12P7/66 ,  B01D71/02 ,  B01D67/00 ,  B01D37/02

Abstract: Stable and economical methods for producing coenzyme Q10A are described. These methods include concentrating a culture suspension of a coenzyme Q10-producing microorganism efficiently, while minimizing a loss of coenzyme Q10 prior to an extraction step or a homogenization process. The methods for producing coenzyme Q10 may comprise a filtration step of passing a culture suspension of a coenzyme Q10-producing microorganism through a porous membrane in a state where the culture suspension is heated to a heating temperature of 35° C. or higher. In order to improve the average permeation flux, a regenerating step may be performed, preferably at least once, which involves closing a filtration device, applying pressure, and then releasing the pressure; or a regeneration treatment of allowing a medium to flow in from a filtrate outlet side and passing the medium through the porous membrane for a certain time, prior to normal filtration.

公开(公告)号：US20220266210A1

公开(公告)日：2022-08-25

申请号：US17742035

申请日：2022-05-11

Applicant: KANEKA CORPORATION

Inventor： Takafumi IGARI ,  Shihomi NISHIMORI ,  Masaru HIRANO ,  Hiroaki ICHIRIKI ,  Akihisa KANDA

IPC: B01J2/06 ,  C12N1/20

Abstract: A method for producing lipid particles, including: injecting molten lipids directly into a liquid at a temperature lower than a melting point of the lipids through a liquid supply port of a two-fluid nozzle while injecting a gas directly into the liquid through a gas supply port of the two-fluid nozzle, so that the molten lipids are dispersed and atomized into particles in the liquid due to the gas and the particles are solidified to form lipid particles. The lipids have a water solubility of 10 g/L or less at 25° C. and are solid at 25° C. The two-fluid nozzle is heated to a temperature at least 10° C. higher than the melting point of the lipids. A ratio D50/Nd of a volume median diameter D50 of the lipid particles to an orifice diameter Nd of the liquid supply port of the two-fluid nozzle is 0.0017 or more and 0.17 or less.